Notes in 11.1 Neisseriaceae

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Published	07/30/2024	Representative Neisseriaceae pathogens are{{c1::A::Ana/A}}erobicGram ({{c2::-}}){{c3::Non-m::Non-m/M}}otile
Published	07/30/2024	Representative Neisseriaceae species Slide Morphology: {{c1::Kidney-shaped w/ flattened ends strung together inside polymorphonuclear cells (intr…
Published	07/30/2024	[QC] Capsule1. Neisseria gonorrhoeae2. Neisseria meningitidis{{c1::B}}
Published	07/30/2024	[QC] Capsule1. Neisseria gonorrhoeae2. Neisseria meningitidis{{c1::A}}
Published	07/30/2024	[QC] Can grow in anaerobic conditions1. Neisseria gonorrhoeae2. Neisseria meningitidis{{c1::A}}
Published	07/30/2024	Neisseriaceae Biochemical tests:Oxidase ({{c1::+}})Catalse ({{c1::+}})There is an exception: {{c1::Neisseria elongata is catalase (-)}}
Published	07/30/2024	Neisseria gonorrhoeae Media: {{c1::Enriched chocolate blood agar, Thayer-Martin (MTM) agar, NYC medium, Martin-Lewis media}}
Published	07/30/2024	[QC] Fastidious1. Neisseria gonorrhoeae2. Neisseria meningitidis{{c1::A}}
Published	07/30/2024	[QC] Capnophilicity1. Neisseria gonorrhoeae2. Neisseria meningitidis{{c1::A}}
Published	07/30/2024	Neisseria Colony Morphology: {{c1::Convex, Mucoid, Transparent-Opaque Non-hemolytic white colonies, 1-5 mm}}
Published	07/30/2024	The part of Neisseria pili that contains high percentage of hydrophobic amino acids that are conserved is the {{c1::amino terminal}}
Published	07/30/2024	The part of Neisseria pili that serves as attachment to host cells and is conserved is the is the {{c1::amino acid sequence near the midportion}}
Published	07/30/2024	The part of Neisseria pili that is most prominent in the immune response because of its variability is the {{c1::carboxy terminal}}
Published	07/30/2024	{{c1::Por}} is a virulence factor of Neisseria that extends through the gonococcal cell membrane and prevents phagosome-lysosome fusion and occur…
Published	07/30/2024	Variable resistance of gonococci to killing by normal human serum depends on whether it {{c1::selectively binds to complement components (C3b and C4b)…
Published	07/30/2024	{{c1::Opa (Opacity) Protein}} is a virulence factor of Neisseria that allows adhesion of gonococci within colonies and attachment to the followin…
Published	07/30/2024	{{c1::Reduction modifiable Protein (Rmp, Protein III)}} is a virulence factor of Neisseria gonorrhoeae that is antigenically conserved in al…
Published	07/30/2024	{{c1::Lipooligosaccharide (LOS)}} is a virulence factor of Neisseria gonorrhoeae that is like LPS but WITHOUT the long O antigen side chains
Published	07/30/2024	Toxicity in gonococcal infections is largely attributable to the endotoxic effects of {{c1::LOS}}
Published	07/30/2024	{{c1::Fbp (Ferric binding protein)}} is a virulence factor of Neisseria gonorrhoeae that is expressed when available iron supply is limited,…
Published	07/30/2024	{{c1::IgA1 protease}} is a virulence factor of Neisseria gonorrhoeae that splits and inactivates IgA1, a major mucosal immunoglobulin
Published	07/30/2024	{{c1::Tumor Endothelial Migration (TEM-1)}} is a plasmid of Neisseria gonorrhoeae that terminates the mitotic spindle
Published	07/30/2024	{{c1::Streptococcal gene tetM}} is a gene of Neisseria gonorrhoeae that can be inserted and offers {{c2::tetracycline::antibiotic}} resistan…
Published	07/30/2024	Think of Neisseriaceae infection in px w/ {{c1::complement deficiencies::disorder}}
Published	07/30/2024	Only {{c1::piliated}} Neisseria gonorrhoeae appear to be virulent
Published	07/30/2024	Gonococci that form {{c1::opaque::transparent/opaque}} colonies are isolated from men w/ {{c2::symptomatic urethritis}}women w/ {{c2::uterine cervical…
Published	07/30/2024	Gonococci that form {{c1::transparent::transparent/opaque}} colonies are isolated from men w/ {{c2::asymptomatic urethritis}}women w/ {{c2::menstruati…
Published	07/30/2024	Neisseria gonorrhoeae Male Infection Clinical Findings:Acute: {{c1::Urethritis w/ yellow creamy pus & dysuria}}Chronic: Fibrosis → {{c1::Uret…
Published	07/30/2024	Neisseria gonorrhoeae Male Infection can reach the {{c1::epididymis::male reproductive tract area}}
