Notes in 19 Hepatitis Virus

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Status	Last Update	Fields
Published	07/30/2024	Classic Signs of Hepatitis {{c1::Jaundice}} {{c2::Elevated Liver Enzymes (ALT/SGPT) }}
Published	07/30/2024	T/F Histopathologic lesions in the liver differ depending on each Hepatitis virus type{{c1::False}}
Published	07/30/2024	{{c1::Hepatitis A (HAV) }}Family{{c2::Picornaviridae }}Hepatitis Type {{c3::Infectious }}
Published	07/30/2024	{{c1::Hepatitis B (HBV) }}Family{{c2::Hepadnaviridae}} Hepatitis Type {{c3::Serum  }}
Published	07/30/2024	{{c1::Hepatitis C (HCV) }}Family{{c2::Flaviviridae}} Hepatitis Type {{c3::Post-transfusion }}
Published	07/30/2024	{{c1::Hepatitis D (HDV) }}Family{{c2::Unclassified }}Hepatitis Type {{c3::Defective Virus dependent on coinfection with HBV}}
Published	07/30/2024	{{c1::Hepatitis E (HEV) }}Family{{c2::Hepeviridae}} Hepatitis Type {{c3::Enterically transmitted hepatitis }}
Published	07/30/2024	Enveloped Hepatitis Viruses {{c1::HBV}}{{c1::HCV}}{{c1::HDV}}
Published	07/30/2024	Hep Virus that Does not have the ssRNA genome (dsDNA){{c1::HBV}}
Published	07/30/2024	Heat Stable, Acid Stable MOT is fecal-oral {{c1::HAV}}{{c1::HEV}}
Published	07/30/2024	Acid Sensitive MOT: sexual, parenteral {{c1::HBV}}{{c1::HCV}}{{c1::HDV}}
Published	07/30/2024	{{c2::HAV}}Incubation period: [{{c1::10 - (ave: 25-30) - 50}}]Often results from eating contaminated shellfish or other food and water Rarel…
Published	07/30/2024	T/F HAV has many serotypes {{c1::False}}
Published	07/30/2024	HAV Prevention  Heating food above {{c1::85°C}} for 1 minute and disinfecting with {{c1::Sodium 2Hypochlorite}} can inactivate HAV. …
Published	07/30/2024	HAV Epidemiology  Stool specimens may be infectious {{c2::2 weeks before up to 2 weeks}} after onset of jaundice Highest rates in childre…
Published	07/30/2024	Clinical Findings of HAV Signs and symptoms are due to immune-mediated damage to the {{c1::liver}}.  Abrupt onset (w/in {{c2::24}} hours)…
Published	07/30/2024	HAV Lab Diagnosis HAV/HAV RNA are detected in stool, blood, liver, and bile through (3): {{c1::Immunoassay }}{{c1::Nucleic Acid Hybridi…
Published	07/30/2024	HAV Lab Diagnosis Anti-HAV DetectionMethod of Choice: {{c1::ELISA }}
Published	07/30/2024	HAV{{c4::Anti-HAV IgM }}Appears during {{c3::acute}} phase Peaks {{c2::2}} weeks after elevation of liver enzymes Declines within {{c1::3-6}…
Published	07/30/2024	{{c1::Anti-HAV IgG }}Appears after {{c2::onset of disease}} and persists for {{c3::decades}}
Published	07/30/2024	Treatment, Prevention and Control  Hepatitis A vaccine is required for ALL Filipinos starting {{c1::one}} year old. There are 2 type…
Published	07/30/2024	Treatment, Prevention and Control There is no exact treatment for Hepatitis A Only {{c1::supportive intervention}}.
