Notes in PKPD::Pharmacodynamics

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Status	Last Update	Fields
Published	10/03/2024	Define affinity
Published	10/03/2024	Define constants for ligand binding
Published	10/03/2024	Define the equilibrium dissociation constant Kd
Published	10/03/2024	Define potency
Published	10/03/2024	Define efficacy
Published	10/03/2024	The following describes which class of receptor drug:  A ligand that binds to a receptor and alters the receptor state resulting in a biologic…
Published	10/03/2024	The following describes which class of receptor drug:  A drug that reduces the action of an agonist (e.g. a neurotransmitter, hormone, or a dr…
Published	10/03/2024	The following describes which class of receptor drug: A ligand that increases or decreases the action of an (primary or orthosteric) agonist …
Published	10/03/2024	Name the following units of the rate constants:{{c1::𝑘𝑜𝑓𝑓}} has the units of {{c2::1/time}}{{c1::𝑘𝑜𝑛}} has the units of {{c2::1/(time x conc…
Published	10/03/2024	Equilibrium is shifted towards the inactive state when adding a ligand. This must be a ligand with an alpha value of {{c1::a<1}}, therefore an {{c1…
Published	10/03/2024	Equilibrium is shifted towards the active state when adding a ligand. This must be a ligand with an alpha value of {{c1::a>1}}, therefore an {{c1::…
Published	10/03/2024	Equilibrium is not shifted when adding a ligand. This must be a ligand with an alpha value of {{c1::a=1}}, therefore an {{c1::inverse agonist inhibiti…
Published	10/03/2024	Define receptor occupancy (+formula)
Published	10/03/2024	Conformational selection as a mechanism in receptor theory If the receptor shows activity even in the absence of a ligand, this is known as (...)…
Published	10/03/2024	How would you describe LRa in the following model (multiple correct)
Published	10/03/2024	116a1b7f7b8241b0bc85fdc3fad99116-ao-1
Published	10/03/2024	116a1b7f7b8241b0bc85fdc3fad99116-ao-2
Published	10/03/2024	116a1b7f7b8241b0bc85fdc3fad99116-ao-3
Published	10/03/2024	116a1b7f7b8241b0bc85fdc3fad99116-ao-4
Published	10/03/2024	Differentiate b/w competitve and non-competitive binding
Published	10/03/2024	The (...) value is a common measurement in competitive inhibition. It’s the concentration of the inhibitor that reduces the biological response b…
Published	10/03/2024	Determine these three key measurments by their description(...): This is the maximum level of inhibition a drug can produce.(...): The concentration o…
Published	10/03/2024	Which of the following would be good measures of a drug's affinity?
Published	10/03/2024	Which of the following would be good measures of a drug's potency?
Published	10/03/2024	Which of the following would be good measures of a drug's efficacy?
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