Notes in Molecular Mechanisms of Action Potential Generation

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Status	Last Update	Fields
Published	09/07/2023	Changes in {{c1::K+}} and {{c1::Na+}} permeability underlie the action potential.
Published	09/07/2023	At resting potential, PK {{c1::>>}} PNa.
Published	09/07/2023	After crossing threshold, PNa {{c1::increases}}.
Published	09/07/2023	At the peak of the action potentail, PNa {{c1::>>}} PK.
Published	09/07/2023	During repolarization, PNa {{c1::decreases}}.
Published	09/07/2023	Membrane permeability is dependent on {{c1::Vm}}.
Published	09/07/2023	Before a Na+ channel closes, it becomes {{c1::inactivated}}.
Published	09/07/2023	Before a Na+ channel closes, it becomes {{c1::inactivated}}.
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Published	09/07/2023	Unline K+ channels, Na+ channels have an {{c1::inactivation gate}}.
Published	09/07/2023	During inactivation, the Na+ ion channel pore is still {{c1::open}}.
Published	09/07/2023	Inactivation of Na+ channels is relieved by {{c1::repolarization.}}
Published	09/07/2023	The absolute refractory period is defined by the {{c1::inactivation period}} of Na+ channels.
Published	09/07/2023	The {{c1::relative refractory}} period is when Na+ channels have reactivated/closed but K+ channels are still open.
Published	09/07/2023	A Na+ channel is composed of {{c1::four::number}} motifs, each with {{c2::six::number}} transmembrane segments.
Published	09/07/2023	There are {{c1::many}} genes that encode K+ channels. We know of at least {{c1::ten}} genes that encode Na+ channels.
Published	09/07/2023	The yellow transmembrane proteins in these channels are responsible for the channels' {{c1::voltage sensitivity.}}
Published	09/07/2023	The voltage sensative {{c1::"wings"}} of channels allow them to open and close based on the charge {{c2::inside}} the cell.
Published	09/07/2023	Three examples of pumps found in the nervous system are: {{c1::ATPase pumps, Ion exchanges, and Co-transporters.}}
Published	09/07/2023	Sodium-Potassium ATPase is energy-{{c1::dependent}}.
Published	09/07/2023	The steps of Sodium-Potassium ATPase exchanging ions is:1. {{c1::Na+ binding}}2. {{c2::Phosporylation using ATP}}3. {{c3::Conformational change causin…
Published	09/07/2023	Sodium-Potassium ATPase uses the following ratio: {{c1::3::number}} {{c1::Na+::ion}} out, {{c1::2:number}} {{c1::K+::ion}} in
Published	09/07/2023	Sodium-Phosphate ATPase lets out more positive charge than it lets in. There, it is {{c1::electrogenic}}.
Status	Last Update	Fields