Notes in Li L06 Tablets

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Published	10/11/2023	Tablet Dosage Forms (Slide 2)USP Definition“Tablets are solid dosage forms in which the {{c1::drug substance is generally blended with excipients…
Published	10/11/2023	Tablets (Slide 3)Tablets are based on {{c1::intended usage}} (4)Tablets delivered into {{c1::GI tract}}Tablets used in {{c1::oral cavity}}Su…
Published	10/11/2023	Tablets Delivered into GI Tract (per oral) (Slide 4)Tablets for {{c1::Systemic}} and {{c1::Local}} Effects{{c1::Sugar-Coated Tablets}} (SCT){{c1:…
Published	10/11/2023	Tablets for Use in the Oral Cavity (Slide 5)For Local and Systemic Effects{{c1::Sublingual}} tablet - Nitroglycerin{{c1::Buccal}} table…
Published	10/11/2023	Tablets to Prepare Solutions (Slide 6){{c1::Effervescent}} tabletFor taste masking, buffering etc.{{c1::Hypodermic}} tabletFor parenteral us…
Published	10/11/2023	Tablets for Miscallaneous Use (Sldie 7){{c1::Vaginal}} tabletFor local infections (ovoid shape){{c1::Implantable}} tablet{{c1::Diagnostic}}&…
Published	10/11/2023	Tablets: Advantages and Disadvantages (Slide 8)Advantages (6)Provide {{c1::accurate dosing}}Are {{c1::cheaper}} than other dosage formsEasy to {{c1::m…
Published	10/11/2023	Oral Administration of Tablets (Slide 9)Administration – Place it on the tongue and swallow with a glass of water or beverageIf administered without w…
Published	10/11/2023	Tablet Excipients (Slide 10)Pharmaceutic Ingredients for Tablet{{c1::DiluentsBinders and adhesivesMoisturizing/wetting agents}}{{c2::DisintegrantsLubr…
Published	10/11/2023	Diluents/Fillers/Bulking Agentsto {{c1::increase the bulk of individual tablet to a workable size}}{{c2::Cellulose derivativesLactose USPMannitol USP}…
Published	10/11/2023	Binders and Adhesives 9S;ode 13)to {{c1::promote the granulation process and/or cohesion}}{{c2::StarchAcaciaGelatin}}{{c3::Sodium alginateCellulose de…
Published	10/11/2023	Disintegrants (Slide 14)Purpose: {{c1::to facilitate tablet disintegration in the GI tract}}{{c1::StarchAlginatesPVP (cross-linked)CelluloseClays}} …
Published	10/11/2023	Disintegration Time {{c1::increases}} as the concentration of disintegrants {{c1::decreases}} (Slide 15)
Published	10/11/2023	Lubricants (Slide 16)Purpose: to {{c1::reduce the friction during the tablet compression and ejection}}{{c2::TalcStearic acid salts, Na and MgSurfacta…
Published	10/11/2023	Talc (Slide 17){{c1::very fine crystalline}} powderwhite or greyish white{{c2::hydrous magnesium silicate}} containing small amount of {{c2::aluminum …
Published	10/11/2023	Gildants (Slide 18)Purpose: to {{c1::promote the flow of the tablet granules or powder}}{{c1::Silica}} derivatives{{c1::colloidal silicon dioxide…
Published	10/11/2023	Antiadherents (Slide 19)Purpose: to {{c1::reduce sticking or adhesion of the tablet granules or powder to the punches and die walls}}{{c1::Magnesium s…
Published	10/11/2023	Coloring Agents (Slide 20)Purpose: to give an {{c1::elegant appearance and identificatons}} of the drug{{c1::Dyes}}FD&C D&CExternal D&amp…
Published	10/11/2023	Flavoring Agents (Slide 22)Purpose: to {{c1::improve the taste or acceptability}}{{c1::FlavorsSweeteners}}
Published	10/11/2023	Adsorbents (Slide 23)Purpose: to {{c1::hold the liquid}} and form an {{c1::apparently-dry powder}}{{c1::Magnesium OxideBentoniteSilicon Dioxide}}
Published	10/11/2023	Types of Tablets (Slide 24)Based on: the {{c1::method of manufacture}}{{c1::Compressed}} tablets{{c1::3D-printed}} tablets{{c1::Molded}}&nbs…
Published	10/11/2023	Compressed Tablets (Slide 25)These tablets are made by {{c1::applying pressure}} on {{c1::powders}} or {{c1::granules}} using {{c1::punches and dies.}…
Published	10/11/2023	Manufacture Methods (Slide 26)Compressed TabletsFine powders need {{c1::conversion to granules}} for {{c1::better flow}}{{c1::Wet}} granulation{{c1::D…
Published	10/11/2023	Steps in Tablet Manufacture (Slide 28){{c1::WeighingParticle size reductionBlending}}{{c2::Wetting & Dough formationExtrudingDrying}}{{c3::ScreenL…
Published	10/11/2023	Tablets Manufactured by 3D Printing Technology (Slide 36)Tablets are manufactured by {{c1::binding the powders}} using {{c1::adhesives}…
Published	10/11/2023	Spiritam - The First 3D-Printed Tablet ProductActive ingredient: {{c1::levetiracetam}}Indication: {{c1::epilepsy}}Dose: {{c1::250, 500, 750, 1000}} mg…
Published	10/11/2023	Molded Tablets (Slide 39)Tablets are prepared by {{c1::forcing the wet triturate}} into a {{c1::mold}} to form the {{c1::tabl…
Published	10/11/2023	Molded Tablets (Slide 40)As DilutentsLactosea-Lactose (brittle)b-Lactose  - preferred-dissolves fasterSucrose {{c1::used in combination with…
Published	10/11/2023	Coating of Tablets (Slide 41){{c1::Compression}} coating{{c1::Sugar}} coating{{c1::Chocolate}} coating/colored (iron oxides also){{c1::…
Published	10/11/2023	Enteric Coating (Slide 42)Enteric refers to the {{c1::small intestine.}}Prevent {{c1::irritation}}Protects drug- {{c1::pH of the stomac…
Published	10/11/2023	Enteric Coating Examples (Slide 43)ShellacMethacrylic acid copolymersHydroxypropyl methylcellulose PhthalateCellulose Acetate PhthalatePhthalic acid d…
Published	10/11/2023	Multiple-Compressed Tablets (Slide 45)Tablets made by {{c1::more than one compression cycle}}suitable for {{c1::incompatible drugs}}Contents are layer…
Published	10/11/2023	Evaluation of Tablets (Slide 52){{c1::Weight variationThicknessContent Uniformity}}{{c2::DisintegrationDissolutionStability}}{{c3::HardnessFriability}…
Published	10/11/2023	Evaluation of Tablets (Slide 53)Weight variation{{c1::Not less than 30 tablets should be tested}}HardnessProportional to {{c1::compaction pressur…
Published	10/11/2023	Disintengration (Slide 54)A {{c1::solid}} dosage form, i.e. tablet or capsule, {{c1::breaks down to smaller particles.}}
Published	10/11/2023	Noyes-Whitney Equation (Slide 56){{c1::dc/dt = kS(cs - ct)}}dc/dt = the {{c1::rate of dissolution}}k = the {{c1::dissolution rate constant}}S = t…
Published	10/11/2023	Noyes-Whitney Equation (Slide 56){{c1::dc/dt = kS(cs - ct)}}dc/dt = the {{c1::rate of dissolution}}k = the {{c1::dissolution rate constant}}S = t…
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