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Published	11/05/2024	types of hemoglobin in normal adults
Published	11/05/2024	types of hemoglobin in fetus
Published	11/05/2024	adult hemoglobin replaces fetal hemoglobin {{c1::2-3 month}} (time) after birth
Published	11/05/2024	function of fetal Hb
Published	11/05/2024	there are {{c1::8}} alpha helices in {{c2::myoblobin (Mb)}} and {{c2::hemoglobin (Hb) beta subunit}}
Published	11/05/2024	there are {{c1::7}} alpha helices in {{c2::hemoglobin (Hb) alpha subunit}}
Published	11/05/2024	similarities between myoglobin and hemoglobin
Published	11/05/2024	heme group has a complex organic ring structure called {{c1::protoporphrin}} with an iron atom in the center
Published	11/05/2024	iron in the heme group is in the {{c1::ferrous (Fe2+)}} oxidation state
Published	11/05/2024	delete
Published	11/05/2024	the {{c1::fifth}} and {{c1::sixth}} coordination positions in the heme group are perpendicular to the porphyrin ring
Published	11/05/2024	the Fe2+ binds to the {{c1::tetrapyrrole ring (protoporphyrin IX complex)}} in the heme group
Published	11/05/2024	heme binds to globin proteins through proximal {{c1::His (F8 His 93)}} residue
Published	11/05/2024	oxygen binds to heme by a {{c1::non-covalent}} bond
Published	11/05/2024	oxygen bound to the heme group is stabilized through {{c2::hydrogen}} bonding with the {{c1::distal His (E7 His 64)}} residue
Published	11/05/2024	the heme group is present in a {{c1::hydrophobic}} (hydrophilic/hydrophobic) pocket in the globin protein
Published	11/05/2024	{{c1::oxygen}} binds to Hb changing it's electronic properties this accounts in color change of blood
Published	11/05/2024	the alpha gene cluster is on chromosome {{c1::16}}
Published	11/05/2024	the beta gene (globulin) family is on chromosome {{c1::11}}
Published	11/05/2024	when is the zeta globin gene expressed
Published	11/05/2024	when does epislon globin gene get expressed
Published	11/05/2024	there are 2 gamma genes (globin subunit) which are {{c1::G-gamma}} and {{c1::A-gamma}} expressed in {{c2::fetal}} hemoglobin
Published	11/05/2024	example of important hemeproteins (proteins with prosthetic heme group)
Published	11/05/2024	porphyrin is formed by linkage of four {{c1::pyrrole rings}} bound through {{c1::methenyl bridges}}
Published	11/05/2024	magnesium containing porphyrin is called {{c1::chlorophyll}}
Published	11/05/2024	sites of synthesis of heme (which organs)
Published	11/05/2024	delta Aminolevulinic acid is formed by {{c2::condensation}} reaction between {{c1::succinyl-CoA}} and {{c1::glycine}}
Published	11/05/2024	ALA synthesis is catalyzed by ALA synthase in the presence of {{c1::pyridoxal phosphate (A coenzyme of vitamin B6)}}
Published	11/05/2024	the rate limiting enzyme of heme synthesis
Published	11/05/2024	site of sythesis of ALA in the cell (heme synthesis)
Published	11/05/2024	site of formation of porphobilinogen (PBG) in the cell (heme sythesis)
Published	11/05/2024	porphobilongen (PBG) is formed by {{c2::condensation}} reaction between {{c1::two ALA molecules}}
Published	11/05/2024	enzyme used in formation of Porphobilinogen
Published	11/05/2024	cystolic ALA dehydratase contains {{c1::Zinc}} metal
Published	11/05/2024	products produced by cystolic ALA dehydratase
Published	11/05/2024	enzymes in heme sythesis inhibited by lead
Published	11/05/2024	site of ferrochelatase in the cell
Published	11/05/2024	Condensation of 4 PBG form the {{c1::first porphrinogens}}
Published	11/05/2024	generally what occurs to the first porphrinogens to form protoporphyrin IX
Published	11/05/2024	isoenzymes of ALA synthase and there sites in human body
Published	11/05/2024	complications caused by mutation (loss of function) of ALAS2
Published	11/05/2024	what occurs to excess heme in the body
Published	11/05/2024	how does hemin repress heme synthesis
Published	11/05/2024	ALAS2 regulation is controlled by {{c1::intercellular iron availability}}
Published	11/05/2024	drugs such as {{c1::barbiturates}} and {{c1::steroids}} increase activity of ALAS1 in the liver
Published	11/05/2024	compounds (not-drugs) such as {{c1::insecticides}} and {{c1::carcinogens}} increase activity of ALAS1 in the liver
Published	11/05/2024	mechanism resulting in increased heme synthesis in liver due to drugs and compounds?
Published	11/05/2024	how does hypoxia increase ALA synthase activity in the bone marrow
Published	11/05/2024	Lead poisining leads to {{c1::sideroblastic}} anemia
Published	11/05/2024	in porphyrias there is accumulation and increased excretion of {{c1::porphyrins or porphyrin percursors}}
Published	11/05/2024	clinical feataures of patients with porphyrias
Published	11/05/2024	{{c1::myoglobin}} (hemeprotein) has a hyperbolic O2 binding curve
Published	11/05/2024	{{c1::hemoglobin}} (hemeprotein) has a sigmoid O2 binding curve
Published	11/05/2024	PO50 of myoglobin
Published	11/05/2024	PO50 of hemoglobin
Published	11/05/2024	all reactions of heme synthesis are {{c1::irreversible}} (reversible/irreversible)
Status	Last Update	Fields