Notes in L2 - Regulation & Inhibition of Enzymes

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Published	11/02/2024	The enzyme active site acts as a flexible molecular template that binds the substrate and stabilizes it in the {{c1::transition state}}
Published	11/02/2024	What factors affect the reaction velocity of an enzyme-catalyzed reaction?
Published	11/02/2024	What is the Michaelis-Menten equation?
Published	11/02/2024	Km reflects the {{c1::affinity of enzyme for substrate}}
Published	11/02/2024	Km is equal to {{c1::substrate concentration when reaction velocity = Vmax/2}}
Published	11/02/2024	What does a large v.s. a small Km indicate?
Published	11/02/2024	Lineweaver-Burke Plot and equation
Published	11/02/2024	What effect does a competitive inhibitor have on Vmax and Km?
Published	11/02/2024	What's a clinical example of a competitive inhibitor?
Published	11/02/2024	How are Vmax and Km affected by noncompetitive inhibition?
Published	11/02/2024	Most drugs that are enzyme inhibitors are probably {{c1::competitive}} inhibitors
Published	11/02/2024	Rates of most enzymes are responsive to changes in substrate concentration because {{c1::the intracellular level of many substrates is in the range of…
Published	11/02/2024	Allosteric enzymes are regulated by substances called {{c1::effectors (or modifiers)}} that bind noncovalently at a site other than the active site.&n…
Published	11/02/2024	What can the presence of an allosteric effector alter?
Published	11/02/2024	{{c1::Competitive Inhibition}} – the inhibitor binds to the same site on the enzyme that substrate normally binds; therefore, the inhibitor binds…
Published	11/02/2024	{{c1::Noncompetitive Inhibition}} - inhibitor and substrate bind to different sites on the enzyme
Published	11/02/2024	{{c1::Lead poisoning}} is an example of noncompetitive inhibition
Published	11/02/2024	{{c1::Homotropic}} effectors - the substrate itself serves as the effector
Published	11/02/2024	{{c1::Heterotropic}} effectors - the effector is a different molecule than the substrate.
Published	11/02/2024	Many enzymes are regulated by covalent modification, most frequently by the addition or removal of {{c1::phosphate}} groups from specific {{c1::serine…
Published	11/02/2024	Enzyme activity can be regulated through {{c1::allosteric effectors}}, {{c1::covalent modfication}}, or {{c1::induction and repression of enzyme synth…
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