Notes in g. Enzyme Kinetics

To Subscribe, use this Key

Status	Last Update	Fields
Published	07/28/2024	The steady state assumption assumes?
Published	07/28/2024	The Michaelis-Menten equation states:
Published	07/28/2024	A {{c1::competitive}} inhibitor binds at the same site as the substrate and competes with the substrate for binding to the active site
Published	07/28/2024	A {{c1::noncompetitive}} inhibitor binds to a site other than the active site but prevents the enzyme from adopting a conformation that is requir…
Published	07/28/2024	a609ed1f88b640b4a006e1b154388c8f-ao-1
Published	07/28/2024	a609ed1f88b640b4a006e1b154388c8f-ao-2
Published	07/28/2024	a609ed1f88b640b4a006e1b154388c8f-ao-3
Published	07/28/2024	a609ed1f88b640b4a006e1b154388c8f-ao-4
Published	07/28/2024	{{c1::Suicide}} inhibition uses substrate mimics that irreversibly modify an enzyme's active site
Published	07/28/2024	dTMP is formed from dUMP through the action of the enzyme {{c1::thymidilate synthase}}
Published	07/28/2024	Thymidilate synthase uses the cofactor {{c1::N5,N10-Methylene-THF}} to methylate dUMP, forming dTMP
Published	07/28/2024	During the activity of thymidilate synthase, {{c1::N5,N10-methylene-THF}} is the methyl donor in dTMP synthesis
Published	07/28/2024	{{c1::FdUMP}} is a {{c2::suicide}} inhibitor used to terminate {{c3::thymidilate synthase}} methylation of dUMP to dTMP
Published	07/28/2024	{{c1::Dihydrofolate reductase}} is the enzyme responsible for converting dihydrofolate to tetrahydrofolate
Published	07/28/2024	What 3 factors contributes to the reactivity of Serine proteases?
Published	07/28/2024	HIV synthesisizes its proteins as {{c1::polyproteins}}
Published	07/28/2024	The active sites of both monomers of the HIV protease dimer contain {{c1::aspartate}} residues.
Published	07/28/2024	{{c1::Indinavir}} is a {{c2::peptidomimetic competitive inhibitor}} used in the treatment of {{c2::HIV}} and is an example of structure aided des…
Published	07/28/2024	{{c1::Zymogens}} are the inactive precursors of enzymes
Published	07/28/2024	Chymotrypsinogen is activated by {{c1::trypsin}}
Published	07/28/2024	Trypsinogen is activated by {{c1::enteropeptidase}}
Published	07/28/2024	Proelastase is activated by {{c1::trypsin}}
Published	07/28/2024	Procarboxypeptidase is activated by {{c1::trypsin}}
Published	07/28/2024	Prolipase is activated by {{c1::trypsin}}
Published	07/28/2024	Fibrinogen is activated by {{c1::thrombin}}
Published	07/28/2024	Thimidylate synthase uses {{c1::cysteine}} sidechain for catalysis
Published	07/28/2024	How does FdUMP inhibit dTMP biosynthesis?
Published	07/28/2024	What are two ways to inhibit dTMP biosynthesis?
Published	07/28/2024	Dihydrofolate reductase uses cofactor {{c1::NADPH}} to convert DHF into THF • {{c1::Methotrexate}} is a competitive inhibitor of DHFR • Anticancer age…
Published	07/28/2024	How can serine proteases be inhibited?
Published	07/28/2024	Oxyanion hole stabilizes {{c1::tetrahedral intermediate}} of serine proteases by {{c1::H bonding}} from {{c1::amide hydrogens}} of the enzym…
Published	07/28/2024	How are specifity pockets of chymotrypsin, trypsin and elastase organized?
Published	07/28/2024	HIV proteases cleaves at carboxy terminus of {{c1::hydrophobic}} amino acids
Published	07/28/2024	HIV protease is a {{c1::dimer::monomer/dimer}}. It contains 2 {{c1::ASP}} residues that catalyze through {{c1::General Acids/General Bases}} mech…
Published	07/28/2024	Activation of chymotripsinogen requires formation of ionic bond between {{c2::the N-terminus of Ile16}} and {{c1::Asp 194}} after cleavage
Published	07/28/2024	Three residues involved in polymerization of fibrin are {{c1::Gly-His-Arg}}
Published	07/28/2024	Two pathways involved in blood clotting are {{c1::intrinsic}} and {{c1::extrinsic}} pathways. Both involve {{c1::serine}} proteases
Published	07/28/2024	Penicillin inhibits {{c1::bacterial wall synthesis by suicide inhibition}} thereby preventing glycopeptide transpeptidase from forming the pentaglycin…
Status	Last Update	Fields