Notes in i. Tyrosine Kinase Receptors

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Status	Last Update	Fields
Published	07/28/2024	Receptor kinases signal from?
Published	07/28/2024	What are the 3 ways intracellular signaling complexes can be activated?
Published	07/28/2024	ligands for {{c1::RTKs}} include {{c2::growth factors}}, {{c2::insulin}}, and {{c2::ephrins}} and are different to {{c1::TK-ARs}} whose ligands are {{…
Published	07/28/2024	The first step of RTK signaling following ligand binding is?
Published	07/28/2024	After RTKs dimerize, what is the next step?
Published	07/28/2024	After activation of intrinsic tyrosine kinase activity in RTKs, what is the next step?
Published	07/28/2024	After receptors are autophosphorylated in RTKs, what is the next step?
Published	07/28/2024	Proteins that bind receptor phosphotyrosine residues have an {{c1::SH2}} domain
Published	07/28/2024	b5aae24dc7ed498188967c3bdb003b43-ao-1
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Published	07/28/2024	b5aae24dc7ed498188967c3bdb003b43-ao-5
Published	07/28/2024	{{c1::Grb2}} is an SH2-domain protein that acts as an adaptor between activated RTKs and {{c2::SOS}} a GEF protein needed for activation of Ras
Published	07/28/2024	The small G-protein {{c1::Ras}} will activate the kinase {{c2::Raf}}
Published	07/28/2024	Ras activation initiates a cascade of {{c1::serine/threonine phosphorylation}} resulting in activation of {{c2::Mitogen Activated Protein (M…
Published	07/28/2024	Activation of MAP kinase is responsible for?
Published	07/28/2024	a1ac6f846db143d99ec31ee9900af3e1-ao-1
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Published	07/28/2024	a1ac6f846db143d99ec31ee9900af3e1-ao-4
Published	07/28/2024	Activation of {{c1::PI3-Kinase}} via {{c3::RTK}} generates {{c2::PI (3,4,5) triphosphate (PIP3)}} from PIP(4,5)P2 that acts a membrane docki…
Published	07/28/2024	bef62ee06dcd4e40a218a1f2f27b7d1d-ao-1
Published	07/28/2024	bef62ee06dcd4e40a218a1f2f27b7d1d-ao-2
Published	07/28/2024	bef62ee06dcd4e40a218a1f2f27b7d1d-ao-3
Published	07/28/2024	bef62ee06dcd4e40a218a1f2f27b7d1d-ao-4
Published	07/28/2024	bef62ee06dcd4e40a218a1f2f27b7d1d-ao-5
Published	07/28/2024	bef62ee06dcd4e40a218a1f2f27b7d1d-ao-6
Published	07/28/2024	Akt is activated following the binding to a {{c1::PIP3}} and being phosphorylated by {{c2::mTOR}} and {{c2::PDK1}} which causes dissoci…
Published	07/28/2024	Insulin binding is an example of RTK phosphorylation of {{c1::adaptor}} and {{c1::scaffolding}} proteins as part of {{c1::modular}} interaction domain…
Published	07/28/2024	A net effect of insulin binding a receptor tyrosine kinase (tyrosine signaling pathway) is to translocate {{c1::GLUT4}} from the cytoplasmic vesicles …
Published	07/28/2024	RTK {{c1::activity}} is required for internalization via clathrin coated pits and targeting to lysosomes
Published	07/28/2024	Tyrosine phosphatases {{c1::oppose}} the action of RTKs
Published	07/28/2024	Ligands for {{c1::TK-ARs}} include growth hormone and cytokines
Published	07/28/2024	Receptors for cytokines that participate in inflammatory responses and immune system function are {{c1::TK-ARs}}
Published	07/28/2024	Receptors for growth hormone, prolactin, and ECM proteins are {{c1::TK-ARs}}
Published	07/28/2024	Binding of a ligand to a TK-AR results in? (3 events)
Published	07/28/2024	629b4a5e55294a169f37b9737dd00d59-ao-1
