Notes in TB001 Coagulation

To Subscribe, use this Key

Status	Last Update	Fields
Published	10/08/2024	What factors constitute the normal functions of the endothelium to prevent coagulation? (4)
Published	10/08/2024	Describe the co-agulant properties of the endothelium (3)
Published	10/08/2024	{{c1::Platelets}} are the "first responders" at sites of vascular injury
Published	10/08/2024	Describe the molecular mechanism of normal primary hemostasis
Published	10/08/2024	vWF carries {{c1::factor VII}}, a coagulation factor
Published	10/08/2024	Coagulation factors are {{c1::serine proteases}} that activate downstream factors by cleaving {{c2::peptide bonds}}
Published	10/08/2024	{{c2::Factor VII}} activates {{c1::Factor V}}
Published	10/08/2024	{{c2::Factor VIII}} activates {{c1::Factor X}}
Published	10/08/2024	What factors are involved in the contact activation (intrinsic) pathway of the coagulation cascade?
Published	10/08/2024	What factors are involved in the tissue factor (extrinsic) pathway of the coagulation cascade?
Published	10/08/2024	The {{c2::tissue factor (TF) activation}} pathway is activated by {{c1::tissue factor}}
Published	10/08/2024	The {{c2::contact activation}} pathway is activated by {{c1::collagen}}
Published	10/08/2024	What does an elevated partial thromboplastin time (PTT) suggest in the contact activation pathway? (5)
Published	10/08/2024	What does an elevated prothrombin time (PT) suggest in the tissue factor activation pathway? (1)
Published	10/08/2024	{{c2::Factor V}} is a cofactor to {{c1::Factor X}}
Published	10/08/2024	Describe the molecular mechanism of the common pathway in secondary hemostasis
Published	10/08/2024	Coagulation activation takes place on the {{c1::phospholipid membrane of platelets}}
Published	10/08/2024	What does elevated PT/PTT suggest in the common pathway?
Published	10/08/2024	What factors are activated in a thrombin burst?
Published	10/08/2024	How does the activated partial thromboplastic time (aPTT) assay work?
Published	10/08/2024	Describe the aPTT mixing study and how to interpret the results of one
Published	10/08/2024	How does the prothrombin time (PT) assay work?
Published	10/08/2024	Warfarin inhibits the vitamin K epoxide reductase (VKOR) enzyme in the Vitamin K-dependent hepatic synthesis
Published	10/08/2024	What are the common mechanisms for the downregulation of hemostasis? (3)
Published	10/08/2024	{{c2::Antithrombin III (ATIII)}} is a {{c3::serine protease inhibitor}} produced in the liver. It is a major inhibitor that binds {{c1::thrombin}} and…
Published	10/08/2024	{{c2::Heparin}} complexes with {{c1::ATIII}} to increase its activity by 100x
Published	10/08/2024	{{c1::Tissue factor pathway inhibitor (TFPI)}} is a {{c2::serine protease inhibitor}} produced by endothelial cells that primarily targets {{c3::TF}} …
Published	10/08/2024	Describe the mechanism of thrombomodulin (TM)
Published	10/08/2024	Describe the mechanism of fibrinolysis
Published	10/08/2024	{{c1::Plasmin}} is a serum protein that {{c2::dissolves fibrin clots}}
Published	10/08/2024	{{c2::Plasminogen activator inhibitor (PAI-1)}} inhibits {{c1::t-PA}} and prevents {{c1::fibrinolysis}}
Status	Last Update	Fields