Notes in Fate of Cholesterol

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Published 08/28/2024 What molecular dysfunction causes Familial Hypercholesterolemia?v [{{c1::LDL Rs}}]Cells can't {{c1::uptake}} cholesterol from LDL, & liver can't&n…
Published 08/28/2024 How would you treat Familial Hypercholesterolemia?Homozygotes (absolutely no Rs): {{c1::Liver transplant (which would have LDL Rs)}}Heterozy…
Published 08/28/2024 Which fatty acid is the parent to all eicosanoids?{{c1::Arachidonic Acid}}, cut off of {{c1::Phospholipids}} via {{c1::Phospholipase-A2}}
Published 08/28/2024 What are eicosanoids?Signaling molecules (20C) made from {{c1::arachadonic acid::polyunsaturated FA}}Since hydrophobic, only really do {{c1:…
Published 08/28/2024 What enzyme turns arachidonic acid --> Prostaglandin H2?{{c1::COX-1 & 2}}
Published 08/28/2024 How does Aspirin work?Binds to {{c1::COX-2::Receptor}} as a {{c1::competitive} inhibitor.Thus, {{c1::COX-2::R}} can't make {{c1::Prostagland…
Published 08/28/2024 Why can Aspirin / NSAIDs destroy your stomach lining?While NSAIDs --| COX-2, they also --| COX-1 --> {{c1::maintain stomach mucosa (gastroprot…
Published 08/28/2024 What is the precursor of Eicosanoids?{{c1::arachidonate}}BONUS, what are the two things it can directly turn into?{{c1::leukotrienes and prostaglandin…
Published 08/28/2024 Inhibition of {{c1::HMG-CoA reductase::enzyme}} shuts down hepatic cholesterol synthesis
Published 08/28/2024 Statins are {{c1::competitve inhibitors::type of inhibitor}} of HMG CoA Reductase. Statins therefore shut down hepatic cholesterol synthesis.
Published 08/28/2024 Prostaglandin H2 synthase is anchored to which cellular organelle?{{c1::ER-membrane}}
Published 08/28/2024 What is the proposed mechanism as to why COX-2 selective inhibitors have a higher incedence of heart attacks and strokes?{{c1::It pushes more PGH2 to …
Published 08/28/2024 Where can you find COX-1?{{c1::most tissues}}Where can you find COX-2?{{c1::found at sites of inflammation}}
Published 08/28/2024 What is the primary function of COX-1?{{c1::maintain normal lining of stomach and intestines}}What is the primary function of COX-2?{{c1::inflammatory…
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