Notes in 05_Immunotherapy

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Published	02/10/2024	Agents used to Inhibit T Cell Activation for Treatment of Graft Rejection {{c1::Anti-IL-2R (Basiliximab and Daclizumab)}} {{c1::Anti-T-Cell and Anti-C…
Published	02/10/2024	Low doses of {{c1::Corticosteroids}} predominantly act on {{c2::antigen-presenting cells}}, preventing some of the early stages of graft rejection.
Published	02/10/2024	Higher doses of {{c1::Corticosteroids}} have direct effects on {{c2::T cells}} and are used to treat episodes of rejection
Published	02/10/2024	{{c1::Cyclosporine}} and {{c1::Tacrolimus}} work via {{c2::T-Cell Signalling Blockade}} by interacting with proteins in the intracellular T-cell …
Published	02/10/2024	{{c1::Basiliximab}} and {{c1::Daclizumab}} are agents that completely block {{c2::IL-2}} and are used to treat episodes of acute graft rejec…
Published	02/10/2024	{{c1::Rapamycin}} is an agent that blocks {{c2::IL-2}}, which is less potent than monoclonal antibodies, and used to treat episodes of acute graf…
Published	02/10/2024	{{c1::Methotrexate}}, {{c1::Azathioprine}}, {{c1::Mycophenolate}} and {{c1::Mofetil}} are immunosuppressants that inhibit {{c2::DNA production}} …
Published	02/10/2024	Indications of Immunoglobulin Therapy[1] {{c1::Passive Immunity (Bites, Stings, Hypogammaglobulinaemia, Rabies)}}[2] {{c1::Post-Exposure Prophylaxis (…
Published	02/10/2024	{{c1::Intravenous Immunoglobulin (IVIg)}} is a {{c2::plasma-derived IgG is a key biologic for replacement therapy in primary and secondary immunodefic…
Published	02/10/2024	{{c1::Direct immunotherapy}} involves {{c2::antibodies or antibody related fragments that detect an antigen on the tumour cell and destroy the target …
Published	02/10/2024	Examples of {{c2::Direct Immunotherapy}} {{c1::Monoclonal antibodies}} {{c1::Chimeric Antigen Receptors (CARs)}} {{c1::Bi-specific antibodies}}
Published	02/10/2024	{{c1::Indirect immunotherapy}} involves {{c2::activation of the immune system to render it able to seek and destroy tumour cells}}
Published	02/10/2024	Examples of {{c2::Indirect Immunotherapy}} {{c1::Tumour vaccines}} {{c1::Dendritic cell vaccines}} {{c1::Adoptive cell transfer}} {{c1::Cytokine thera…
Published	02/10/2024	{{c1::Rituximab}} is a monoclonal anti-CD20 antibody used for Non-Hodgkin’s Lymphoma (NHL), Rheumatoid Arthritis, SLE
Published	02/10/2024	{{c1::Infliximab}} is an TNF-a inhibitor that is used for Rheumatoid Arthritis, Ankylosing spondylitis, IBD
Published	02/10/2024	{{c1::Trastuzumab (Herceptin)}} and {{c1::Pertuzumab}} are Human Epidermal Growth Factor Receptor 2 (HER2) inhibitors that are used for Breast Ca…
Published	02/10/2024	{{c1::Ipilimumab}} is a CTLA-4 inhibitor that is used for treatment of Melanoma
Published	02/10/2024	{{c1::Pembrolizumab}} and {{c1::Nivolumab}} are Anti-PD1/PD-L1 inhibitors that activate T cells against Tumours
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