Notes in Drug Development

To Subscribe, use this Key

Status	Last Update	Fields
Published	09/07/2023	A {{c1::pathogen}} is an organism that cause diease to its host
Published	09/07/2023	{{c1::Virulence}} is the {{c2::severity of disease}} a pathogen causes
Published	09/07/2023	Bacteria can be subclassed into {{c1::gram negative}} and {{c1::gram positive}}.
Published	09/07/2023	What are the classifications of a virus?
Published	09/07/2023	What are the classifications of fungi?
Published	09/07/2023	Prokaryotes are only {{c1::unicellular}}, {{c2::do not have}} a nucleus, are {{c3::without}} membrane bound organelles, contain {{c4::circular}} DNA, …
Published	09/07/2023	Prokaryotic ribosomal subunits are {{c1::30S, 50S}} resulting in a {{c2::70S}} ribosome
Published	09/07/2023	Eukaryotic ribosomal subunits are {{c1::40S, 60S}} resulting in a {{c2::80S}} ribosome
Published	09/07/2023	Eukaryotes are both {{c1::multi and unicellular}}, {{c2::do}} have a nucelus, have {{c3::chromosomal}} DNA, {{c4::do not}} have a cell wall,
Published	09/07/2023	Eukaryotic cells divide via {{c1::mitosis,}} while prokaryotic cells divide via {{c2::binary fission}}
Published	09/07/2023	Obligate anaerobes
Published	09/07/2023	Obligate aerobes
Published	09/07/2023	Facultative aerobes
Published	09/07/2023	Unique features of gram-positive bacteria
Published	09/07/2023	Unique features of gram-negative bacteria
Published	09/07/2023	Due to their {{c1::outer membrane}}, {{c2::Gram-negative}} bacteria contain {{c3::endotoxins}}
Published	09/07/2023	Process of gram-staining
Published	09/07/2023	{{c1::Pilli}} allow for bacteria to {{c2::adhere to cell surfaces}}
Published	09/07/2023	{{c1::Flagella}} allow for bacteria to {{c2::be motile }}
Published	09/07/2023	The {{c1::cell wall}} of bacteria protects against osmotic pressure damage.
Published	09/07/2023	{{c1::Spores}} help organisms resist dehydration, heat, and chemicals
Published	09/07/2023	The {{c1::bacterial capsule}} is a polysaccharide layer that protect against phagocytosis
Published	09/07/2023	The {{c1::glycocalyx}} is a {{c2::network of polysaccharides that mediate adherence to surfaces }}
Published	09/07/2023	Cellular features of a virus
Published	09/07/2023	{{c2::Ergosterol}} is an essential component of the {{c1::fungal}} cell membrane
Published	09/07/2023	{{c2::Fungi}} have a cell wall made primarily of {{c1::chitin}}
Published	09/07/2023	{{c2::Yeast}} are mostly {{c1::unicellular}} with {{c3::buds}} while {{c2::molds}} are {{c1::multicelluar}} with {{c3::filamentous hyphae}}
Published	09/07/2023	What are the key factors to consider when developing an antimicrobial for certain disease?
Published	09/07/2023	The {{c1::minimum inhibitory concentration (MIC)}} is the the {{c2::lowest concentration of a drug}} that prevents visible in vitro growth of a p…
Published	09/07/2023	Process of determining MIC:
Published	09/07/2023	{{c2::Selective toxicitiy}} is the aim to {{c1::kill or inhibit the infecting organism without damaging the host}}
Published	09/07/2023	What are some patient safety considerations when designing or prescribing a drug?
Published	09/07/2023	The {{c1::breakpoint}} is the highest plasma concentration of the drug that can be safely achieved in a patient to define susceptibility to an organis…
Published	09/07/2023	{{c1::Susceptibility}} -> MIC is {{c2::less than}} the breakpoint for the organism -> antibiotic should be effective
Published	09/07/2023	{{c1::Intermediate}} -> MIC is {{c2::about}} the breakpoint for the organism -> antibiotic may be more effective in higher does
Published	09/07/2023	{{c1:: Resistant}} -> MIC is {{c2::greater than}} the breakpoint for the organism -> antibiotic would not be effective
Published	09/07/2023	How does site of infection affect drug levels at that location?
Published	09/07/2023	{{c1::Bacteriostatic}} agents prevent bacterial growth but do not kill the organisms
Published	09/07/2023	{{c1::Bacteriocidal}} agents kill the target bacteria
Published	09/07/2023	Why is it difficult to make anti-virals?
Published	09/07/2023	Why are combination treatments often preferred?
Published	09/07/2023	{{c1::Echinocandins}} target the cell wall of fungi by {{c2::inhibiting glucan synthesis}}
Published	09/07/2023	{{c2::Polyenes and azoles}} target the cell membrane of fungi by {{c1::binding and inhibiting ergosterol}}, respectively.
Status	Last Update	Fields