Notes in T & B cell Development (11/6)

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Status	Last Update	Fields
Published	11/11/2023	Common Variable Immunodeficiency (CVID)
Published	11/11/2023	B-cell receptors (BCRs) are {{c1::surface immunoglobulins }}
Published	11/11/2023	{{c1::IgM}} & {{c1::IgD}} expressed by {{c2::mature, naive}} B cells
Published	11/11/2023	αβTCRs are membrane bound transmembrane proteins that contains {{c1::2}} variable regions
Published	11/11/2023	BCRs are composed of {{c1::heavy}} & {{c1::light}} chains. {{c1::Light}} chains contains {{c2::2}} domains, {{c2::1}} variable and {{c2::1}} …
Published	11/11/2023	{{c2::Combinatorial Diversity}} is VDJ Region Combinations accomplished by {{c1::RAG}}
Published	11/11/2023	{{c1::Junctional Diversity}} is the difference in the joining regions of lymphocyte receptors and accomplished by the enzyme {{c2::TdT}}
Published	11/11/2023	Two processes in developing TCR & BCR diversity
Published	11/11/2023	{{c1::Allelic Exclusion}} ‒  T and B cells rearrange only one of the antigen receptor domains, ensuring a single antibody specificity
Published	11/11/2023	A defect in {{c1::BTK}} results in X-linked agammaglobulinemia
Published	11/11/2023	Functional defect in X-linked Agammaglobulinemia (XLA)
Published	11/11/2023	{{c1::Common Variable Immunodeficiency (CVID)}} is the most prevelant symptomatic antibody deficiency
Published	11/11/2023	Each T cell expresses only 1 TCR b chain allele and 1 TCR a chain allele, ensuring  a single TCR specificity/cell ({{c1::allelic exclusion}})
Published	11/11/2023	DiGeorge syndrome is {{c1::Selective T cell Deficiency}}
Published	11/11/2023	Functional deficiencies of DiGeorge syndrome
Published	11/11/2023	~{{c1::1}}% of DiGeorge syndrome have no thymus
Published	11/11/2023	Newborn Screeening for {{c2::SCID}} is done via the {{c1::TREC}}
Published	11/11/2023	Patient care for SCID
Published	11/11/2023	{{c1::X-linked}} SCID is the most common form
Published	11/11/2023	Lymphocyte populations in X-linked SCID
Published	11/11/2023	{{c1::Autosomal recessive}} SCID is the most common form of SCID and caused by deficiency in {{c2::adenosine deaminase (ADA)}}
Published	11/11/2023	Lymphocyte populations in autosomal recessive SCID
Published	11/11/2023	{{c2::Omenn}} syndrome results from mutations in {{c1::RAG}} genes and results in narrow {{c1::TCR}} diversity
Published	11/11/2023	Severe mutations in RAG would result in {{c1::SCID}}
Status	Last Update	Fields