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L09 Substances of Abuse Part 1
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wisconsin-lion-harry-fifteen-golf-south
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Last Update
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Published
06/22/2023
What is this? {{c1::Opium}}
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06/22/2023
We find several chemical in Opium? The two big chemicals are {{c1::morphine}} and {{c1::codeine}}We also find- Potavarin: {{c2::smooth muscle rel…
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06/22/2023
Heroin is a brand name for the chemical {{c1::diacetyl morphine.}}
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06/22/2023
What are the 3 inextricable, overlapping, concurrent crisis of opiod consequences? 1. {{c1::Chronic Pain}}  …
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06/22/2023
Where are the highest rates of deaths in our society? {{c1::Opiod}} Poisining
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What are the Consequences of Opiod Use?{{c2::AbuseTolerance DependenceHyperAlgesiaAddiction}}These all can lead to {{c1::Overdose/Death }}
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Consequences of Opiod use:Abuse: {{c1::Use for the feeling}}
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Consequences of Opiod use:Tolerance: {{c1::Need for more opioid}}
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Consequences of Opiod use:Dependence: {{c1::Withdrawal upon cessation}}
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Consequences of Opiod use:Hyperalgesia: {{c1::Heightened Sensitivity to Pain}}
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Consequences of Opiod use:Addiction: {{c1::Compulsive use despite harm}}
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What are the differences between HyperAlgesia and Tolerance?Hyperalgesia is {{c1::heightened sensitivity to pain}} while tolerance is {{c1::need…
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How many people does Chronic Pain affect? It affects 116 million people in the US. Pain is the {{c1::5th Vital Sign}} (Joint Commision) and …
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The US accounts for 4% of the world’s population but uses {{c1::80%}} of its prescription opioid”
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These are all examples of what? {{c1::Prescription opioids}}
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WHat are the 3 big signs of someone experiencing an Opiod overdose?{{c1::Respitory Depression Miosis Lethargy}}
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What is the Newest Opium War? It is about how {{c1::potent}} drugs have become!Heroin is about twice as {{c1::potent}} as morphine. The Potency o…
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Dont confuse potency with {{c1::concentration}} when it comes to drugs
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Which concepts affect impact of the drug?{{c1::Dose Potency Dose Rate Lipophilicity}}
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Which Drug is more potent based on these curves?{{c1::Drug A}} since it has a faster effect on the dose response curve
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WHat is the significance of the Dose Rate of OxyContin?Oxycontin are not supposed to be broken, chewed or crushed because it would lead to {{c1:…
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{{c3::Lipophilicity}} allows drugs to pass the blood-brain barrier If you take morphine and add acetyl groups, you get an {{c2::opioid}}
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21. What paper is the world of addiction built on? {{c1::Porter and Jick }}
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Opioid Antagonism:Death from opioids: {{c1::ventilatory depression }}{{c2::Naloxone}} provides effective competitive antagonism{{c3::Re…
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Buprenorphine is a {{c1::partial}} agonist,
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Naloxone is a {{c1::full}} antagonist that produces withdrawal
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06/22/2023
What are the two types of Ethanol Products?{{c1::Fermented}} and {{c1::Distilled}}
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06/22/2023
Fermented {{c1::• Beer • Malt liquor • Wine • Cider • Sake }}
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What examples of alcohol are below? {{c1::Distilled }} • Whisky/Bourbon/Scotch• Vodka • Everclear (grain alcohol) • Rum • Tequila • Br…
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06/22/2023
What is a Standard Drink? Proof = {{c1::2 x % concentration}} (in the US) An ounce = {{c2::30 mL}} (close enough) Standard drink has {{c3…
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What is the triphasic dose response?If you drink far too much you could stop {{c1::breathing.}}
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What is the "Legal Limit"? • October 2000: Federal legal intoxication standard of {{c1::80 mg/dL (actually 80 BU)}} • Per Se [in and of itself] …
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06/22/2023
What are things that impact your BAC? • {{c1::Number}} of drinks • {{c2::Rate}} of consumption • What is {{c3::drank}} • {{c4::Food}} • {{c5:…
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06/22/2023
What are Clinical Effects of Ethanol? Triphasic dose-response effect• {{c1::Absorptive (induction)}} phase • Par…
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06/22/2023
How does alcohol (ehtnaol) impact the CNS? Changes {{c1::“fluid” properties of lipid membranes}} • Haldane effect Inhibits proper function {{…
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PHARMACOKINETIC TOLERANCE A consequence of {{c1::increased metabolism}} after a drug is repeatedly administered Results in {{c2::less drug…
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PHARMACODYNAMIC TOLERANCE • {{c1::Down-regulation}} of receptors (higher drug concentration needed) &…
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06/22/2023
What is ACUTE TOLERANCE TACHYPHYLAXIS "THE MELLANBY EFFECT" ? Effects of a given BAC on the descending limb of the time- concentration curve (elimi…
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What is the below chart indicative of? {{c1::ALcohol Withdrawal}}
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06/22/2023
When you stop drinking you develop a predictable series of effects that we call withdrawal. Early on {{c3::tremulousness, tachycardia, nausea, di…
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06/22/2023
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06/22/2023
Hangovers depend on what levels in alcohol?Hangovers depend on {{c1::Congener}} Levels in Different types of alcohol.
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06/22/2023
Disulfiram-like reaction "Asian flush" Findings Intense flushing Pronounced {{c1::hemodynamic effects}} Subjective perception of gene…
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06/22/2023
What is Flunitrazapam?It is also known as {{c1::roofies}} and its a {{c1::date rape drug}}
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06/22/2023
Y-Hydroxybutyrate and Analogs Similar clinical effects to {{c2::benzodiazepines }} • Euphoria • Deep {{c1…
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06/22/2023
What is the list below all examples of? {{c1::Historical sedative hypnotics}}They are:{{c2::• Barbiturates • Bromides • Chloral hydrate • Me…
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06/22/2023
What occurs with Sedative Intoxication? • Coma with {{c1::normal vital signs}} for most • Supportive care • Antidote …
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