Notes in MtM VII (TCA cycle and Phosporylation)

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Published	11/11/2024	A nmenonic for the TCA cycle is: {{c1::Our City Is Kept Safe and Sound From Malice}}. (Skip if you don't want to use it)
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Published	11/11/2024	{{c1::NAD+}} is derived from {{c2::Vitamin B3}}, acts as a coenzyme. Oxidation of an {{c1::NADH molecule}} generates {{c2::2.5}} ATP molecules.
Published	11/11/2024	{{c1::FAD}} is a {{c2::prosthetic}} group, which is {{c2::covalently}} bonded to {{c2::succinate dehydrogenase}}, which is bound to the {{c2::inner mi…
Published	11/11/2024	Explain the TCA cycle. (9 points) (only intermediates)
Published	11/11/2024	Glycolisis occurs in {{c1::cytosol}}.
Published	11/11/2024	What are the 3 irreversible parts of the TCA cycle?
Published	11/11/2024	{{c2::Pyruvate Dehydrogenase}} is catalyst of the conversion of {{c1::pyruvate}} into {{c1::acetyl CoA}}, producing {{c1::NADH and CO2 }} as side…
Published	11/11/2024	{{c2::Citrate Synthase}} is catalyst of the conversion of {{c1::Oxaloacetate}} and {{c2::Acetyl CoA}} into {{c1::Citrate}}.
Published	11/11/2024	{{c1::Aconitase}} catalyses the conversion of {{c2::Citrate}} into {{c2::Isocitrate}}.
Published	11/11/2024	{{c2::Isocitrate dehydrogenase}} catalyses the conversion of {{c1::Isocitrate}} to {{c1::\(a\)-Ketoglutarate}}, producing {{c1::NADH and CO2}} as…
Published	11/11/2024	{{c2::\(a\)-Ketoglutarate Dehydrogenase}} catalyses the conversion of {{c1::\(a\)-Ketoglutarate}} to {{c1::Succinyl CoA}}, forming {{c1::NAD…
Published	11/11/2024	{{c2::Succinyl-CoA Synthetase}} catalysing {{c1::Succinyl CoA}} into {{c1::Succinate}}, forming {{c1::GTP}} as a side products.
Published	11/11/2024	{{c2::Succinate Dehydrogenase}} catalyses {{c1::succinate}} into {{c1::fumarate}}, producing {{c1::FADH2 }} as side products.
Published	11/11/2024	{{c1::Fumarase}} catalyses {{c2::Fumarate}} into {{c2::Malate}}.
Published	11/11/2024	{{c2::Malate Dehydrogenase}} catalyses {{c1::Maltate}} into {{c1::Oxaloacetate}}, forming {{c1::NADH}} as a side product.
Published	11/11/2024	Pyruvate dehydrogenase is inhibited by {{c1::ATP}}, {{c1::acetyl-CoA}} and {{c1::NADH}}.
Published	11/11/2024	Isocitrate dehydrogenase is inhibited by {{c1::ATP}} and {{c1::NADH}}.
Published	11/11/2024	a-ketoglutarate dehydrogenase is inhibited by {{c1::ATP}}, {{c1::NADH}} and {{c1::succinyl-CoA}}.
Published	11/11/2024	The 3 different inhibitable TCA enzymes are {{c1::Pyruvate dehydrogenase}}, {{c1::Isocitrate dehydrogenase}} and {{c1::\(a\)-Ketoglutarate dehydrogena…
Published	11/11/2024	Name 3 Intermediates of TCA pathways can be used for other metabolic pathways.
Published	11/11/2024	{{c1::Anaplerotic reactions}} are {{c2::those that regenerate glycolysis and TCA cycle intermediates}}.
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