Notes in Receptors

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Published 08/28/2024 {{c1::GPCR}} signaling: an external ligand binds to a receptor, which activates an intracellular {{c2::GTP-binding protein,}} which regulates an …
Published 08/28/2024  A {{c2::receptor enzyme (eg. tyrosine kinase): }}a. ligand binding activates {{c1::tyrosine kinase}} activity by {{c2::autophosphorylation}…
Published 08/28/2024 Gated ion channel: channel opens or closes in response to {{c1::concentration of signal ligand}} or {{c1::membrane potential. }}
Published 08/28/2024 Nuclear receptor:{{c1::hormone}} binding allows the receptor to regulate {{c1::expression of specific genes. }}
Published 08/28/2024 Six properties of signal transduction systems
Published 08/28/2024 A GPCR has {{c1::seven}} transmembrane domain proteins, which have a relationship with {{c1::heterotrimeric G proteins. }}
Published 08/28/2024 In step 1 of GPCR signal transduction: 1. Gs with {{c1::GDP}} bound is turned off (cannot activate {{c1::adenylyl cyclase}}). 
Published 08/28/2024 In step 2 of GPCR signal transduction: Contact of Gs with hormone-receptor complex causes displacement of bound {{c1::GDP}} by {{c1::GTP}}.&…
Published 08/28/2024 In step 3 of GPCR signal transduction, Gs with GTP bound dissociates into beta-gamma and alpha subunits. {{c1::Gs-alpha}} is turned on,…
Published 08/28/2024 In step 4 of GPCR signal transduction, GTP bound to Gs-alpha is {{c1::hydrolyzed by protein's intrinsic GTPase}}, and is turned off. Inactiv…
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Published 08/28/2024 What are four examples of second messengers? 
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Published 08/28/2024 An alternative signal transduction through another Galpha-q receptor: 1. hormone binds receptor2. occupied receptor causes {{c1::GDP-GT…
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Published 08/28/2024 A guanylyl cyclase is an example of a {{c2::receptor enzyme. }}Guanylyl cyclase functions by activation of an {{c1::intracellular catalytic (cGMP…
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Published 08/28/2024 Different receptor types can interact with one another ({{c1::cross-talk}}) to exert a wide variety of effects on the cell. 
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