Notes in PHAR117 Li L03

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Status	Last Update	Fields
Published	10/04/2023	DiffusionThe {{c1::transfer of mass}} from {{c1::one region to another region}}Result of {{c2::random molecular motions.}}From {{c3::high concentratio…
Published	10/04/2023	Ink in Water ExampleDrop Ink in waterMixture becomes {{c1::heterogenous (water and ink are separate)}}Over time, mixture becomes {{c2::homogenous}} be…
Published	10/04/2023	Defining DiffusionDiffusion: a process involved {{c1::migration of molecules}}.Diffusant: the {{c2::molecules that migrate in diffusion process}} (als…
Published	10/04/2023	Fick's First LawConcentration {{c1::decreases}} as distance {{c1::increases}}
Published	10/04/2023	Fick's First Law{{c1::Flux}} is proportional to the {{c1::concentration gradient.}}
Published	10/04/2023	Flux (J){{c1::Amount of drug}} (M) {{c1::diffuses through a barrier}} with a cross section area of S {{c1::in a given time.}}Unit of fluxg/sec x cm2Am…
Published	10/04/2023	DiffusivityAlso called diffusion {{c1::constant}}, diffusion {{c1::coefficient}}.Unitcm2/sec{{c2::Temperature}} dependent{{c2::Diffusion barrier}} dep…
Published	10/04/2023	Diffusion BarriersAnything that will {{c1::slow down the diffusion process}} can be considered as a diffusion barrier.The barriers can be in {{c2::liq…
Published	10/04/2023	Diffusion will go from {{c1::high concentration}} to {{c1::low concentration}} even with a diffusion barrier present (obvious)
Published	10/04/2023	Pay attention buddyC: conc. of diffusant in the solution {{c1::adjacent to the diffusional barrier}} C’: concentration of diffusant {{c2::in the diffu…
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Published	10/04/2023
Published	10/04/2023	Biopharmaceutics Classification System (BCS)Class I substances {{c1::high}} solubility and {{c1::high}} permeabilitywill dissolve {{c2::well…
Published	10/04/2023	Biopharmaceutics Classification System (BCS)Class II substances{{c1::low}} solubility and {{c1::high}} permeability{{c2::will not dissolve well}} but …
Published	10/04/2023	Biopharmaceutics Classification System (BCS)Class III substances{{c1::high}} solubility and {{c1::low}} permeabilitywill dissolve {{c2::well}} but {{c…
Published	10/04/2023	Biopharmaceutics Classification System (BCS)Class IV substances{{c1::low}} solubility and {{c1::low}} permeability{{c2::will not dissolve}} well {{c2:…
Published	10/04/2023	According to the Biopharmaceutics Classification System...Highly Soluble Drug Substance is defined as  Highest dose unit {{c1::dissolves}} in ini…
Published	10/04/2023	Greaseballs are an example of a {{c1::Class II substance}} whereas Brick Dust is an example of a {{c1::Class IV substance}} in the BCS system
Published	10/04/2023	Most drugs are in {{c1::Classes I or II}} in the BCS system
Published	10/04/2023	Membrane PermeationGeneral Rule: As time {{c1::increases}}, {{c1::amount permeated}} increases
Published	10/04/2023	Lag Timerefers to the rate of permeation at the {{c1::non-steady state}}is not {{c1::a constant rate}} of permeation
Published	10/04/2023	Diffusion under Sink Condition at Steady StateSteady Stateno {{c2::net change for a system in a given period}}in this case, the amount of moleculesocc…
Published	10/04/2023	Cumulative Permeation EquationThis equation states:1. the {{c1::amount of drug}} is equivalent to the ({{c1::diffusivity}} x the {{c1::surface area}} …
Published	10/04/2023	Trancellular and Paracellular TransportTranscellular Transport (Straight Blue Line){{c1::Lipoidal}} pathwayAcross {{c1::bilayer and intercellular lipi…
Published	10/04/2023	Application of Diffusion Theory in Pharmaceutical SciencesDrug transport across biological membranesDrug {{c1::absorption}} – across a barrierDrug {{c…
Published	10/04/2023	Drug Release KineticsZero Order release is {{c1::preferred}}drug releases at {{c1::constant rate over time}}Diffusion-Controlled Drug Release (Square …
Published	10/04/2023	Zero Order Drug Delivery Based on Diffusion (good luck we barely went over this imma kms)
Status	Last Update	Fields