Notes in L6 - Synthesis of Heme

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Published	11/02/2024	Heme is a {{c1::porphyrin}}
Published	11/02/2024	{{c1::Heme}} is the final product of the porphyrin synthetic pathway, and is the most important porphyrin in humans
Published	11/02/2024	Heme is a porphyrin that consists of one {{c1::Fe2+ atom}} in the center of {{c1::protoporphyrin IX}}
Published	11/02/2024	Major sites of heme biosynthesis are the {{c1::liver}} and {{c1::erythrocyte-producing cells of the bone marrow}}
Published	11/02/2024	The heme biosynthesis pathway begins and ends in {{c1::mitochondria}}, while the steps in between occur in the {{c1::cytosol}}
Published	11/02/2024	Step 1 of Heme Biosynthesis:
Published	11/02/2024	In Step 1 of Heme biosynthesis, formation of ALA by ALA Synthase requires {{c1::pyridoxal phosphate}} as a coenzyme
Published	11/02/2024	Step 2 of Heme Biosynthesis:
Published	11/02/2024	Step 3 of Heme Biosynthesis:
Published	11/02/2024	{{c1::Heme}} and {{c1::Hemin}} can inhibit formation of ALA
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