Notes in THER 201

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Adrenergic Agents & Blockers
Cholinergic Agents and Blockers

Status	Last Update	Fields
Published	01/01/2024	Types of Protein Targets (Receptor-mediated) w/ examples
Published	01/01/2024	Types of Receptor-mediated Drug Actions w/ examples
Published	01/01/2024	Types of D+R Interactions w/ examples
Published	01/01/2024	Define desensitization
Published	01/01/2024	Define tachyphylaxis. Give an example.
Published	01/01/2024	Types of Non-Receptor Mediated Drugs w/ examples
Published	01/01/2024	Types of Antagonism. Differentiate.
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Epinephrine
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Acarbose, Voglibose, Miglibose
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Dapagliflozin
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Colchicine
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Nicotine
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Benzodiazepine: Diazepam
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Lidocaine
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Kinase: Insulin receptor
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Salbutamol
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Estrogen
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Morphine
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Isoproterenol
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Naloxone
Published	01/01/2024	Give an example: Opioid agonist, Opioid competitive antagonist
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Atropine
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Ketamine
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Dimercaprol
Published	01/01/2024	Identify type, R, E, Effect, & Disease: DMSA
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Antacid
Published	01/01/2024	Identify type, R, E, Effect, & Disease: otassium acid phosphate, NH4Cl
Published	01/01/2024	Identify type, R, E, Effect, & Disease: Mannitol
Published	01/01/2024	Identify route of administration: drug is delivered to the epithelium of the nasal cavity.
Published	01/01/2024	Identify route of administration: First pass metabolism
Published	01/01/2024	Identify route of admin: Delivery of drug into CSF
Published	01/01/2024	Classify the following drug according to its functional intent or purpose: Levothyroxine
Published	01/01/2024	Drug name: Accepted worldwide
Published	01/01/2024	Drug name: particular formulation
Published	01/01/2024	Drug name: legally-registered brand
Published	01/01/2024	It makes up 20% of the drugs in the market. Small or large molecule drugs?
Published	01/01/2024	Drug name: Mandated or assigned by an official governing body
Published	01/01/2024	Identify route of admin: Delivered in the form of aerosols
Published	01/01/2024	Drug name: chemical structure
Published	01/01/2024	Classify the following drug according to its functional intent or purpose: Azithromycin
Published	01/01/2024	Identify route of admin: needs to diffuse across the skin and be absorbed into the bloodstream
Published	01/01/2024	Classify the following drug according to its functional intent or purpose: Amitryptylline
Published	01/01/2024	Receptor or non-receptor mediated: Allosteric binding
Published	01/01/2024	Receptor or non-receptor mediated: Alkalinization of urine to facilitate excretion of slightly acidic drugs
Published	01/01/2024	Binding of drugs in most receptors is due to interaction of drug with what biomolecule?
Published	01/01/2024	G proteins are part of what domain in D-R binding?
Published	01/01/2024	Effect of Empagliflozin
Published	01/01/2024	What part of the cell does Colchicine act?
Published	01/01/2024	Receptor of Ketamine
Published	01/01/2024	Effects of Gabapentin
Published	01/01/2024	Receptor of Insulin
Published	01/01/2024	What drug is a competitive antagonist of ACh?
Published	01/01/2024	A diminished biosynthesis of drug receptor
Published	01/01/2024	It is a drug that compete with the agonist at its binding site to prevent binding of other molecules, but it has no intrinsic efficacy
Published	01/01/2024	Give an example of a positive allosteric modulator or activator.
Published	01/01/2024	Give an example of a chemical antagonist
Published	01/01/2024	It refers to the addition of genetic material to cells to prevent, alleviate or cure disease
Published	01/01/2024	Explain the Occupational Theory of Ax
Published	01/01/2024	Parameters in Graded-dose response curve?
Published	01/01/2024	It refers to the concentration at which D elicits 50% of its maximal response.
Published	01/01/2024	It refers to the concentration at which half of the receptors are bound.
Published	01/01/2024	(A) does not consider the slopes of dose-response curves. (B) does.
Published	01/01/2024	It is the range of doses that provides safe and effective therapeutic response without significant adverse effects.
Published	01/01/2024	It undergoes hepatic cytochrome metabolism for which metabolic products are the active drug.
Published	01/01/2024	Metabolic interactions related to cytochrome inhibition or induction is related to which type of drug-drug interaction mechanism?
Published	01/01/2024	T/F: Polymorphisms of drug targets may affect receptors, leading to decreased binding of drug and increased efficacy.
Published	01/01/2024	Which is a competitive, noncompetitive inhibitor?
Published	01/01/2024	Identify its approach to drug discovery: Zanamivir
Published	01/01/2024	Identify its approach to drug discovry: Artemisin
Published	01/01/2024	Identify its approach to drug discovery: Human Insulin
Published	01/01/2024	3 Branches of Pharmacology. Differentiate each.
