Notes in Hemostasis

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Status	Last Update	Fields
Published	07/30/2024	Mechanisms of Vasospasm/constrictionLocal myogenic contraction/reflex{{c1::Endothelin}} from endothelial cells{{c1::Thromboxane A2 & Serotoni…
Published	07/30/2024	3 steps in the platelet plug{{c1::Platelet adhesionPlatelet activationPlatelet aggregation}}
Published	07/30/2024	Platelet Glycoprotein Receptors & LigandsGpIa - {{c1::Collagen}}GpIb - {{c1::vWF}}GpIIb/IIIa - {{c1::Fibrinogen, vWF}}
Published	07/30/2024	Platelet activation starts once the platelets bind to {{c1::collagen}}
Published	07/30/2024	[VR] 1. ADP 2. Platelet activation{{c1::A}}
Published	07/30/2024	[VR] 1. Thromboxane A2 2. Platelet activation{{c1::A}}
Published	07/30/2024	[VR] 1. Serotonin 2. Platelet activation{{c1::A}}
Published	07/30/2024	Changes Induced by Mediators during platelet activation● Metabolism: {{c1::Production of more mediators}}● Cell membrane: {{c2::Increased glycoprotein…
Published	07/30/2024	Mediator that alters surface configuration of circulating platelets during platelet activation{{c1::ADP}}
Published	07/30/2024	Mediator that potentiates platelets adhesion and aggregation{{c1::Thromboxane A2 (TXA2)}}
Published	07/30/2024	[VR] 1. Nitric Oxide 2. Platelet plug formation{{c1::B}}
Published	07/30/2024	Considered as the dominant hemostatic defense (Phase of coagulation){{c1::Secondary Phase}}
Published	07/30/2024	Link between the extrinsic and intrinsic pathways{{c1::Thrombin}}
Published	07/30/2024	The following coagulation factors are cofactors:{{c1::Tissue Factor/III, Ca/IV, Labile Factor/V, Antihemophilic Factor/VIII, and HMWK}}The rest are se…
Published	07/30/2024	Coagulation Factor I or {{c1::Fibrinogen}} is the thrombin substrate
Published	07/30/2024	Coagulation Factor II aka {{c1::Prothrombin}}
Published	07/30/2024	Coagulation Factor III aka {{c1::Tissue Factor/Thromboplastin}}
Published	07/30/2024	Coagulation Factor VIII aka {{c1::Anti-hemophilic Factor}}
Published	07/30/2024	Coagulation Factor IX aka {{c1::Christmas Factor}}
Published	07/30/2024	Coagulation Factor XI aka {{c1::Plasma Thromboplastin Antecedent}}
Published	07/30/2024	Coagulation Factor XII aka {{c1::Hageman Factor}}
Published	07/30/2024	Hemophilia is a Bleeding disorder caused by a lack of factor/s {{c1::8 or 9}}
Published	07/30/2024	The {{c1::extrinsic}} pathway aka Tissue Factor Activation Pathway
Published	07/30/2024	[QC] Rapidity of initiation 1. Intrinsic pathway 2. Extrinsic pathway{{c1::B}}
Published	07/30/2024	Subendothelial damage releasing {{c1::Tissue Factor/IIIa}} into the blood is the trigger for the Extrinsic Pathway
Published	07/30/2024	Extrinsic Tenase Components (In order of the cascade){{c1::Tissue factor/IIIaPro-convertin/Stable Factor/VIIaCa2+}}
Published	07/30/2024	Intrinsic Tenase Components{{c1::Anti-Hemophilic/VIIIaChristmas/IXaCa2+}}
Published	07/30/2024	Intrinsic Pathway Order of Activation{{c1::Hageman Factor/XIIaPlasma Thromboplastin Antecedent/XIaChristmas/IXa}}
Published	07/30/2024	Activation of Hageman Factor/XII Order of Activation{{c1::HMWKHageman Factor/XIIPrekallikrein → KallikreinMore Factor XIIa}}
Published	07/30/2024	Intrinsic tenase and extrinsic tenase activate {{c1::Factor X/Stuart Power}}
Published	07/30/2024	Prothrombinase or Prothrombin Activator Components{{c1::Stuart Power/XaLabile Factor/VaCa2+Phospholipid}}
Published	07/30/2024	Thrombin/IIa activates the following factors: (5){{c1::Fibrinogen/IFibring Stabilizing/XIIIPlasma Thromboplastin Antecedent/XIAnti-Hemophilic/VIIILabi…
Published	07/30/2024	Anti-Hemophilic Factor/VIII is activated by cleaving it from the {{c1::Von Willebrand Factor (vWF)}}
Published	07/30/2024	Phases of hemostasisPrimary{{c1::Vascular spasm/constrictionPlatelet plug formation::2}}Secondary{{c1::Coagulation and clot formation}}Tertiary{{c1::C…
Published	07/30/2024	Coagulation Factor V aka {{c1::Labile Factor}}
Published	07/30/2024	Coagulation Factor X aka {{c1::Stuart Power Factor}}
Published	07/30/2024	Coagulation Factor XIII aka {{c1::Fibrin Stabilizing Factor}}
Published	07/30/2024	Coagulation Factor IV aka {{c1::Calcium}}
Published	07/30/2024	Coagulation Factor VII aka {{c1::Stable Factor/Pro-convertin}}
Published	07/30/2024	Thrombocytopenia is a Bleeding disorder caused by a platelet count of <{{c1::20,000}}
Status	Last Update	Fields