Notes in 05. Drug Clearance Through Metabolism

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Status	Last Update	Fields
Published	10/21/2024	Estimates the volume of blood from which the drug is cleared per unit of time → {{c1::Clearance (CL)}}
Published	10/21/2024	The composite estimate reflecting all mechanisms of drug elimination → {{c1::Total Clearance}}
Published	10/21/2024	Three Major Routes of Elimination{{c1::Hepatic Elimination}}{{c1::Biliary Elimination}}{{c1::Urinary Elimination}}
Published	10/21/2024	CYP3A4/5 is responsible for the metabolism of approximately {{c1::36%}} of drugs metabolized by cytochrome P450 enzymes
Published	10/21/2024	CYP2D6 is responsible for the metabolism of approximately {{c1::19%}} of drugs metabolized by cytochrome P450 enzymes
Published	10/21/2024	CYP2C8/9 is responsible for the metabolism of approximately {{c1::16%}} of drugs metabolized by cytochrome P450 enzymes
Published	10/21/2024	YP1A2 is responsible for the metabolism of approximately {{c1::11%}} of drugs metabolized by cytochrome P450 enzymes
Published	10/21/2024	CYP2C19 is responsible for the metabolism of approximately {{c1::8%}} of drugs metabolized by cytochrome P450 enzymes
Published	10/21/2024	CYP2E1 is responsible for the metabolism of approximately {{c1::4%}} of drugs metabolized by cytochrome P450 enzymes
Published	10/21/2024	CYP2A6 and CYP2B6 each are responsible for the metabolism of approximately {{c1::3%}} of drugs metabolized by cytochrome P450 enzymes
Published	10/21/2024	The phase of drug metabolism, where drugs undergo {{c1::oxidation, reduction, and/or hydrolysis}} to become more polar, is known as {{c2::phase I}}
Published	10/21/2024	In phase I metabolism, the drug may be {{c1::activated, remain unchanged or most often, be inactivated}}
Published	10/21/2024	Drugs that are lipophilic begin in {{c1::phase I}} of drug metabolism
Published	10/21/2024	Following phase I, drugs may directly enter phase II metabolism: TRUE OR FALSE{{c1:: TRUE}}
Published	10/21/2024	The products of phase II metabolism are primarily conjugation products that are usually {{c1::inactive}} and {{c1::more water soluble}}
Published	10/21/2024	The {{c1::half-life}} of a drug is defined as the time it takes for one-half of the drug to be eliminated by the body
Published	10/21/2024	Understanding the half-life of a drug helps clinicians determine the {{c1::amount of drug}} and the {{c1::timing of administration}}
Published	10/21/2024	Factors that affect the half-life of a drug include the {{c1::rate of absorption}}, {{c1::metabolism}}, and {{c1::excretion}}
Status	Last Update	Fields