Notes in Blood Disorders Overview (15)

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Published 11/11/2023 {{c1::Anemia}} ‒ inadequate RBC mass 
Published 11/11/2023 {{c1::Polycythemia}} ‒ Too much RBC mass
Published 11/11/2023 Clinical presentations of anemias
Published 11/11/2023 {{c1::Thalassemia}} is a deficiency in {{c2::globin}} synthesis 
Published 11/11/2023 Morphologic diangosis of anemia 
Published 11/11/2023 {{c2::Hematocrit}} is normally {{c1::3x}} {{c2::Hemoglobin}} in a lab value
Published 11/11/2023 {{c1::B12}} & {{c1::folate}} deficiencies may affect DNA synthesis and decrease RBC production
Published 11/11/2023 Iron defiency anemia would appear {{c2::{{c1::micro}}cytic}} & {{c2::{{c1::hypo}}chromic }}
Published 11/11/2023 {{c1::Transferrin}} transports Fe in the blood 
Published 11/11/2023 Storage pools of Iron in the body 
Published 11/11/2023 {{c1::Hepcidin}} inhibits iron transfer from enterocytes to plasma 
Published 11/11/2023 {{c1::⇧}} Hepcidin = {{c2::⇩}} Fe absorption into blood = {{c2::⇩}} Fe availability 
Published 11/11/2023 TBIC = {{c1::Total}} {{c1::Iron}} {{c1::Binding}} {{c1::Capacity}} 
Published 11/11/2023 Iron deficiency anemia have a TIBC of < {{c1::1:5}}
Published 11/11/2023 Causes of Iron Deficiency 
Published 11/11/2023 Clinical sequelae of Iron Deficiency 
Published 11/11/2023 Poikocytosis ‒ ⇧ variability of cell shape
Published 11/11/2023 Anemias resulting from chronic inflammation
Published 11/11/2023 Inflammatory cytokines (e.g., IL-6) {{c1::increase::⇧ or ⇩}} hepcidin production → {{c1::decrease::⇧ or ⇩}} Fe absorption from gut and {{c1::decr…
Published 11/11/2023 Megaloblastic anemia
Published 11/11/2023 Appearance of Megablastic anemia 
Published 11/11/2023 Possible causes of megablastic anemia 
Published 11/11/2023 {{c1::Pernicious anemia}} is megablastic anemia where autoantibodies are directed against {{c2::Intrinsic Factor}} or {{c2::parietal cells}}
Published 11/11/2023 Anemia associated with Thalassemia result from ⇩ RBC {{c1::production}} &  ⇩ {{c1::lifespan}}
Published 11/11/2023 Morphology of Thalassemia 
Published 11/11/2023 Appearance of reticulocytosis 
Published 11/11/2023 Intrinsic factor is secreated in the {{c1::stomach}} and complexes with {{c2::B12}}, which is then absorbed in the {{c1::ileum}}
Published 11/11/2023 Acute myeloid leukemias 
Published 11/11/2023 {{c1::Myeloid neoplasms}} stem from the common progenitor cells of the tridsja j lineage
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