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Notes in 18 Anti-Mycobacterials, Anti-COVID, Anti-Fungals

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Published 07/30/2024 ANTI-COVID-19 DRUGSClinical PresentationsFamiliarize {{c1::me}}
Published 07/30/2024 ANTI-COVID-19 DRUGSInvestigational TherapyANTIVIRALSIMMUNOMODULATORSIMMUNE-BASED THERAPY  {{c1:: PaxlovidRemdesevirMolnupiravir }}    {…
Published 07/30/2024 ANTI-COVID-19 DRUGSDOC of COVID for OPD (Hierarchy){{c1::1. Paxlovid2. Remdesevir3. Molnupiravir}}
Published 07/30/2024 ANTI-COVID-19 DRUGSFIRST LINE FOR INPATIENTS{{c1::1. Remdesivir2. Dexamethasone}}
Published 07/30/2024 ANTI-COVID-19 DRUGSVaccines{{c1::Monovalent}}{{c1::Bivalent}}{{c2::Only effective against Original SARS-CoV-2}}  {{c2:: For Omicron Variant BA.4 …
Published 07/30/2024 ANTI-COVID-19 DRUGSVaccinesFeature{{c1::Novovax}}{{c2::Moderna}}{{c3::Pfizer}}Type{{c1::Protein subunit}}{{c2::mRNA}}{{c3::mRNA}}Content{{c1::Recombin…
Published 07/30/2024 ANTI-COVID-19 DRUGS{{c1::TIXAGEMIVAB + CILGAVIMAB}}Brand name: {{c2::Evusheld}}MOA: {{c2::receptor binding domain of S1 Subunit of spike protein → Pre…
Published 07/30/2024 ANTI-COVID-19 DRUGS{{c1::TIXAGEMIVAB + CILGAVIMAB}}Indications:{{c2::Age: >12years oldWeight: ≥ 40 kgModerately to severely immunocompromised …
Published 07/30/2024 ANTI-COVID-19 DRUGSOPD Treatment Options{{c1::Ritonavir Boosted Nirmatrelvir/Paxlovid}}Main drug: {{c2::Ritonavir}}Booster: {{c2::Nirmatrelvir}}MOA: {…
Published 07/30/2024 ANTI-COVID-19 DRUGSOPD Treatment Options{{c1::Molnupiravir}}MOA: {{c2::Viral lethal mutagenesis via the nucleoside analogue}}Role in COVID: {{c2::Decr…
Published 07/30/2024 ANTI-COVID-19 DRUGSInpatient Treatment Options{{c1::Remdesivir}}MOA: {{c2::Binds and inhibits the viral RNA-dependent RNA polymerase}}Role in COVID: {…
Published 07/30/2024 ANTI-COVID-19 DRUGSInpatient Treatment Options{{c1::Steroids (Dexamethasone)}}MOA: {{c2::Inhibition of pro-inflammatory cytokine production}}Use in CO…
Published 07/30/2024 ANTI-COVID-19 DRUGSInpatient Treatment Options{{c1::Baricitinib}}MOA: {{c2::Inhibits JAK Kinase and prevents entry of SARS-COV-2 virus into human cell…
Published 07/30/2024 ANTI-COVID-19 DRUGSInpatient Treatment Options{{c1::Tocilizumab}}MOA: {{c2::IL-6 Receptor Antagonist}}Use in COVID: {{c2::Prompt improvement in clinic…
Published 07/30/2024 ANTI-COVID-19 DRUGSOther Supportive Management{{c2::Vitamin C and Zinc}}Helps increase the immune system to be resistant against secondary bacterial i…
Published 07/30/2024 ANTIFUNGALSPolyene Antibiotics{{c1::Amphotericin B}}MOA: {{c2::Binds to ergosterol through forming aggregates of pores or squentially inserting pores …
Published 07/30/2024 ANTIFUNGALSPolyene AntibioticsAmphotericin BAdE{{c1::Anemia, Muscle spasm, Phlebitis, Headache, Hypotension, Ototoxicity, Neurotoxicity, Nephrotoxicit…
Published 07/30/2024 ANTIFUNGALSPolyene Antibiotics{{c1::Nystatin}}MOA: {{c2::Binds to ergosterol}}Indications: {{c2::Candidiasis (Oral and Vaginal)}}Drug interactions: {{…
Published 07/30/2024 ANTIFUNGALS{{c1::Azoles}}MOA: {{c2::Inhibits fungal CYP450 enzyme lanosterol 14-demethylase → DEC ergosterol synthesis}}Indications: {{c2::Aspergillos…
