Notes in Inflammation and Complemen

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Published	01/10/2024	What mechanical barriers in innate immune defense?
Published	01/10/2024	What are the chemical barriers in innate immune defense?
Published	01/10/2024	What are the biological barriers in innate defense?
Published	01/10/2024	How is inflammation an innate defense mechanism?
Published	01/10/2024	What cellular responses are part of the innate immune defense?
Published	01/10/2024	{{c1::Complement}} is a system of {{c2::plasma proteins}} synthesized in {{c3::the liver}}
Published	01/10/2024	Complement proteins exist in the plasma and on cell surfaces as {{c1::inactive precursors (zymogens)}} that are activated at the {{c1::site of inflamm…
Published	01/10/2024	Complement proteins act as {{c1::proteases}} and cleave one another in the cascade
Published	01/10/2024	Complement activation leads to a cascade of reactions that occurs on {{c1::the surface of pathogens}} and generates active components with various eff…
Published	01/10/2024	Broadly, what purpose does the complement system serve?
Published	01/10/2024	{{c1::Opsonization}} of invading pathogens mediated by coating of pathogens by {{c2::C3b and IgG activation of phagocytosis}}
Published	01/10/2024	{{c1::Chemotaxis}} mediated by release of {{c2::C5a}} into bloodstream
Published	01/10/2024	{{c2::Direct cytolysis of pathogens}} through formation of the {{c1::membrane attack complex (MAC)}}
Published	01/10/2024	{{c1::C1q}} links the {{c2::adaptive humoral immune response}} to the {{c2::complement system}} by binding to antibodies complexed with …
Published	01/10/2024	How does the classical pathway of complement activation work?
Published	01/10/2024	{{c1::C3a and C5a}} serve as {{c2::chemokines}} that {{c3::recruit innate phagocytic cells to sites of inflammation }}
Published	01/10/2024	On binding of MBL to bacterial surfaces, {{c2::serine proteases}} become activated and can then activate the complement system by {{c1::cleaving a…
Published	01/10/2024	MBL binds with high avidity to {{c1::mannose and fucose residues}} on pathogen surface
Published	01/10/2024	{{c2::Ficolin}} binds surface resides on the pathogen specifically {{c1::acetylated sugars }}
Published	01/10/2024	C3b proteins bind to C3 convertase, and turn it into a C4b2b3b protein complex called {{c1::C5 convertase}}
Published	01/10/2024	How does the MB-Lectin pathway work?
Published	01/10/2024	How does the alternative pathway work?
Published	01/10/2024	Innate phagocytic cells that possess C3b receptors can {{c1::bind and engulf targets}} once attracted
Published	01/10/2024	How does the MAC complex form?
Published	01/10/2024	How does opsonization improve phagocytosis?
Published	01/10/2024	What are NETs and how do they work?
Published	01/10/2024	How does NK cell mediated ADCC work?
Published	01/10/2024	What are individuals who lack C5, C6, C7, or C8 at risk for?
Published	01/10/2024	What are individuals who lack C1, C2, C3, or C4 at risk for?
Published	01/10/2024	What is serous inflammation?
Published	01/10/2024	What characterizes purulent inflammation?
Published	01/10/2024	What is cellulitis?
Published	01/10/2024	What is the histological defintion of an ulcer?
Published	01/10/2024	Process of scar formation
Published	01/10/2024	What is lymphangitis?
Published	01/10/2024	What is granulomatous inflammation?
Published	01/10/2024	What genetic defects can cause chronic granulomatous disease?
Published	01/10/2024	What are we looking at?
Published	01/10/2024	What is seen in this image?
Published	01/10/2024	What are we looking at here?
Published	01/10/2024	What are we looking at here?
Published	01/10/2024	What are the three characterisitc findings of chronic inflammation?
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