Notes in Li L05 Capsules

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Published	10/11/2023	Capsules (Slide 1)USP Definition“Capsules are solid dosage forms in which the drug substance and/or excipients are {{c1::enclosed}} within a…
Published	10/11/2023	Capsule Dosage Forms (Slide 3)Advantages (6)They have better {{c1::bioavailability}} and faster {{c1::onset}} than tabletsThey are ideal for…
Published	10/11/2023	Capsules (Slide 4)Types of Capsules{{c1::Hard gelatin}} capsules – most common{{c1::Soft gelatin}} capsules{{c1::Starch}} capsules {{c1…
Published	10/11/2023	Gelatin NF (Slide 5)Gelatin for capsules comes from {{c1::partially hydrolyzed collagen of animal skin}}, {{c1::white connective tissue}}, and {{c1::b…
Published	10/11/2023	Properties of Gelatin (Slide 6)Gelatin is...Insoluble in {{c1::cold water}}Soluble in {{c1::hot water, warm gastric fluid}}{{c1::Tasteless}}{{c2:…
Published	10/11/2023	Water Content (Slide 7)< {{c1::5%}} = brittle{{c1::13-16%}} = hard capsuleA {{c1::desiccant}} is usually used in the containers, red…
Published	10/11/2023	Hard Gelatin Capules (Slide 8)Consists of a {{c1::cap}} and {{c1::body}}{{c1::Body}} is for containing the content{{c1::Cap}} is for keeping the …
Published	10/11/2023	Various Types of Capsules 3 Examples (Slide 10){{c1::Coni-Snap, Coni-Snap Supro}}snap together to seal{{c1::Kapseal}}utilizes a seal that locks cap to…
Published	10/11/2023	Size of Gelatin Capsules (Slide 13)As numbers {{c1::increase}}, volume contained {{c1::decreases}} (same relationship with vaccine gauges)
Published	10/11/2023	Selection of Capsule Size (Slide 16)Selection of Capsule Size is dependent on the {{c1::amount/bulk of the drug and inert substances}} needed and the …
Published	10/11/2023	Pharmaceutic Ingredients in Capsules (Slide 17){{c1::Diluents}}: lactose, microcrystalline cellulose{{c1::Lubricants}}: magnesium stearate, calcium st…
Published	10/11/2023	Modified-Release Capsules (Slide 20)Enteric-coated capsulesCoated multiparticulates (content)Two Types of Modified-Release CapsulesDelayed-releaseUtil…
Published	10/11/2023	Extemporaneous Compounding (Slide 21)Extemporaneous Compounding is the {{c1::filling of hard gelatin capsules}}It is especially useful for making caps…
Published	10/11/2023	Soft Gelatin Capsules (Slide 25)One-piece hermetically sealed (airtight) dosage formGelatin shells containing glycerin or polyhydricalcohol as {{c1::p…
Published	10/11/2023	Soft Gelatin Capsules (Slide 26)Contents for Soft Gelatin Capsules include (5):{{c1::Liquids}}{{c1::Suspensions}}{{c1::Pasty Materials}}{{c1::Dry Powd…
Published	10/11/2023	Shape of Soft Gelatin CapsulesShapes of Soft Gelatin Capsules include (4):{{c1::Sphere}}{{c1::Oblong}}{{c1::Eclipse}}{{c1::Tube}}-shape
Published	10/11/2023	Compatibility (Slide 30)The compatibility between shells of Soft Geltain Capsules and Drugs/Contents is dependent on the:{{c1::hydrolysis}} of the dru…
Published	10/11/2023	Liquids that can be Encapsulated in Soft Gelatin Capsules include (3):(Slide 31){{c1::Oil}} or {{c1::hydrophobic}} liquids{{c1::Hydrophilic …
Published	10/11/2023	Starch Capsules (Slide 32):Properties of Starch Capsules They are {{c1::natural}}They are {{c1::free of animal products}} (unlike gelatin)They ar…
Published	10/11/2023	Hand Seal Starch CapsuleWet a Q-Tip in the Sealing Solution (80% Water, 20% Ethanol)Apply to the body of the capsuleimmediately {{c1::seal}} with the …
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