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Notes in
MtM VIII (Mitosis)
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Published
11/11/2024
There are 5 stages of mitosis: {{c1::prophase}}, {{c1::prometaphase}}, {{c1::metaphase}}, {{c1::anaphase}} and {{c1::telophase}}.
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In {{c3::Prophase}}, {{c1::duplicated chromosomes}} {{c2::condense}} and {{c1::mitotic spindle}} assembles between {{c2::centrosomes}}. {{c1::Centroso…
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In {{c3::prometaphase}}, the {{c1::nuclear envelope}} breaks down. Chromosomes attach to {{c1::mitotic spindles}} at their {{c2::kinetochores}} at cen…
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In {{c3::metaphase}}, chromosomes {{c1::align at the equator}}, with all the {{c1::kinetochores}} being attached to {{c2::spindles}} at both sides of …
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In {{c3::anaphase}}, {{c1::sister chromatids}} are {{c2::pulled apart}} and {{c1::kinetochore microtubules}} get {{c2::shorter}}.
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In {{c2::telophase}}, the two sets of chromosomes arrive at {{c1::opposite poles}} and the {{c1::nuclear envelope}} begins to reform.
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In {{c3::cytokenisis}}, a {{c1::contractile ring}} (made of {{c2::actin}} and {{c2::myosin}} filaments) {{c2::pinch}} the cell forming a {{c1::cleavag…
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In {{c3::G1 phase}}, the cell {{c1::grows}} and organelles {{c2::replicate}} and there is also a checkpoint which checks for {{c2::DNA errors}} b…
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In {{c2::S-phase}}, {{c1::DNA is replicated}}.
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In {{c1::G2-phase}}, there is a checkpoint to check for {{c2::replication errors}} before entry to {{c3::mitotic phase}} and the cell {{c2::continues …
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The {{c1::G1-Cdk}} complex drives the cell towards the {{c2::S phase}}.
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{{c1::S-Cdk complexes}} controls the entry of cell into {{c2::S-phase}}.
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{{c1::M-Cdk}} complexes controls entry into {{c2::Mitosis}}.
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To trigger the initiation of the cell cycle, an {{c1::extracellular signal}} is required, done via {{c2::tyrosine kinases}}. The {{c1::signal}} is in …
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P53 is a {{c1::protein}} that regulates the {{c1::G1/S checkpoints}}.
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