Published 07/30/2024 ANTIFUNGALSAzolesIMIDAZOLETRIAZOLE{{c1::Ketoconazole, Miconazole, Clotrimazole}}{{c2::Itraconazole, Fluconazole, Voriconazole, Pos…
Published 07/30/2024 ANTIFUNGALSAzoles{{c1::Ketoconazole}}{{c2::Negligible}} CSF penetrationIndications: {{c2::Mucocutaneous infection, Systemic mycoses (seborrheic d…
Published 07/30/2024 ANTIFUNGALSAzoles{{c1::Miconazole}}Readily penetrates {{c2::stratum corneum}}Indications: {{c2::Vaginal candidiasis, Tinea corporis/pedis/cruris}…
Published 07/30/2024 ANTIFUNGALSAzoles{{c1::Fluconazole}}Best bet for {{c1::systemic infections}} ← {{c1::Least::Least/Most}} hepatotoxicIndications: DOC fo…
Published 07/30/2024 ANTIFUNGALSAzoles{{c1::Itraconazole}}Indications: {{c2::Prophylaxis in BM transplant patients, Non-meningeal infections }}DOC for: {{c2…
Published 07/30/2024 ANTIFUNGALSAzoles{{c1::Voriconazole}}Indications: {{c2::Aspergillosis in neutropenic patients, Candidiasis}}DOC for: {{c2::Invasive Aspergillosis…
Published 07/30/2024 ANTIFUNGALSAzoles{{c1::Posaconazole}}Indications: {{c2::Broadest::Broadest/Narrowest}} spectrum of all the azolesGreatest activity against {{c2::…
Published 07/30/2024 ANTIFUNGALSAzoles{{c1::Isavuconazole}}The only azole that does not cause {{c2::QTc prolongation::adverse effect}}PK{{c2::DEC::INC/DEC}} with food; goo…
Published 07/30/2024 ANTIFUNGALSPyrimidine Analog{{c1::Flucytosine}}MOA: {{c2::Inhibits DNA and RNA synthesis}}Indications: {{c2::C. neoformans meningitis in HIV, Chr…
Published 07/30/2024 ANTIFUNGALSHeterocyclic Benzofuran{{c1::Griseofulvin}}MOA: {{c2::Bind to microtubules and newly formed keratin → inhibit fungal mitosis}}Indication: {…
Published 07/30/2024 ANTIFUNGALSAllylamine{{c1::Terbinafine}}MOA: {{c2::Reversible noncompetitive inhibition of squalene epoxidase or monooxygenase}}Indication: {{c2::Skin…
Published 07/30/2024 ANTIFUNGALS{{c1::Echinocandins}}{{c2::Last line of defense}} for all fungal infectionsMOA: {{c2::Inhibits synthesis of B 1-3 glucan}}PK: {{c2::Extensi…
Published 07/30/2024 ANTIFUNGALSEchnocandins CaspofunginMicafunginAnidulafunginWater solubility{{c1::Yes}}{{c2::Yes}}{{c3::No}}Half life{{c1::10}}{{c2::13}}{{c3::25.6…
Published 07/30/2024 ANTIFUNGALSOther Antifungals{{c1::Albendazole::drug}}: {{c2::Microsporidia spp.::fungus}}{{c1::TMP-SMX::drug}}: {{c2::Pneumocystis carinii::fungus}}{{…
Published 07/30/2024 1st Line Drugs for TB: {{c1::Isoniazid, Rifampicin, Pyrazinamide, Ethambutol (HRZE)}}
Published 07/30/2024 2nd Line Injectable Drugs for TB: {{c1::Aminoglycosides: Streptomycin, Amikacin (, Kanamycin & Capreomycin)}}
Published 07/30/2024 2nd Line Oral Drugs or Group A for MDR-TB: {{c1::Moxifloxacin , Bedaquiline, Pretomanid, Linezolid}}
Published 07/30/2024 [QC] Bactericidal1. H2. R3. Z4. E{{c1::H > R > E > Z}}
Published 07/30/2024 [QC] Sterilizing1. H2. R3. Z4. E{{c1::R > Z > H > E}}
Published 07/30/2024 The most potent Anti-TB drug for intracellular organisms is {{c1::Z}}
Published 07/30/2024 {{c1::H::Anti-TB Drug}} targets the TB populations in the cavitary walls and w/ highest metabolic activity
Published 07/30/2024 {{c1::R::Anti-TB Drug}} targets the TB populations in the caseous material w/ intermittent metabolic activity
