Notes in 12SulfonamidesTrimethoprimFluoroquinolones

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Status	Last Update	Fields
Published	07/30/2024	Folate production in bacteriap-Aminobenzoic acid → {{c1::Dihydropteroate synthase}} → {{c2::Dihydrofolic acid}}Dihydrofolic acid → {{c1::Dih…
Published	07/30/2024	Sulfonamides MOA: {{c1::Competitive inhibition with PABA for Dihydropteroate synthase}}
Published	07/30/2024	Trimethoprim MOA: {{c1::Inhibition with PABA for Dihydrofolate reductase}}
Published	07/30/2024	Sulfonamides are prepared as {{c1::sodium salts}} used for IV administration
Published	07/30/2024	Sulfonamies are more soluble in {{c1::alkaline}} pH
Published	07/30/2024	QC Bactericidal 1. Sulfonamides 2. TMP-SMXA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC Sulfonamide activity against 1. Aerobes 2. AnaerobesA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	QC Sulfonamide activity against 1. Gram (+) 2. Gram (-)A. 1>2B. 1<2C. 1=2Answer: {{c1::C}}
Published	07/30/2024	VR 1. PABA 2. Sulfonamide resistanceA. Increase in 1, increase in 2B. Increase in 1, decrease in 2C. Increase in 1 has no effect on 2Answer: {{c1::A}}
Published	07/30/2024	QC Sulfonamides for skin infections 1. Oral, absorbable 2. Oral, non absorbableA. 1>2B. 1<2C. 1=2Answer: {{c1::C}}
Published	07/30/2024	QC Sulfonamides for patients with GI problems 1. Oral, absorbable 2. Oral, non absorbableA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC Sulfonamides for patients with UTI1. Oral, absorbable 2. Oral, non absorbableA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	QC Sulfonamide metabolism in the liver 1. Acetylation 2. GlucuronidationA. 1>2B. 1<2C. 1=2Answer: {{c1::C}}
Published	07/30/2024	QC After sulfonamide metabolism in the liver 1. Active form 2. Inactive formA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	{{c1::Sulfadiazine w/ Pyrimethamine::sulfonamide}} is the first-line therapy for treatment of acute toxoplasmosis
Published	07/30/2024	{{c1::Sulfadoxine w/ Pyrimethamine::sulfonamide}} is the second-line treatment for malaria
Published	07/30/2024	{{c1::Sulfasalazine::sulfonamide}} is for ulcerative colitis and enteritis
Published	07/30/2024	{{c1::Sodium Sulfacetamide::sulfonamide}} is for conjunctivitis and adjuct therapy for trachomoa
Published	07/30/2024	{{c1::Mafenide Acetate::sulfonamide}} is for burns but it may cause metabolic {{c2::acid}}osis
Published	07/30/2024	Sulfonamides are contraindicated in patients with {{c1::G6PD deficiency}}
Published	07/30/2024	[QC] Toxicity 1. Mafenide Acetate 2. Silver Sulfadiazine{{c1::A}}
Published	07/30/2024	{{c1::Sulfur Sulfadiazine}} is the preferred sulfonamide for prevention of infection of burn wounds because it is less toxic
Published	07/30/2024	Arrange in descending order according to duration of activity: Sulfamethoxazole, Sulfadoxine, Sulfisoxazole{{c1::Sulfadoxine, Sulfamethoxazole, S…
Published	07/30/2024	Sulfonamide ADRs: {{c1::Exfoliative dermatitis, Steven-Johnson syndrome, Hematuria, Crystalluria}}
Published	07/30/2024	The most soluble sulfonamide is {{c1::sulfisoxazole}}
Published	07/30/2024	Can sulfonamides and Trimethoprim penetrate the CNS?{{c1::Y::Y/N}}
Published	07/30/2024	VR 1. Dihydrofolate reductase 2. Trimethoprim effectA. Increase in 1, increase in 2B. Increase in 1, decrease in 2C. Increase in 1 has no effect on 2A…
Published	07/30/2024	Trimethoprim concentrates in {{c1::Vaginal fluid and Prostatic fluid}}
Published	07/30/2024	QC Lipid solubility 1. Sulfamethoxazole 2. TrimethoprimA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC Volume of distribution 1. Sulfamethoxazole 2. TrimethoprimA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC Ratio in their formulation (TMP-SMX) 1. Sulfamethoxazole 2. TrimethoprimA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	QC High dose for P. jiroveci pneumonia 1. IV TMP-SMX 2. Oral TMP-SMXA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC For pneumocystis pneumonia 1. IV TMP-SMX 2. Oral TMP-SMXA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	QC For acute UTI 1. IV TMP-SMX 2. Oral TMP-SMXA. 1>2B. 1<2C. 1=2Answer: {{c1::C}}
Published	07/30/2024	VR 1. Trimethoprim 2. WBC amountA. Increase in 1, increase in 2B. Increase in 1, decrease in 2C. Increase in 1 has no effect on 2Answer: {{c1::B}}
Published	07/30/2024	VR 1. Trimethoprim 2. Creatinine secretionA. Increase in 1, increase in 2B. Increase in 1, decrease in 2C. Increase in 1 has no effect on 2Answer: {{c…
Published	07/30/2024	Fluoroquinolones are synthetic fluorinated analogs of {{c1::nalidixic acid}}
