Notes in 03. Herpes Virus Infections

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Status	Last Update	Fields
Published	06/26/2023	Herpesviridae → structure and function 4 layered Structure Core → {{c1::dsDNA}}Capsid → Icosahedral (20 faces) Tegument → {{c…
Published	06/26/2023	Human Herpes Viruses → {{c1::enveloped}}, dsDNA viruses HHVHH2 HHV → {{c1::varicella zoster virus}}HHV-4A and 4B → {{c1::EBV}}HHV-…
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Published	06/26/2023	8b9d508717914454988b61d8cc8d9c99-oa-8
Published	06/26/2023	Herpesviridae Viruses Enveloped viruses spread by {{c1::direct contact}}labile on surfaces, does not form fomites Lytic and Latent infe…
Published	06/26/2023	Infectious Mononucleosis US adult {{c1::EBV}} Seroprevalence Organism → {{c1::EBV}} reservoir → {{c1::humans}} through {…
Published	06/26/2023	Mononucleosis Signs and Symptoms Triad {{c1::Fever}} w/ a duration of {{c1::10-14 days}}{{c1::Lymphadenopathy}} in the location of&nbsp…
Published	06/26/2023	Mononucleosis Lab Abnormalities CBC → >{{c1::50% lymphocytes}} Peripheral blood smear → >{{c1::10% atypical lymphocytes}}CMP → {{…
Published	06/26/2023	mononucleosis → DDX {{c1::Viral pharyngitis}} Group A strep pharyngitis Acute HIV infection Malaise w/ increased LFTs CMV, Vi…
Published	06/26/2023	Mononucleosis → Diagnosis and TreatmentClinical presentation, CBC Heterophile Ab tests {{c1::Monospot}} will be positive in {{c1::2nd}}…
Published	06/26/2023	mononucleosis → treatment {{c1::Splenic}} rupture Highest risk in weeks {{c1::2nd and 3rd}} 70% in males 50% of cases are spo…
Published	06/26/2023	EBV Clinical Pearls → PANCE Classic symptom triad and malaise in adolescent {{c1::Fever, pharyngitis w/ tonsillar exudates, and posterior ce…
Published	06/26/2023	Cytomegalovirus US seroprevalence → 40-70% as adults organism → CMV, {{c1::HHV-5}}, beta subfamily Reservoir → {{c1::humans}}…
Published	06/26/2023	CMV signs and symptoms most immunocompetent adults are ASx or can have {{c1::mild malaise}}, low grade {{c1::fever}} → symptoms like in…
Published	06/26/2023	CMV → diagnosis infants PCR testing of {{c1::urine}} or {{c1::saliva}} 2-3 weeks after birth IgM though less sensitive Adults&nbsp…
Published	06/26/2023	CMV → DDx fever, hepatitis, pneumonitis, retinitis, colitis, encephalitis {{c1::Various viral infxs}} Hepatitis Autoimmune conditi…
Published	06/26/2023	CMV treatment options Inhibition of {{c1::DNA polymerase}}{{c1::Ganciclovir}} → first line agentnucleoside anaolog inhibits kinases that cat…
Published	06/26/2023	Monitoring of CMV tx {{c1::Baseline}} viral load then check {{c1::weekly}}D/C tx once negative viral load Persistence of virus followin…
Published	06/26/2023	CMV Clinical Pearls → PANCE transmission → {{c1::vertical}}pts → {{c1::organ transplant}} and HIV pts Many clinical symptoms simil…
Published	06/26/2023	HSV and Herpes Zoster Treatment 1st episode → immunocompetent Patient {{c1::Acyclovir}} → (200mg caps, 400 mg and 800 mg tabs) Oral HSV…
Published	06/26/2023	random Dougie fact → way more likely to get EBV from {{c1::influenza itself}} vs {{c1::influenza vacx}}
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