Published 07/30/2024 {{c1::Z::Anti-TB Drug}} targets the TB populations in the macrophages and caseous material w/ intermittent metabolic activity
Published 07/30/2024 New or Retreatment PTB or EPTB (Except CNS, Bones, and Joints) w/ final Xpert Result or (+) SM/TB Lamp Regimen:{{c1::Regimen I (2HRZE/4HR)}}
Published 07/30/2024 New or Retreatment EPTB (CNS, Bones, and Joints) w/ final Xpert Result or (+) SM/TB Lamp or clinically diagnosed Regimen:{{c1::Regimen II (2HRZE/10HR)…
Published 07/30/2024 INH MOA: Activated by {{c1::KatG/Mycobacterial Catalase Peroxidase}} → {{c2::Isonicotinic Acid}}
Published 07/30/2024 INH (H) MOA:1. Isonicotinic Acid complexes w/ {{c1::carrier protein synthase}} to block mycolic acid synthesis2. Isonicotinic Acid inhibits {{c1::NADH…
Published 07/30/2024 INH (H) MOR:{{c1::KatG Gene Mutation/DeletioninhA Overexpression::2}}
Published 07/30/2024 [QC] INH Resistance1. KatG Gene Mutation/Deletion2. inhA Overexpression{{c1::A}}
Published 07/30/2024 [QC] Cross-resistance w/ ethionamide1. KatG Gene Mutation/Deletion2. inhA Overexpression{{c1::B}}
Published 07/30/2024 First line TB Drugs are metabolized in the {{c1::liver}}
Published 07/30/2024 First line TB Drugs that excreted through the urine and renal dose adjustment are {{c1::PZA and EMB::2}}. {{c1::RIF}} is excreted through the bile
Published 07/30/2024 [VR]1a. INH1b. RIF2. CYP450 Activity1a. {{c1::B}}1b. {{c1::A}}
Published 07/30/2024 INH DI:INH suspension can be inactivated by Vit. {{c1::C}}
Published 07/30/2024 INH ADE: {{c1::Peripheral Neuropathy (most common), Hepatitis (most common majort), G6PD Deficiency Hemolysis::3}}
Published 07/30/2024 How does INH cause peripheral neuropathy?{{c1::promotes pyridoxine excretion}}
Published 07/30/2024 Pyridoxine formulation to combat peripheral neuropathy in INH:Prophylaxis: {{c1::25}} mgTx: {{c1::100}} mg
Published 07/30/2024 RIF MOA: Binds to {{c1::𝛽 subunit of DNA dependent RNA polymerase}}
Published 07/30/2024 RIF DI: Decreases the efficacy of {{c1::OCPs and Sulfonylureas::2 Drugs}}
Published 07/30/2024 How does RIF improve the tx for leprosy?{{c1::Delays emergence of resistance to dapsone is given monthly}}
Published 07/30/2024 RIF may be used w/ {{c1::vancomycin}} for MRSA or PRSP
Published 07/30/2024 RIF ADE:{{c1::Orange-Red Fluid Discoloration (urine, sweat, tears)Flu-like Syndrome::2}}
Published 07/30/2024 EMB MOA:{{c1::Binds to embCAB operon → Inhibits arabinosyl transferase → Interferes with cell wall synthesis}}
Published 07/30/2024 EMB Formulation:Bacteriostatic: {{c1::15}} mg/kg/dayBactericidal: {{c1::25}} mg/kg/day
Published 07/30/2024 How does EMB improve Anti-TB regimen?Decreases {{c1::RIF}} resistanceBoosts activity of {{c1::INH and RIF}}
Published 07/30/2024 EMB MOR:{{c1::Overexpression of the emb gene productsGene mutation in the embB structure::2}}
Published 07/30/2024 {{c1::EMB}} DI: Delayed absorption by {{c2::AlOH}}
Published 07/30/2024 EMB DI: Decreases concentration of {{c1::theophylline}}
Published 07/30/2024 Which Anti-TB drug decreases the immunologic response to vaccines in children?{{c1::EMB}}
Published 07/30/2024 EMB ADE:{{c1::Irreversible retrobulbar neuritis leading to ↓ visual acuityloss of red-green color discrimination::2}}