Published	01/01/2024	Father of Philippine Pharmacology
Published	01/01/2024	When was the Dept of Pharmacology established?
Published	01/01/2024	3 Types of Drug Nomenclature. Differentiate.
Published	01/01/2024	Drug Nomenclature of Biogesic
Published	01/01/2024	Drug Nomenclature of Aspirin
Published	01/01/2024	Drug Classification accdg to Function w/ examples
Published	01/01/2024	Drug Classification of Pro, Estro
Published	01/01/2024	Drug Classification of Opioids,
Published	01/01/2024	Main Routes of Administration
Published	01/01/2024	Differentiate routes of administration under Enteral type
Published	01/01/2024	Examples of drugs with G protein coupled receptors
Published	01/01/2024	Give examples for Acidifying & Alkalinizing Ds
Published	01/01/2024	Affinity vs Intrinsic Efficacy
Published	01/01/2024	As gene-based Tx, live oncolytic herpes virus is used to treat what?
Published	01/01/2024	Receptor upregulation vs downregulation
Published	01/01/2024	Emax vs EC50
Published	01/01/2024	EC50 vs Kd
Published	01/01/2024	Therapeutic Index vs. Margin of Safety
Published	01/01/2024	Therapeutic Index vs. Window
Published	01/01/2024	It is used to treat heart failure and cardiac rhythm problems, but it has a narrow TI & TW.
Published	01/01/2024	Drugs to use with caution
Published	01/01/2024	X & Y axes labels in Pharmacodynamics, Pharmacokinetics
Published	01/01/2024	What chemical properties make D best absorbed?
Published	01/01/2024	What chemical properties of D make it best distributed through tissue?
Published	01/01/2024	Formula for Vd
Published	01/01/2024	3 Phases of Metabolism accdg to function
Published	01/01/2024	It is the most common rxn & the only one ocurring in the liver microsomal sys. Under what phase of metabolism is it?
Published	01/01/2024	Examples of Ds under Phase 1, 2 of metabolism
Published	01/01/2024	In what organ does metabolism, excretion primarily take place?
Published	01/01/2024	How does detoxification from Aspirin OD work?
Published	01/01/2024	Prodrug vs drug in terms of dose
Published	01/01/2024	What drugs are metabolized by CYP2D6?
Published	01/01/2024	Genes of interest in the PH w/ regards to SNPs, Cardiovascular drugs
Published	01/01/2024	Demographic with higher incidence of D Adverse Rxn
Published	01/01/2024	What drugs have a higher incidence of Adverse D Rxn in High Income countries?
Published	01/01/2024	What drugs have a higher incidence of Adverse D Rxn in Low Income countries?
Published	01/01/2024	6 Types of Adverse Drug Rxn with examples
Published	01/01/2024	Augmented, Chronic, vs. Delayed Adverse D Rxn
Published	01/01/2024	Demographic with Adverse D Interaction (⬇️D efficacy, ⬆️D Toxicity)
Published	01/01/2024	Pharmacokinetics of D often associated with Adverse D Interaction
Published	01/01/2024	Types of Adverse D Interactions
Published	01/01/2024	Identify type of Adverse D Interaction: Phenytoin & Dextrose, Phenytoin capsule filter/CaS & Lactose
Published	01/01/2024	Identify type of Adverse D Interaction: Propanolol (ADRB Antagonist) & Verapamil (Ca-channel blocker)
Published	01/01/2024	Identify type of Adverse D Interaction: NSAID & Captopril (ACE Inhibitor)
Published	01/01/2024	Hit vs Lead compound
Published	01/01/2024	Define drug idiosyncrasy
Published	01/01/2024	Identify the toxicity study type: Administration of the same dosage daily
Published	01/01/2024	Identify the toxicity study type: Administration of graduated dosage daily for 90 days
Published	01/01/2024	Identify the toxicity study type: Administration of graduated dosage daily for 6-12mo
Published	01/01/2024	Target incidence of HTN by 2030
Published	01/01/2024	Duration of Traditional vs. Conventional medicine drug dev
Published	01/01/2024	Lagundi (Vitex negunda) is used as Tx for?
Published	01/01/2024	Sambong (Blumea balsamifera) is used as Tx for?
Published	01/01/2024	Ulasimang bato (Peperomia pellucida) is used as Tx for?
Published	01/01/2024	Yerba buena (Mentha arvensis) is used as Tx for?
Published	01/01/2024	Tsaang gubat (Ehretia microphylla) is used as Tx for?
Published	01/01/2024	Akapulko (Senna alata) is used as Tx for?
Published	01/01/2024	Ampalaya (Momordica charantia) is used as Tx for?
Published	01/01/2024	Warfarin exhibits anticoagulant effects via which clotting factors?
Published	01/01/2024	What parameters increase, decrease with corticosteroid administration?
Status	Last Update	Fields