Notes in Drug Treatment For Ischaemic Heart Disease LECTURE 37

To Subscribe, use this Key

Status	Last Update	Fields
Published	01/07/2025	digoxin mechanism of actioninhibits {{c1::Na+/K+ ATPase}} (sodium pump)binds to extracellular {{c1::K+ }} binding siteincreases {{c1::i…
Published	01/07/2025	unlike most HF medications, digoxin {{c1::doesn't decrease blood pressure}}
Published	01/07/2025	true or false: digoxin hase a narrow therapeutic window{{c1::TRUE}}
Published	01/07/2025	what is digoxin used for?end-stage {{c1::heart failure}}to slow heart rate in {{c1::atrial fibrillation}}
Published	01/07/2025	digoxin antidote: {{c1::digibind}}
Published	01/07/2025	digoxin side effects{{c1::arrythmias}}
Published	01/07/2025	use of loop diuretics: powerful diuretics which treat {{c1::oedema (peripheral & pulmonary)}}
Published	01/07/2025	loop diuretic core drug: {{c1::furosemide}}acts on: {{c1::thick ascending limb of loop of Henle}}blocks: {{c1::Na+/K+/2Cl- cotransporte…
Published	01/07/2025	furosemide m.o.ablocks {{c1::Na/K/Cl}} cotransporter in {{c1::thick ascending limb}} of {{c1::loop of Henle}as a result:increased loss of {{…
Published	01/07/2025	haemodynamic effects of ACE inhibitorsarteriolar {{c1::dilation}} = decreased {{c1::afterload}}{{c1::venodilation}} = decrease in {{c1::prel…
Published	01/07/2025	ACE inhibitor m.o.ablock conversion of {{c1::angiotensin I to angiotensin II}}ACE breaks down {{c1::Bradykinin (a vasoactive peptide)}}so ACE-I increa…
Published	01/07/2025	ACE inhibitor core drug: {{c1::ramipril}}
Published	01/07/2025	ACE inhibitors side effects{{c1::dry cough}} due to bradykinin accumulation in lungs{{c1::renal}} impairment{{c1::hyperkalaemia}} - com…
Published	01/07/2025	angiotensin II receptor antagonists (ARBs) m.o.ablock action of {{c1::AT-II on AT1 receptor}}Advantage over ACE-Inhibitors?doesn't cause {{c1::dr…
Published	01/07/2025	AR(II)B most commonly used for heart failure: {{c1::candesartan}} (losartan is also on core drug list)
Published	01/07/2025	aldosterone antagonists m.o.ablock upregulation of {{c1::Na channel in DCT by aldosterone}}prognostic benefit in: poor {{c1::LV}} function and po…
Published	01/07/2025	aldosterone antagonist core drug for heart failure: {{c1::spironolactone}}
Published	01/07/2025	spironolactone side effects{{c1::impaired renal function}}{{c1::hyperkalaemia}}{{c1::gynaecomastia (similar to oestrogen)}}
Published	01/07/2025	*!positive inotropes (e.g. digoxin) uniformly associated with {{c1::}}they cause:{{c1::malignant}} arrythmias{{c1::catecholamine}} card…
Published	01/07/2025	beta 1 receptor effects:{{c1::}}{{c1::}}{{c1::}}
Published	01/07/2025	What are the effects of B-blockers for chronic HF?slow {{c1::heart rate}} - increased diastolic filling timereduce {{c1::afterload}} (lower …
Published	01/07/2025	*!why can beta blockers be used in chronic HF but not acute HF?because they do not affect {{c1::contractility}} in the absence of catecholaminesc…
Published	01/07/2025	effects of beta blockershearteffect: {{c1::decrease force and rate of contraction and BP}}side effects: {{c1::fatigue, bradycardia}}lungs (B2)eff…
Published	01/07/2025	beta blockers in HFmust be {{c1::B1}} receptor selective{{c1::bisoprolol}} (most common){{c1::carvedilol}} (strong clinical trial evide…
Published	01/07/2025	angina - principles of treatmentreduce {{c1::O2}} demand:reduce {{c1::contractile}} force/rateslow {{c1::cardiac}} metabolismreduce {{c…
Published	01/07/2025	drugs for angina:{{c1::beta blockers}}{{c1::calcium channel blockers}}{{c1::nitrates}}
Published	01/07/2025	anginal nitrates:short acting: {{c1::Glyceryl trinitrate (GTN) spray}}for {{c1::angina}} attacks{{c1::prophylaxis}} (before exercise)slow re…
Published	01/07/2025	nitrates effectNO to tissues = vaso{{c1::dilation}} (+coronary artery dilation)reduces {{c1::preload and afterload}} = reduces cardiac workl…
Published	01/07/2025	nitrates m.o.aNO activates {{c1::Guanylyl cyclase}}increases {{c1::cGMP}}inhibits {{c1::myosin light chain kinase}}decreased {{c1::myosin ph…
Published	01/07/2025	nitrates side effectsvasodilation = {{c1::headaches, hypotension, dizziness, syncope}}{{c1::nitrate tolerance}}: rapid loss of effect with continuous …
Published	01/07/2025	calcium channel blocker m.o.ablock {{c1::L-type voltage-gated Ca2+ }}channelsdecrease intracellular {{c1::Ca2+}}= arteriole {{c1::SM relaxation}}…
Published	01/07/2025	side effects of calcium channel blockersa{{c1::nkle swelling}}p{{c1::alipitations}} - reflex tachycardia (A)c{{c1::onstipation}}f{{c1::lushing/he…
Published	01/07/2025	dihydopyridine Ca2+ channel blockers: {{c1::amlodipine}}non- dihydopyridine Ca2+ channel blockers: {{c1::diltiazem & verapamil}}
Published	01/07/2025	angina other drugs (not on core drug list but used clinically){{c1::}}
Published	01/07/2025	heart failure: drug combinations - 6.5{{c1::}}
Published	01/07/2025	secondary prevention of IHDantiplatelet: {{c1::aspirin/clopidogrel}} (sometimes together after stent because stents are very thrombogenic)AC…
Published	01/07/2025	Outline the drug that belongs to the ARIIB group that is most commonly used for Heart failure.
Published	01/07/2025	diuretics (e.g. furosemide) side effects
Status	Last Update	Fields