Published 07/30/2024 Do not give EMB to px <{{c1::6}} y/o
Published 07/30/2024 PZA is chemically similar to {{c1::INH}}
Published 07/30/2024 PZA MOA:Binds to {{c1::ribosomal proteins S1}} that affects {{c2::FA}} synthesisTargets {{c1::NADH redox}} that affects {{c2::mycolic acid}} synthesis
Published 07/30/2024 This anti-TB drug acidifies the cell wall{{c1::PZA}}
Published 07/30/2024 PZA MOA:Activated by Pyrazinamidase encoded by {{c1::pncA}} → {{c2::Pyrazinoic Acid}}
Published 07/30/2024 PZA MOR:{{c1::pncA gene mutationImpaired PZA uptake::2}}
Published 07/30/2024 PZA ADE:{{c1::HyperuricemiaIrreversible Hepatotoxicity::2}}
Published 07/30/2024 Adult HRZE Formulation: {{c1::75}}/{{c1::150}}/{{c1::400}}/{{c1::275}} mg w/ {{c1::4}} tablets per day for px {{c1::55-70}} kg
Published 07/30/2024 Pediatric HRZE Formulation: 75/150/400/275 mg w/ {{c1::3}} tablets per day for px {{c1::12-15}} kg
Published 07/30/2024 Px w/ {{c1::Primary}} Resistance to Anti-TB Drugs deny having had an anti-TB tx for more than a month
Published 07/30/2024 Px w/ {{c1::Secondary}} Resistance to Anti-TB Drugs developed resistance to >/=1 drug in tx
Published 07/30/2024 Stopping Anti-TB medications for {{c1::1}} month/s or more is a risk factor for secondary resistance
Published 07/30/2024 Resistance to only {{c2::INH and RIF}} drugs is called {{c1::M}}DR-TB
Published 07/30/2024 Resistance to only {{c2::INH +/- RIF, any fluoroquinolone, and >/= injectable}} drug is called {{c1::X}}DR-TB
Published 07/30/2024 Tx Period for DR-TB lasts for {{c1::6}} months for intensive, {{c1::12-18}} months for maintenance
Published 07/30/2024 2nd Line Group B Drugs for MDR-TB: {{c1::Cycloserine, Clofazimine, Terizidone::3}}
Published 07/30/2024 2nd Line Group C Drugs for MDR-TB: {{c1::Injectable Aminoglycosides, Ethionamide, PAS, Rifapentine & Rifabutin::5}}
Published 07/30/2024 Fluoroquinolones target TB bacilli in {{c1::macrophages}}
Published 07/30/2024 [QC] Safety Profile1. Moxifloxacin2. Levofloxacin{{c1::B}}
Published 07/30/2024 [QC] Atypical Mycobacteria1. Moxifloxacin2. Levofloxacin{{c1::B}}
Published 07/30/2024 [QC] G (+)1. Moxifloxacin2. Levofloxacin{{c1::A}}
Published 07/30/2024 Fluoroquinolones are well absorbed unless in the presence of {{c1::cations}}
Published 07/30/2024 Fluoroquinolones have a {{c1::↑::↑/↓}} Vd
Published 07/30/2024 Bedaquiline MOA: {{c1::Binds and inhibits subunit C of ATP synthase (proton pump)}}
Published 07/30/2024 Bedaquiline MOR: Mutation in efflux pump encoded by {{c1::MmpL5 gene}}
Published 07/30/2024 Bedaquiline MOR: Can have cross resistance w/ {{c1::clofazimine}}
Published 07/30/2024 Bedaquiline good absorption w/ {{c1::high fat food}}
Published 07/30/2024 Can bedaquiline cross the BBB?{{c1::Yes but Poor BBB penetration}}
Published 07/30/2024 Bedaquiline is metabolized by CYP{{c1::3A4}} in the liver
Published 07/30/2024 Bedaquiline is excreted through the {{c1::feces}}
Published 07/30/2024 Bedaquiline DI: Do not use w/ {{c1::rifampin}} and {{c1::rifapentine}} because it causes mortality
Published 07/30/2024 Bedaquiline ADE:{{c1::QTc ProlongationHepatottoxicity::2}}
Published 07/30/2024 Almost aall 2nd Line Anti-TB drugs are metabolized in the liver except for {{c1::delamanid}} metabolized by {{c1::albumin}}
