Notes in 01_Leukaemia

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Published	02/10/2024	Diseases under Myeloid Malignancy {{c1::Acute Myeloid Leukaemia (AML)}} {{c1::Chronic Myeloid Leukaemia (CML)}} {{c1::Myelodysplastic Syndromes (MDS)}…
Published	02/10/2024	Diseases under Lymphoproliferative Disorders {{c1::Non-Hodgkin Lymphoma (NHL)}} {{c1::Chronic Lymphocytic Leukaemia (CLL)}} {{c1::Hodgkin Lymphoma (HL…
Published	02/10/2024	{{c1::Leukaemia}} is {{c2::broad term, applied to a range of blood or bone marrow cancers classified as acute or chronic and subclassified as myeloid …
Published	02/10/2024	{{c1::Acute}} Leukaemias involve {{c2::failure of cell maturation and differentiation, leading to a build-up of useless immature cells in the bone mar…
Published	02/10/2024	{{c1::Chronic}} Leukaemias involve {{c2::cell maturation and differentiation, leading to a build-up overtime of differentiated mature cells and immatu…
Published	02/10/2024	{{c1::Myeloproliferative disorders}} involve an {{c2::overproduction of myeloid cells, either mature or immature i.e. blasts, leading to a build up of…
Published	02/10/2024	{{c1::Lymphoproliferative disorders}} involve an {{c2::overproduction of lymphoid cells, either immature or mature i.e. B-lymphoblasts, or of blood/bo…
Published	02/10/2024	Classifications of Acute Leukaemia{{c1::Acute Lymphoblastic Leukaemia (ALL)}}{{c1::Acute Myeloid Leukaemia (AML)}}
Published	02/10/2024	Classifications of Chronic Leukaemia{{c1::Chronic Lymphocytic Leukaemia (CLL)}}{{c1::Chronic Myeloid Leukaemia (CML)}}
Published	02/10/2024	Presentation of {{c2::Acute Myeloid Leukaemia (AML)}}{{c1::Triad of Bone marrow failureAnaemia (fatigue)Thrombocytopenic bleeding (Purpura and Mucosal…
Published	02/10/2024	Presentation of {{c2::Chronic Myeloid Leukaemia (CML)}} {{c1::Anaemia}} {{c1::Massive Splenomegaly}} {{c1::Weight loss}} {{c1::Hyperleukostasis (Funda…
Published	02/10/2024	Presentation of {{c2::Acute Lymphoblastic Leukaemia (ALL)}} {{c1::Onset: Childhood < 6 years (75% of cases)}} {{c1::Bone marrow failure (anaem…
Published	02/10/2024	Presentation of {{c2::Chronic Lymphocytic Leukaemia (CLL)}} {{c1::Often asymptomatic}} {{c1::Most common adult leukaemia}}{{c1::Bone marrow failure (a…
Published	02/10/2024	Investigations of {{c2::Acute Myeloid Leukaemia (AML)}} {{c1::Full Blood Count (shows Cytopenias: Anaemia, Thrombocytopenia, Neutropenia)}}{{c1::Blood…
Published	02/10/2024	Diagnosis of {{c2::Acute Myeloid (AML)}} Leukaemia is via {{c1::Bone marrow aspirate showing Myeloid Blast cells >20%}}
Published	02/10/2024	Investigations of {{c2::Chronic Myeloid Leukaemia (CML)}} {{c1::Full Blood Count: Anaemia, Thrombocythemia (High levels of platelets), and Hyperleukoc…
Published	02/10/2024	Diagnostic Marker of {{c2::Chronic Myeloid (CML)}} Leukaemia is {{c1::Bone marrow aspirate showing Philadelphia Chromosome t(9;22)…
Published	02/10/2024	Investigations of {{c2::Acute Lymphoblastic Leukaemia (ALL)}} {{c1::Full Blood Count (Anaemia, Thrombocytopenia, Leukocytosis)}}{{c1::Blood Film (show…
Published	02/10/2024	Investigations of {{c2::Chronic Lymphocytic Leukaemia (CLL)}} {{c1::Full Blood Count (Anaemia and Thrombocytopaenia)}}{{c1::Blood Film (Mature lymphoc…
Published	02/10/2024	The only Leukaemia that presents with {{c1::Thrombocythaemia (High platelets)}} is {{c2::Chronic Myeloid Leukaemia (CML)}}
Published	02/10/2024	Treatment of Acute Myeloid Leukaemia (AML)[1] {{c1::Supportive Care (Crucial)}}[2] {{c1::Anti-Leukaemic Chemotherapy}}
Published	02/10/2024	Treatment of Chronic Myeloid Leukaemia (CML) {{c1::Tyrosine Kinase Inhibitors of BCR-ABL e.g. Imatinib, Dasatinib}} {{c1::If TKI fails: Allogeneic Tra…
Published	02/10/2024	Treatment of Acute Lymphoblastic Leukaemia (ALL) {{c1::Induction Chemotherapy for Remission}}{{c1::CNS directed treatment}}{{c1::Stem cell transplanta…
Published	02/10/2024	Treatment of Chronic Lymphocytic Leukaemia (CLL) {{c1::Often ‘’watch and wait’’}} {{c1::Cytotoxic chemotherapy (e.g. fludarabine, bendamustine)}} {{c1…
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