Published	07/30/2024	Treatment, Prevention and Control Immunoglobulins provides protection in {{c2::90%}} of cases when given within {{c1::2 weeks p…
Published	07/30/2024	Hep B  Median incubation period: [{{c1::50-(average of 60-90 days)-180 days}}] Establishes chronic infection and is a major factor of …
Published	07/30/2024	HBV Epidemiology  ●  {{c4::1 out of 10}} Filipinos is affected by Hepatitis B virus, which means in 100 persons there are 10 who are affe…
Published	07/30/2024	HBV Epidemiology  TRANSMISSION OF HEPATITIS B VIRUS AND SPECTRUM OF OUTCOMES OF INFECTION  Vertical and contact associated transmis…
Published	07/30/2024	HBV Epidemiology  TRANSMISSION OF HEPATITIS B VIRUS AND SPECTRUM OF OUTCOMES OF INFECTION  {{c1::Parenteral and sexual transmission…
Published	07/30/2024	HBV Clinical Findings  In the adult population, {{c1::65-80}}% of infections are inapparent and {{c2::90-95}}% recover completely ●  In …
Published	07/30/2024	HBV Clinical Syndromes Acute Infection  ● Only {{c1::25}}% of those infected are clinically apparent ● Characterized by {{c2::long incuba…
Published	07/30/2024	HBV Clinical Syndromes Chronic Infection ●  Occurs in {{c1::5-10%}} of HBV infections ({{c1::95}}% are neonates) ●  Usually occurs …
Published	07/30/2024	HBV Infection Clinical Syndrome Primary Hepatocellular Carcinoma (PHC)  ●  WHO: {{c1::80}}% of all PHC cases are secondary to c…
Published	07/30/2024	Window Period of Primary Hepatocellular Carcinoma (+/-)  ({{c1::-}}) HBsAg  ({{c2::-}}) anti-HBs, ({{c3::+}}) anti-HBc IgM  …
Published	07/30/2024	9c397e1fd0404be3bfb0a4c64f94b116-oa-1
Published	07/30/2024	9c397e1fd0404be3bfb0a4c64f94b116-oa-2
Published	07/30/2024	9c397e1fd0404be3bfb0a4c64f94b116-oa-3
Published	07/30/2024	9c397e1fd0404be3bfb0a4c64f94b116-oa-4
Published	07/30/2024	9c397e1fd0404be3bfb0a4c64f94b116-oa-5
Published	07/30/2024	9c397e1fd0404be3bfb0a4c64f94b116-oa-6
Published	07/30/2024	HBV Lab Diagnosis  Screening: {{c3::Agglutination}} Test ■ Negative screening test = {{c1::Negative for Hepatitis B}} ■ Positive screening te…
Published	07/30/2024	HBV Lab Diagnosis ● {{c3::Confirmatory}} tests:○  {{c1::ELISA (Ag & Ab detection)}}○  {{c2::PCR (for viral DNA) }}
Published	07/30/2024	HBV Treatment  First line therapies: ○  {{c1::Interferon alfa}} - 2a can lead to 25% loss of HBV DNA ○  {{c2::Entecavir}} - inhibi…
Published	07/30/2024	Current DOH Expanded Program of Immunization schedule.Hepatitis B is required at {{c1::birth}}. Then another 3 doses before the patient reach…
Published	07/30/2024	Hep C  Family: {{c6::Flaviviridae}}genus: {{c7::Hepacivirus}} Major agent for {{c2::non-A, non-B (NANB) hepatitis }} ●  Major …
Published	07/30/2024	HCVPost transfusion hepatitis occurs in {{c1::5-10}}% of transfusion recipients
Published	07/30/2024	HCV Salient Features  Incubation period: {{c1::[15 - (ave. 50 days) - 160 days] }}● Principal age distribution is {{c2::adults}} ● R…
Published	07/30/2024	HCV Clinical Syndromes  ● Acute Form ○ Similar to acute hepatitis A and B but {{c1:: less inflammatory response and milder symptoms (e.g. mild…
Published	07/30/2024	HCV Lab Diagnosis  ●  {{c2::ELISA (antibody detection)}} ●  {{c2::RT-PCR ( detects HCV-RNA)}} ●  {{c2::Serologic markers}} ○…
Published	07/30/2024	Standard Treatment of HCV {{c1::Interferon Alpha}} {{c2::Ribavirin }}
Published	07/30/2024	HDV ○  Surrounded by the {{c1:: Hepatitis B surface antigen (HBsAg) }} envelope ○  {{c2::HDAg}} is the only protein coded for by HDV RNA …
Published	07/30/2024	Smallest of known human pathogens responsible for ~{{c2::40}}% of fulminant hepatitis{{c1::HDV: ssRNA }}
Published	07/30/2024	HDV is often associated with the {{c1::most severe forms of hepatitis in HBsAg positive patients }}.
Published	07/30/2024	HDV is classified in the {{c1::Deltavirus}} genus.
Published	07/30/2024	HDV can replicate only in {{c1::HBV-infected cells}}.
Published	07/30/2024	HDV Epidemiology  HDV does NOT appear to be a {{c1::sexually transmitted disease }} Incubation period: {{c2::2-12 weeks }}…
Published	07/30/2024	HDV Clinical Syndromes  Delta agent carriers: are more likely to develop {{c1::fulminant hepatitis }} HBV-HDV coinfection ○  The…
Published	07/30/2024	HDV Clinical Syndromes Acute HDV superinfection○  There is still the presence of {{c4::hepatitis B antigen}}○  However, during the time…
Published	07/30/2024	HDV Clinical Syndromes Chronic HDV superinfection○ There is the {{c2::appearance of HBsAg all throughout}} and {{c1::HDAg doesn’t go down bu…
Published	07/30/2024	HDV Lab Diagnosis  ●  {{c1::Enzyme-Linked Immunosorbent Assay (ELISA) & Radioimmunoassay (RIA)}} – for antigen and antibody detection…
Published	07/30/2024	HDV Treatment, Prevention, Control  Treatment: {{c1::Non known }}●  {{c2::Hepatitis B vaccine can be protective for Delta infection}}○ Si…
Published	07/30/2024	HepE Course: {{c4::Very similar to hepatitis A}} ○ Causes {{c5::only acute disease}} ○ Most of the time there is {{c6::no chronicity}}● …
Status	Last Update	Fields