Notes in 05_Multiple Myeloma

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Status	Last Update	Fields
Published	02/10/2024	Immunoglobulins are produced by {{c1::B}} cells mostly {{c1::plasma}} cells
Published	02/10/2024	{{c1::Paraprotein}} is a {{c2::monoclonal immunoglobulin present in blood or urine that indicates that there is a monoclonal proliferation of a B lymp…
Published	02/10/2024	Ig{{c2::M}} paraproteins made by maturing B-lymphocytes and are seen in the condition: {{c1::Lymphoma}}
Published	02/10/2024	Ig{{c2::G}} or Ig{{c2::A}} paraproteins made by mature plasma cells and are seen in the condition: {{c1::Myeloma}}
Published	02/10/2024	{{c1::Myeloma}} is {{c2::a neoplastic disorder of plasma cells, resulting usually in excessive production of a single type of immunoglobulin (paraprot…
Published	02/10/2024	Presentation of {{c2::Myeloma}}Remembered as {{c1::I-CRAB}} {{c1::I - Immunoparesis (Hypogammaglobulinaemia: low levels of immunoglobulin)}} {{c1::C -…
Published	02/10/2024	Presentation of {{c2::Low-Grade Lymphoma (IgM Paraprotein)}} {{c1::Bone marrow failure (anaemia, thrombocytopenia)}} {{c1::Lymphadenopathy}} {{c1::Hep…
Published	02/10/2024	Investigation of Immunoglobulins {{c1::Total immunoglobulin levels (Measures Ig subclasses by their heavy chain / Fc section)}} {{c1::Serum protein el…
Published	02/10/2024	Investigations of {{c2::Myeloma}} {{c1::Full Blood Count (Normocytic Anaemia, Neutropenia)}}{{c1::U&Es (shows raised Urea and Creatinine and Hyper…
Published	02/10/2024	Diagnosis of {{c2::Myeloma}} is by {{c1::Bone marrow biopsy showing plasma cells >10% of total bone marrow cell population}}
Published	02/10/2024	If bone marrow aspiration shows that plasma cells are {{c1::<9}}% of the population, then the diagnosis is {{c2::Monoclonal Gammopathy of…
Published	02/10/2024	Management of Symptomatic Myeloma {{c1::Chemotherapy and Steroids}} {{c1::Bisphosphonate therapy (e.g. zoledronic acid)}} {{c1::Radiothera…
Published	02/10/2024	Management of Asymptomatic Myeloma {{c1::Bisphosphonate therapy (e.g. zoledronic acid)}}
Published	02/10/2024	A Special Urine Test is done to aid the diagnosis of {{c1::Myeloma}} which shows {{c2::Bence-Jones Protein}}
Status	Last Update	Fields