Notes in 009 - Neuromuscular Junction

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Published	10/01/2024	Outline how AChRs cluster together during NMJ formation{{c1::Initially, muscle fibres express AChR RNA everwhere}}{{c1::Nerve terminal spontaneously r…
Published	10/01/2024	Embryonic to Adult ACh receptor structure{{c1::\(\ce{\alpha_2\beta\gamma\delta}\) to \(\ce{\alpha_2\beta\epsilon\delta}\)}}
Published	10/01/2024	There is a transition from {{c1::multiple}} to {{c1::focal}} innervation after birthThis means babies go from {{c2:: ~3}} nerve terminals per muscle a…
Published	10/01/2024	Motor unit size determines {{c1::precision}} of unit
Published	10/01/2024	The smaller the motor unit, the more {{c1::precise}} it is
Published	10/01/2024	The cell body of motor neurones are found in the {{c1::ventral horn}} of a spinal cord segment
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Published	10/01/2024	Quantal content is the amount of {{c1::acetylcholine}} inside a vesicle
Published	10/01/2024	Outline quantal synaptic transmission{{c1::An ACh quanta will evoke an end plate potential (EPP)}}{{c1::Each successive quanta will increase EPP addit…
Published	10/01/2024	Typically slow, red muscles (e.g. soleus) express {{c1::alpha-actinin-2}} and {{c1::troponin I slow (TnIs)}}
Published	10/01/2024	Typically fast, white muscles (e.g. tibialis anterior) express {{c1::alpha-actinin-2}}, {{c1::alpha-actinin-3}} and {{c1::troponin I fast (TnIf) …
Published	10/01/2024	Strength of muscle contraction is dependent on the frequency of {{c1::motor neurone action potentials}}
Published	10/01/2024	Neurones within a motor unit fire Action Potentials {{c1::assynchronously}}The strength of muscle contraction can be increased by the {{c1::asynchrono…
Published	10/01/2024	Each muscle fibre contracts with a {{c1::twitch}}
Published	10/01/2024	How does atracurium act as an NMJ blocking agent?{{c1::AChR antagonist}}
Published	10/01/2024	Margin of safety - Iceberg effectOnly {{c1::10}}% of AChR on the motor end plate need to be open for an AP to be genereated
Published	10/01/2024	Margin of safety - Iceberg effectAbout {{c1::5::#}} times the number of ACh is released from the nerve terminal than needed to evoke an AP
Published	10/01/2024	Margin of safety - Iceberg effectAbout {{c1::75::#}}% of AChRs need to be blocked to reduce epp below threshold and induce partial paralysis
Published	10/01/2024	Margin of safety - Iceberg effectComplete muscle paralysis is induced when AChR block is at {{c1::95::#}}%
Published	10/01/2024	Name 3 non-depolarising neuromuscular blocking agents{{c1::Pancuronium}}{{c1::Vecuronium}}{{c1::Rocuronium}}
Published	10/01/2024	Name one depolarsing neuromuscular blocking drug{{c1::Succinylcholine}}
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