Published	07/28/2024	629b4a5e55294a169f37b9737dd00d59-ao-2
Published	07/28/2024	629b4a5e55294a169f37b9737dd00d59-ao-3
Published	07/28/2024	In the JAK-STAT pathway, binding of {{c1::cytokines}} (interleukins & interferons), {{c1::growth}} hormone, {{c1::prolactin}}, and {{c1::extracell…
Published	07/28/2024	In the JAK-STAT pathway, activated {{c1::JAKs}} phosphorylate tyrosine residues on the {{c2::receptors}}
Published	07/28/2024	In the JAK-STAT pathway, {{c1::STATs}} dock on specific phosphotyrosines on the receptors, where the {{c2::JAKs}} phosphorylate them
Published	07/28/2024	In the JAK-STAT pathway, {{c1::STATs}} dissociate from receptors and dimerize via their {{c2::SH2}} domains
Published	07/28/2024	In the JAK-STAT pathway, {{c1::STATs}} translocate to the nucleus and act as transcription factors
Published	07/28/2024	{{c1::Integrins}} are {{c1::TK-ARs}} that serve as cell adhesion moleculues
Published	07/28/2024	Integrins associate with {{c1::FAK (focal adhesion kinase)}} a nonreceptor protein tyrosine kinase that is activated by binding to {{c2::ECM}}
Published	07/28/2024	Focal Adhesion Kinase (FAK)x activation results in binding of SH2 domain proteins, resulting in {{c1::Ras}} activation and {{c2::SRC}} activ…
Published	07/28/2024	15f23625f4284160b0f25b9243f1fc3d-ao-1
Published	07/28/2024	15f23625f4284160b0f25b9243f1fc3d-ao-2
Published	07/28/2024	15f23625f4284160b0f25b9243f1fc3d-ao-3
Published	07/28/2024	15f23625f4284160b0f25b9243f1fc3d-ao-4
Published	07/28/2024	15f23625f4284160b0f25b9243f1fc3d-ao-5
Published	07/28/2024	15f23625f4284160b0f25b9243f1fc3d-ao-6
Published	07/28/2024	15f23625f4284160b0f25b9243f1fc3d-ao-7
Published	07/28/2024	{{c1::Receptor Serine/Threonine kinases}} are a part of the {{c2::TGF-beta protein superfamily}}
Published	07/28/2024	{{c1::Receptor Serine/threonine kinases}} are a family of transmembrane proteins with intracellular domains with intrinsic {{c1::ser/thr kinase}} cata…
Published	07/28/2024	For receptor serine/threonine kinases, signal transduction follows ligand binding to {{c1::type II}} receptors that phosphorylate and activate&nb…
Published	07/28/2024	In Receptor serine/threonine kinases, the type I receptor phosphorylate and activate {{c1::SMADs}} that recruit protein complexes to DNA elements…
Published	07/28/2024	857a6253c4304de097071c6189a034f0-ao-1
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Published	07/28/2024	857a6253c4304de097071c6189a034f0-ao-4
Published	07/28/2024	Receptor kinases signal from the {{c1::cell-surface}} to the nucleus
Published	07/28/2024	The family of tyrosine kinases are categorized based on what? What are some of the subsections?
Published	07/28/2024	Achondroplasia is caused by mutations in {{c1::fibroblast growth-factor receptor 3 gene (FGFR-3)}} which causes {{c1::dominant-negative}} inhibition b…
Published	07/28/2024	Receptor kinases signal from the {{c1::cell-surface}} to the {{c1::nucleus}}
Published	07/28/2024	{{c1::Tocilizumab}} and {{c1::sarilumab}} and {{c1::humira}} are antibodies to cytokine ligands that play a role in TK-AR signaling pathways thus they…
Published	07/28/2024	Mutations in TK-AR signaling cause which diseases?
Published	07/28/2024	TGF-Beta family proteins are a family of transmembrane proteins with intracellular domains with intrinsic {{c1::Ser/Thr}} kinase activity and are acti…
Published	07/28/2024	Steps in down regulation of RTK signaling
Status	Last Update	Fields