Notes in j. RNA Processing

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Published	07/28/2024	Eukaryotic RNA is processed via what 3 mechanisms?
Published	07/28/2024	pre-mRNA processing occurs in the {{c1::nucleus}}
Published	07/28/2024	Pre-MRNA capping is characterized by a methyl-guanosine connected to the 5' end of the primary transcript via a {{c1::5' to 5' triphosphate}} linkage
Published	07/28/2024	The {{c1::7}}-nitrogen position is methylated in a {{c1::7'}}-methyl-guanosine cap which is attached at the {{c2::5'}} end of the primary transcr…
Published	07/28/2024	What are the three major function of the 5' methyl guanosine cap?
Published	07/28/2024	Some of the capping, splicing, and polyadenylation factors associate with the {{c1::C-terminal}} domain of RNA Polymerase II - these processess o…
Published	07/28/2024	{{c1::Exons}} are the pre-mRNA sequence elements that remain in the mRNA
Published	07/28/2024	{{c1::Introns}} are the pre-mRNA sequence elements that are removed
Published	07/28/2024	What are the 3 cricital cis sequence elements in the pre-mRNA used for RNA splicing?
Published	07/28/2024	{{c1::Spliceosomes}} are made up of small nuclear RNAs (snRNAs)/and small nuclear ribonucleoprotein complexes that catalyze intron excision
Published	07/28/2024	What are the 2 main steps catalyzed by splicesomes for the excision of introns?
Published	07/28/2024	What two key cis elements are required in pre-mRNA for polyadenylation to occur?
Published	07/28/2024	What two key proteins associate with the C-terminal tail of RNA polymerase II and are used for polyadenylation of pre-mRNA?
Published	07/28/2024	The enzyme {{c1::poly-A polymerase}} is responsible for synthesizing the polyadneylated tail of pre-mRNA
Published	07/28/2024	What are three RNA processing mechanisms for diversifying the products generated from a single pre-mRNA?
Published	07/28/2024	miRNA is transcribed by
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Published	07/28/2024	The 70-nt pre-miRNA hairpin is cleaved from the initial pre-miRNA by {{c1::DROSHA}}
Published	07/28/2024	The pre-miRNA is exported from the nucleus by {{c1::Exportin 5}}
Published	07/28/2024	The pre-miRNA hairpin is cleaved in the cytoplasm by {{c1::DICER}}
Published	07/28/2024	Mature 22-nt miRNA binds to Argonaute and other proteins to form the {{c1::RISC (RNA-induced silencing complex)}} , where one of the strands of miRNA …
Published	07/28/2024	{{c1::Perfect}} complementarity of miRNA to mRNA leads to mRNA {{c2::degradation}}
Published	07/28/2024	{{c1::Imperfect}} pairing of miRNA to mRNA leads an {{c2::inhibition of mRNA translation}}
Published	07/28/2024	XIST is an example of a {{c1::long non-coding}} RNA
Published	07/28/2024	lncRNAs are transcribed by RNA polymerase {{c1::II}}
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