Notes in Signal Transduction 2

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Published	09/07/2023	{{c1::Single membrane, enzyme linked receptors}} cross the plasma membrane once, have ligand binding sites on their extracellular domains, and have in…
Published	09/07/2023	Many single membrane, enzyme linked receptors bind {{c1::growth factors:: type of ligand}}
Published	09/07/2023	Receptor tyrosine kinases (RTKs) are an example of {{c1::single membrane, enzyme linked receptors}}
Published	09/07/2023	When RTKs dimerize, {{c1::autophosphorylation events}} occur on their own intracellular kinase domains
Published	09/07/2023	Once intracellular kinase domains of RTKs are phosphorylated, they serve as {{c1::"docking stations"}} for other intracellular proteins
Published	09/07/2023	{{c1::Src homology (SH) domains}} contribute to protein binding at the RTK "docking stations"
Published	09/07/2023	{{c1::SH2}} domains provide versatility for protein-protein interactions
Published	09/07/2023	{{c1::SH3}} domains bind proline rich regions in intracellular proteins
Published	09/07/2023	{{c1::Ras}} is a monomeric G protein bound on intracellular side of plasma membrane that mediates signals from RTKs and activates {{c2::mitogen-activa…
Published	09/07/2023	{{c1::Single membrane, enzyme coupled receptors}} cross the plasma membrane only once, and ligand binding causes phosphorylation of a cytoplasmic tyro…
Published	09/07/2023	Cytoplasmic tyrosine kinases have multiple families, including: {{c1::Src}}, {{c1::Fak}}, {{c1::Abl}}, and {{c1::Jak}}
Published	09/07/2023	Single membrane, enzyme coupled receptors play an important role in the {{c1::immune system}}, specifically in lymphocytes, integrins, and cytokines
Published	09/07/2023	JAK (Jakus kinase) is an example of a kinase that forms a {{c1::stable association}} with a single membrane, enzyme coupled receptor
Published	09/07/2023	STAT (Signal Transducers & Activators of Transcription) are proteins that r{{c1::egulate gene transcription}} after being activated by {{c2::JAK}}…
Published	09/07/2023	{{c1::Protein tyrosine phosphatase}} reverses tyrosine phosphorylation
Published	09/07/2023	{{c1::Serine/Threonine protein phosphatases}} reverse serine and threonine phosphorylation
Published	09/07/2023	{{c1::Nuclear receptors}} are a unique type of recepter because they are located inside the cell and bind ligands that cross the cell membrane
Published	09/07/2023	{{c1::Rheumatoid arthritis}} is an autoimmune disease with symptoms of pain or aching in more than one joint, stiffness in more than one joint, tender…
Published	09/07/2023	Risk factors of rheumatoid arthritis include {{c1::genetics:: hereditary}}, {{c2::smoking:: common risk factor in many disease}}, and {{c3::being fema…
Published	09/07/2023	Rheumatoid arthritis is characterized by inflammation of {{c1::synovial fluid/joints}} due to the immune system losing tolerance to proteins that cont…
Published	09/07/2023	Low dose {{c1::methotrexate}} is the gold standard treatment for rheumatoid arthritis
Published	09/07/2023	Genetic factors that influence signal transduction of renin transcription in baroreceptor cells may contribute to {{c1::hypertension}}
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