Notes in b. RBC Structure and Function

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Status	Last Update	Fields
Published	07/28/2024	a6942057de13437287afb9577819e18d-ao-1
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Published	07/28/2024	a6942057de13437287afb9577819e18d-ao-8
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Published	07/28/2024	a6942057de13437287afb9577819e18d-ao-11
Published	07/28/2024	a6942057de13437287afb9577819e18d-ao-12
Published	07/28/2024	Decreased {{c3::oxygen}} delivery causes peritubular cells in the {{c1::kidney}} to release {{c2::erythropoietin}} to stimulate erythropoies…
Published	07/28/2024	Patients with renal disease do not make sufficienct {{c1::erythropoietin}} in response to anemia, thus exacerbating the problem
Published	07/28/2024	Abnormal and damaged RBCs are removed from circulation via the {{c1::monocular phagocytic system (MPS)}} in the {{c2::spleen}}
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Published	07/28/2024	cfd93d2ab2e843baaeb5207a61980188-ao-4
Published	07/28/2024	Hereditary Spherocytosis can be caused by RBC membrane protein defects in the following 5 proteins and causes it to look like?:
Published	07/28/2024	1a65b8d3f4894665a96e9520f40c071c-ao-1
Published	07/28/2024	1a65b8d3f4894665a96e9520f40c071c-ao-2
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Published	07/28/2024	1a65b8d3f4894665a96e9520f40c071c-ao-4
Published	07/28/2024	1a65b8d3f4894665a96e9520f40c071c-ao-5
Published	07/28/2024	1a65b8d3f4894665a96e9520f40c071c-ao-6
Published	07/28/2024	1a65b8d3f4894665a96e9520f40c071c-ao-7
Published	07/28/2024	1a65b8d3f4894665a96e9520f40c071c-ao-8
Published	07/28/2024	The predominant hemoglobin observed in the embryo is {{c1::zeta2-epsilon2}}
Published	07/28/2024	The predominant hemoglobin observed during fetal development is {{c1::alpha2-gamma2}}
Published	07/28/2024	The predominant hemoglobin observed during the adult life span is {{c1::alpha2-beta2}} with a small portion of {{c2::alpha2-delta2}}
Published	07/28/2024	Heme consists of an iron atom surrounded by a {{c1::porphyrin ring}}. Heme is synthesized in a series of steps in {{c1::immature}} RBCs: Mit…
Published	07/28/2024	{{c1::P50}} is the partial pressure where 50% of hemoglobin is saturated
Published	07/28/2024	Shifting the oxyhemoglobin dissociation curve to the {{c1::right}} causes a {{c2::decrease}} in hemoglobin affinity for O2
Published	07/28/2024	Shifting the oxyhemoglobin dissociation curve to the {{c1::left}} causes a {{c2::increase}} in hemoglobin affinity for O2. At rest, PO2 in t…
Published	07/28/2024	{{c1::Decrease}} in temperature causes a {{c2::increase}} in hemoglobin affinity for O2
Published	07/28/2024	{{c1::Decrease}} in pH causes a {{c2::decrease}} in hemoglobin affinity for O2
Published	07/28/2024	{{c1::Increase}} in pH causes a {{c2::increase}} in hemoglobin affinity for O2
Published	07/28/2024	{{c1::Increase}} in 2-3-biphosphoglycerate causes a {{c2::decrease}} in hemoglobin affinity for O2
Published	07/28/2024	{{c1::Decrease}} in 2-3-biphosphoglycerate (same thing as 2,3 DPG) causes a {{c2::increase}} in hemoglobin affinity for O2
Published	07/28/2024	{{c1::Decrease}} in P(CO2) causes a {{c2::increase}} in hemoglobin affinity for O2. {{c1::70}}% of exhaled CO2 is in plasma as HCO3
Published	07/28/2024	{{c1::Increase}} in P(CO2) causes a {{c2::decrease}} in hemoglobin affinity for O2
Published	07/28/2024	fetal Gamma globin binds 2,3-DPG (same as 2,3, BPG) with {{c1::lower}} affinity than adult beta globin, so fetal Hb has {{c1::higher}} oxygen aff…
Published	07/28/2024	{{c2::Acute intermittent porphyria}} is a defect in heme biosynthesis that occurs at {{c1::PBG deaminase}} and causes {{c1::neurovisceral symptoms, ab…
Published	07/28/2024	Porphyria cutanea tarda is a defect in heme biosynthesis that occurs at {{c1::uroporphyrinogen decarboxylase}}, causes {{c1::blisters on sun-exposed a…
Published	07/28/2024	{{c2::Erythropoietic protoporphyria}} is a {{c1::non}} blistering disease caused by a defect in heme biosynthesis that occurs at {{c1::ferrochelatase}…
Published	07/28/2024	{{c1::Acute}} porphyria displays neurovisceral symptoms including abdominal pain and psychiatric/neurologic symptoms
Published	07/28/2024	Acute intermittent porphyria is an example of an {{c1::acute}} porphyria
Published	07/28/2024	{{c1::Cutaneous}} porphyria is characterized by photosensitivity
Published	07/28/2024	Porphyria cutanea tarda is an example of a {{c1::cutaneous}} porphyria
Published	07/28/2024	Erythropoietic protoporphyria is an example of a {{c1::cutaneous}} porphyria
Published	07/28/2024	In Porphyria cutanea tarda, sun exposure causes {{c1::blistering/scarring}}
Published	07/28/2024	Erythropoietic protoporphyria is characterized by {{c1::acute non-blistering photosensitvity}}
Published	07/28/2024	The {{c2::Embden Myerhoff}} glycolytic pathway in RBCs is aka {{c1::anaerobic glycolysis}}
Published	07/28/2024	{{c1::Pyruvate kinase deficiency}} results in congenital {{c1::non}}-spherocytic {{c2::hemolytic anemia}}. Hemolysis is {{c1::chronic}} and {{c2:…
Published	07/28/2024	{{c1::G6PD deficiency}} results from a defect in the hexose monophosphate shunt which prevents NADPH from being synthesized to reduce glutathione. {{c…
Published	07/28/2024	{{c1::G6PD deficiency}} is characterized by {{c1::Heinz}} bodies and {{c1::bite}} cell formations. It is an {{c1::X-linked::inheritance pattern}} diso…
Published	07/28/2024	{{c1::Methemoglobinemia}} is a disorder characterized by higher than normal levels of metHb
Published	07/28/2024	Methemoglobinemia is characterized by a {{c1::reduced}} ability for RBCs to bind O2, but {{c1::increased}} affinity for bound O2, thus causing a …
Published	07/28/2024	The major pathway for methemoglobin reduction is via {{c1::cytochrome b5 reductase}}, deficiency in this enzyme is one of the {{c1::hereditary}} …
Published	07/28/2024	The alternative method for methemoglobin reduction (Fe3+ to Fe2+) is via {{c1::NADPH methemoglobin reductase}}
Published	07/28/2024	A {{c1::low}} %O2 sat on a pulse oximeter with a {{c1::normal}} PO2 on arterial blood gas is a key symptom of {{c1::methemaglobinemia}}. Other sy…
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