Notes in LE019 Pharmacogenomics

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Published	10/07/2024	{{c1::Aminoglycoside}} antibiotics attack human {{c2::mitochondrial 12S rRNA}} with A1555G mutation
Published	10/07/2024	childhood acute lymphoblastic leukemia (ALL) is treated with {{c1::6-mercaptopurine (6-MP)}}. 1 in 300 has fatal reaction, 1 in 30 adverse reaction du…
Published	10/07/2024	Gene-Drug interactions mediated through metabolism: {{c1::G6PD}} deficiency --> {{c2::hemolytic anemia}} in response to {{c7::primaquine, phen…
Published	10/12/2024	{{c1::Stevens Johnson syndrome}}affects 2:10,000 who take carbamazepinealso associated with anticonvulsants, antipsychotics, anti-gout, sulfonamide an…
Published	10/07/2024	Warfarin (anticoagulant) dosing dependent on genetic makeup/any variants of key genes:{{c1::CYP2C9}} inactivates Warfarin {{c2::VKORC1}} is essen…
Published	10/07/2024	Drugs that have been shelved due to a lack of efficacy in greater population may be highly effective in a subset of patients dependent on their {{c1::…
Published	10/07/2024	Rational drug therapy based on genetic targets has been most widely used in antagonizing activated {{c1::oncogenic}} pathways in {{c2::cancer.}}
Published	10/07/2024	Implementing pharmacogenetics for drug choice and drug dosage in acutely ill patients would best be accomplished by {{c1::systematic pharmacogenetic}}…
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