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Receptors
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08/28/2024
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{{c1::GPCR}} signaling: an external ligand binds to a receptor, which activates an intracellular {{c2::GTP-binding protein,}} which regulates an …
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A {{c2::receptor enzyme (eg. tyrosine kinase): }}a. ligand binding activates {{c1::tyrosine kinase}} activity by {{c2::autophosphorylation}…
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Gated ion channel: channel opens or closes in response to {{c1::concentration of signal ligand}} or {{c1::membrane potential. }}
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Nuclear receptor:{{c1::hormone}} binding allows the receptor to regulate {{c1::expression of specific genes. }}
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Six properties of signal transduction systems
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A GPCR has {{c1::seven}} transmembrane domain proteins, which have a relationship with {{c1::heterotrimeric G proteins. }}
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In step 1 of GPCR signal transduction: 1. Gs with {{c1::GDP}} bound is turned off (cannot activate {{c1::adenylyl cyclase}}).
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In step 2 of GPCR signal transduction: Contact of Gs with hormone-receptor complex causes displacement of bound {{c1::GDP}} by {{c1::GTP}}.&…
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In step 3 of GPCR signal transduction, Gs with GTP bound dissociates into beta-gamma and alpha subunits. {{c1::Gs-alpha}} is turned on,…
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In step 4 of GPCR signal transduction, GTP bound to Gs-alpha is {{c1::hydrolyzed by protein's intrinsic GTPase}}, and is turned off. Inactiv…
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What are four examples of second messengers?
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An alternative signal transduction through another Galpha-q receptor: 1. hormone binds receptor2. occupied receptor causes {{c1::GDP-GT…
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A guanylyl cyclase is an example of a {{c2::receptor enzyme. }}Guanylyl cyclase functions by activation of an {{c1::intracellular catalytic (cGMP…
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Different receptor types can interact with one another ({{c1::cross-talk}}) to exert a wide variety of effects on the cell.
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