Notes in VI. Drugs for Angina and Arrhythmia

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Published	10/21/2024	MECHANISM OF VASODILATORS IN REDUCING OXYGEN DEMANDIn the cGMP Pathway, {{c1::Vasodilators}} like nitrates increase {{c2::cGMP}}, leading to the depho…
Published	10/21/2024	Pharmacodynamics of Drugs acting on Vascular Smooth muscle{{c1::Calcium Channel Blockers}} block calcium entry into smooth muscle, reducing contractio…
Published	10/21/2024	Integrated Approach to Managing Angina{{c1::Combination Therapy}} involves how multiple drug classes work together to reduce {{c2::oxygen demand}} and…
Published	10/21/2024	Overview of Drugs to treat AnginaThe primary drug groups for treating angina are {{c1::organic nitrates}}, {{c1::calcium channel blockers}}, and {{c1:…
Published	10/21/2024	NITRATES AND NITRITES: CHEMISTRY ANDPHARMACODYNAMICS{{c1::Organic nitrates}} such as {{c2::nitroglycerin}} have been used for over 160 years in cardio…
Published	10/21/2024	NITRATES AND NITRITES: CHEMISTRY ANDPHARMACODYNAMICSDue to the {{c1::first-pass effect}}, nitroglycerin has low {{c2::oral bioavailability}} because o…
Published	10/21/2024	Vascular Effects:→ {{c1::Venous dilation}} increases {{c3::venous capacitance}}, reducing {{c1::preload}}.→ {{c2::Arterial dilation}} affects large ar…
Published	10/21/2024	Integration of Therapy:→ The combination of drugs tailored to patient needs:▪ {{c1::Nitrates}}▪ {{c1::Calcium Channel Blockers}}▪ {{c1::Beta-Blockers}…
Published	10/21/2024	PDE-5 Inhibitors:→ {{c1::Sildenafil}}→ {{c1::Tadalafil}}→ {{c1::Vardenafil}}→ {{c1::Avanafil}}These drugs increase {{c2::GMP levels}} by inhibiting it…
Published	10/21/2024	Clinical Use of PDE-5 Inhibitors:→ {{c1::Erectile Dysfunction}}: Effective in men with intact {{c2::innervation}} and sufficient {{c2::parasympathetic…
Published	10/21/2024	PDE-5 Inhibitors Precautions:→ Interaction with {{c1::nitrates}}: Concomitant use can cause severe {{c2::hypotension}} and is contraindicated.→ {{c2::…
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