Notes in X. Wilm's Tumor

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Published	12/09/2024	Wilms Tumor aka {{c1::Nephroblastoma}}
Published	12/09/2024	Approximately 5-10% of Wilms tumors involve {{c1::both kidneys}}, either simultaneously, synchronously, or one after the other
Published	12/09/2024	Children typically present with a large abdominal mass, which may be {{c1::unilateral}} ▪ When very large
Published	12/09/2024	Other common symptoms of Wilms Tumor include: ▪ {{c1::Hematuria (blood in urine)}} ▪ {{c2::Abdominal pain}}, which can follow a traumatic incident ▪ {…
Published	12/09/2024	In a significant number of cases, {{c1::pulmonary metastasis}} may be present at the time of the primary diagnosis
Published	12/09/2024	Most patients can expect to be cured of their malignancy, especially if the tumor is {{c1::removed surgically}}
Published	12/09/2024	Most critical determinant of adverse prognosis of Wilms Tumor is {{c1::Anaplastic histology}}
Published	12/09/2024	Three (3) recognizable groups of congenital malformations1. WAGR syndrome2. Denys-Drash syndrome3. {{c1::Beckwith-Wiedmann syndrome}}
Published	12/09/2024	Groups of congenital malformation in Wilm's Tumor that is characterized with macroglossia, organomegaly etc is {{c1::Beckwith-Wiedmann syndrome}}
Published	12/09/2024	Risk of Wilms tumor is increased with at least {{c1::3}} recognizable groups of congenital malformations associated with distinct chromosomal loci
Published	12/09/2024	WAGR → W - Wilms Tumor → A - {{c1::Aniridia}} → G - {{c2::Genitourinary}} → R - Retardation or intellectual disability
Published	12/09/2024	Wilms Tumor:Carry institutional germline deletion of chromosome {{c1::11}}
Published	12/09/2024	Most of the time Wilms tumor is {{c1::sporadic}}
Published	12/09/2024	Gross Anatomy of Wilms Tumor → Wilms tumor tend to present as a {{c1::large solitary well-circumscribed}} mass
Published	12/09/2024	Wilm's TumorThe presence of anaplasia correlates with the presence of {{c1::pp53}} mutations and the emergence of resistance to chemotherapy
Published	12/09/2024	Wilms Tumor occasionally have {{c1::nephrogenic rests}}, these are putative precursor regions of Wilms Tumor and are seen in the renal parenchyma adja…
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