Published	07/30/2024	Neisseria gonorrhoeae Female Infection Clinical Findings:Acute: Mucopurulent discharge of the {{c1::endocervix::primary infected area}}, then ure…
Published	07/30/2024	Neisseria gonorrhoeae Newborn Infection Clinical Findings:{{c1::Gonococcal ophthalmia neonatorum}}
Published	07/30/2024	Gonococcal ophthalmia neonatorum DOC: {{c1::0.5% erythromycin or 1% tetracycline ointment}}
Published	07/30/2024	Neisseria gonorrhoeae Male Infection Diagnosis:{{c1::Urethral exudate w/ Gram-negative diplococci within PMNs (intracellular diplococci)Symptomat…
Published	07/30/2024	Neisseria gonorrhoeae Female Infection Diagnosis:{{c1::Endocervical exudate w/ Gram-negative diplococci within PMNs (intracellular diplococci)AND…
Published	07/30/2024	Neisseria gonorrhoeae can oxidize {{c1::glucose::carbohydrate}}
Published	07/30/2024	Neisseria gonorrhoeae Gold Standard Diagnostic Test: {{c1::Nucleic Acid Amplification Test (NAAT)}}
Published	07/30/2024	Neisseria gonorrhoeae Test-Of-Cure: {{c1::Recollect specimens and microscopy}}
Published	07/30/2024	Immunity against Neisseria gonorrhoeae develops after {{c1::never::Time frame}}
Published	07/30/2024	Neisseria gonorrhoeae DOC: {{c1::Ceftriaxone, Azithromycin}}
Published	07/30/2024	Aside from Ceftrixone and Azithromycin, what other ancillary treatments do you give in px with Neisseria gonorrhoeae?{{c1::Doxycycline for possible co…
Published	07/30/2024	Most important capsules for Neisseria meningitidis have polysaccharide subgroups associated with {{c1::A,B,C,X,Y and W-135}}
Published	07/30/2024	[QC] LPS1. Neisseria gonorrhoeae2. Neisseria meningitidis{{c1::B}}
Published	07/30/2024	Neisseria meningitidis MOT: {{c1::Inhalation to Nasopharynx, Direct contact w/ respiratory secretions}}
Published	07/30/2024	Neisseria meningitidis Risk Factors:{{c1::Lack of bactericidal antibody (IgM/IgG)Presence of blocking IgA antibody (in mucosal surfaces)Complemen…
Published	07/30/2024	Neisseria meningitidis 3 Most Common Symptomatic Diseases:{{c1::Acute MeningitisFulminant MeningococcemiaWaterhouse-Friderichsen Syndrome (WFS)::…
Published	07/30/2024	{{c1::Acute Meningitis}} is the most common complication of meningococcal bacteremia
Published	07/30/2024	Neisseria meningitidis {{c2::Acute Meningitis::Disease}} Clinical Findings:{{c1::Intense headache, vomiting, photophobia, confusion, and stiff ne…
Published	07/30/2024	Neisseria meningitidis {{c2::Fulminant Meningitis::Disease}} Clinical Findings:{{c1::Severe↑ feverCapillary leak syndromeThrombosis → petichial h…
Published	07/30/2024	Neisseria meningitidis {{c2::Waterhouse-Friderichsen Syndrome::Disease}} Clinical Findings:{{c1::DICCirculatory collapseBIlateral hemorrhagic nec…
Published	07/30/2024	Neisseria meningitidis Diagnosis:{{c1::Gram-stain of sediment of centrifuge of Blood (petechial aspirate) or Spinal Fluid w/ Neisseria}}
Published	07/30/2024	Neisseria meningitidis Media: {{c1::Sheep blood agar or Chocolate agar for CSFModified Thayer Martin for nasopharyngeal cultures}}
Published	07/30/2024	Neisseria meningitidis can oxidize {{c1::glucose, maltose::carbohydrate}}
Published	07/30/2024	Neisseria meningitidis DOC: {{c1::Penicillin G}}
Published	07/30/2024	Neisseria meningitidis w/ penicillin allergy DOC: {{c1::Chloramphenicol, 3rd generation Cephalosporins: Cefotaxime, Ceftriaxone}}
Published	07/30/2024	Neisseria meningitidis Vaccinations:Serogroup ({{c1::A, C, W, Y}}) meningococcal conjugate for px {{c2::11-12 y/o w/ booster at 16 y/o and >65…
Published	07/30/2024	Neisseria meningitidis Chemoprophylaxis: {{c1::Rifampin, Ciprofloxacin, Ceftriaxone}}
Published	07/30/2024	Moraxella catarrhalis Slide Morphology: {{c1::gram (-), diplococci}}
Published	07/30/2024	Moraxella catarrhalis is oxidase ({{c1::+}})
Published	07/30/2024	Moraxella catarrhalis Diagnosis: {{c1::Rapid Fluorometric tests}}
Published	07/30/2024	Moraxella catarrhalis Infection Clinical Findings:{{c1::BronchitisPneumoniaSinusitisOtitis mediaConjunctivitis::5}}
Published	07/30/2024	Moraxella catarrhalis Rapid fluorometric tests look for {{c1::butyrate esterase}}
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