Published	07/30/2024	Fluoroquinolones MOA: {{c1::Block bacterial DNA synthesis by inhibiting bacterial topoisomerase II (DNA gyrase) and topoisomerase IV}}
Published	07/30/2024	QC Fluoroquinolone action on 1. Topoisomerase II 2. Topoisomerase IIIA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	QC Prevents the relaxation of positively supercoiled DNA 1. Topoisomerase IV 2. Topoisomerase IIA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC Interferes with separation of replicated chromosomal DNA 1. Topoisomerase IV 2. Topoisomerase IIA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	All generations of fluoroquinolones have, relatively, the same gram ({{c1::-}}) coverage, but increasing gram ({{c1::+}}) coverage in the next generat…
Published	07/30/2024	These fluoroquinolones are used as prophylaxis of bacterial infection in neutropenic cancer patients: {{c1::Ciprofloxacin, levofloxacin, or moxif…
Published	07/30/2024	{{c1::Norfloxacin}} is the least active fluoroquinolone
Published	07/30/2024	{{c1::Ciprofloxacin}} is the MOST ACTIVE FLUOROQUINOLONE AGAINST GRAM (-)
Published	07/30/2024	QC Activity against P. aeruginosa 1. Levofloxacin 2. CiprofloxacinA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC Activity against S. pneumoniae 1. Levofloxacin 2. CiprofloxacinA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	QC L-isomer of ofloxacin 1. Levofloxacin 2. CiprofloxacinA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	QC Activity against MRSA 1. Ofloxacin 2. PerfloxacinA. 1>2B. 1<2C. 1=2Answer: {{c1::C}}
Published	07/30/2024	Multiple ChoiceChoose which of the following does not belong to the groupA. PerfloxacinB. CiprofloxacinC. OfloxacinD. LevofloxacinAnswer: {{c1::A}}
Published	07/30/2024	Multiple ChoiceChoose which of the following does not belong to the groupA. MoxifloxacinB. GemifloxacinC. OfloxacinD. GatifloxacinAnswer: {{c1::C}}
Published	07/30/2024	QC Gram (-) activity 1. Ciprofloxacin 2. 3rd Gen FluoroquinolonesA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
Published	07/30/2024	Respiratory quinolones are {{c1::Levofloxacin, gemifloxacin, and moxifloxacin}}
Published	07/30/2024	The most toxic 3rd Gen fluoroquinolone is {{c1::Gatifloxacin}}
Published	07/30/2024	{{c1::True::True or False}}Cross resistance exists in fluoroquinolones.
Published	07/30/2024	QC Fluoroquinolones route of administration 1. IV 2. OralA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC Half life 1. Ciprofloxacin 2. LevofloxacinA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC Effect on fluoroquinolone absorption 1. Divalent cation 2. Trivalent cationA. 1>2B. 1<2C. 1=2Answer: {{c1::C}}
Published	07/30/2024	VR 1. Antacid 2. Fluoroquinolone absorptionA. Increase in 1, increase in 2B. Increase in 1, decrease in 2C. Increase in 1 has no effect on 2Answer: {{…
Published	07/30/2024	The only fluoroquinolone metabolized in the liver is {{c1::Moxifloxacin}}
Published	07/30/2024	VR 1. Fluoroquinolones 2. DiarrheaA. Increase in 1, increase in 2B. Increase in 1, decrease in 2C. Increase in 1 has no effect on 2Answer: {{c1::A}}
Published	07/30/2024	Fluoroquinolones ADRs: {{c1::Insomnia, Arthropathy, Tendinitis, peripheral neuropathy}}
Published	07/30/2024	{{c1::Ciprofloxacin}} is the drug of choice for treatment of anthrax
Published	07/30/2024	The fluoroquinolone alternative/s to ceftriaxone for gonorrhea is/are {{c1::Gemifloxacin (with azithromycin)}}
Published	07/30/2024	The fluoroquinolone alternative/s for chlamydial urethritis or cervicitis is/are {{c1::Levofloxacin and ofloxacin}}
Published	07/30/2024	Fluoroquinolones as 2nd line TB agest are {{c1::Ciprofloxacin, levofloxacin, or moxifloxacin}}
Published	07/30/2024	These fluoroquinolones may cause photosensitivity: {{c1::Lomefloxacin and pefloxacin}}
Published	07/30/2024	These fluoroquinolones cannot be given in combination with drugs that prolong QT intervals (antiarrhythmic drugs): {{c1::Gatifloxacin, levofloxacin, g…
Published	07/30/2024	QC Hyperglycemia (adverse effect) 1. Gemifloxacin 2. GatifloxacinA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	QC Hypoglycemia (adverse effect) 1. Gemifloxacin 2. GatifloxacinA. 1>2B. 1<2C. 1=2Answer: {{c1::B}}
Published	07/30/2024	Can fluoroquinolones be given during pregnancy?{{c1::N. Avoided::Y/N}}
Published	07/30/2024	VR 1. Fluoroquinolones 2. TendinitisA. Increase in 1, increase in 2B. Increase in 1, decrease in 2C. Increase in 1 has no effect on 2Answer: {{c1::A}}
Published	07/30/2024	QC Peripheral neuropathy 1. With fluoroquinolones 2. Without fluoroquinolonesA. 1>2B. 1<2C. 1=2Answer: {{c1::A}}
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