Published 07/30/2024 Linezolid is excreted through the {{c1::urine}}
Published 07/30/2024 Linezolid DI: Causes serotonin syndrome when used w/ {{c1::serotonergic agents}}
Published 07/30/2024 Linezolid ADE: {{c1::BM SuppressionIrreversible Peripheral & Optic NeuropathyPancreatitis::3}}
Published 07/30/2024 Pretomanid MOA: Aerobic: {{c1::Inhibit mycolic acid cell wall}}Anaerobic: {{c1::Release ROS}}Targets the {{c1::pentose phosphate}} pathway for th…
Published 07/30/2024 Pretomanid is well absorbed with {{c1::high fat food and a caloric meal}}
Published 07/30/2024 Pretomanid is excreted through the {{c1::urine}}
Published 07/30/2024 Pretomanid DI: Safe to give to px taking multiple drugs except for {{c1::rifampicin}} and {{c1::efavirenz}}
Published 07/30/2024 Pretomanid ADE:{{c1::QTc Prolongation}} within the first {{c1::3}} monthsLab: testicular toxicity, post implantation loss, cataract, ataxia, and convu…
Published 07/30/2024 Cycloserine is the structural analog of {{c1::D-alanine}}
Published 07/30/2024 Cycloserine MOA:Inhibit {{c1::alanine racemase}} which synthesize pentapeptide core essential in peptidoglycan cell wall synthesis
Published 07/30/2024 Can Cycloserine cross the BBB and Placenta?{{c1::Y::Y/N}}
Published 07/30/2024 Aside from TB, Cycloserine can also be used for {{c1::MAC}} infections
Published 07/30/2024 Cycloserine DI: {{c1::ISMN}} and {{c1::Thionamide}} make ADE more prominent
Published 07/30/2024 Cycloserine ADE: {{c1::SeizuresPsychosesDepressionPeripheral Neuropathy}}
Published 07/30/2024 The most favorable drug in Group B 2nd Line Anti-TB drugs is {{c1::Delamanid}} because it can be given to lactating mothers
Published 07/30/2024 Delamanid MOA: Inhibits {{c1::mycolic acid}} synthesis
Published 07/30/2024 {{c1::delamanid::2nd line Group B}} decreases resistance to anti-TB drugs
Published 07/30/2024 Delamanid is excreted through the {{c1::stool}}
Published 07/30/2024 Delamanid DI: {{c1::Almost none}}
Published 07/30/2024 Delamanid ADE: {{c1::QTc ProlongationParesthesiaHallucinations and Night Terrors::3}}
Published 07/30/2024 Streptomycin targets {{c1::ex}}tracellular TB bacilli
Published 07/30/2024 Streptomycin MOR: {{c1::rpsL}} or {{c1::rrs}} gene mutation
Published 07/30/2024 Streptomycin is excreted through the {{c1::urine AND MILK!}}
Published 07/30/2024 Streptomycin is for extensive {{c1::cavitary}} TB
Published 07/30/2024 Streptomycin DI: ↑ Concentration w/ {{c1::loop diuretics}} meaning ↑ ADE
Published 07/30/2024 Streptomycin ADE: {{c1::Vestibular OtotoxicityNephrotoxicity::2}}
Published 07/30/2024 2nd Line Injectable Drugs have cross resistance to each other except for {{c1::streptomycin}}
Published 07/30/2024 Amikacin is excreted through the {{c1::urine}}
Published 07/30/2024 Capreomycin is excreted through the {{c1::urine}}
Published 07/30/2024 Kanamycin is excreted through the {{c1::feces}}
Published 07/30/2024 Kanamycin and Amikacin ADE:{{c1::Irreversible Auditory Ototoxicity}}
Published 07/30/2024 Capreomycin ADE:{{c1::Vestibular and Auditory OtotoxicityNephrotoxicity}}
Published 07/30/2024 1st favorable drug in Group C 2nd Line Anti-TB drugs is {{c1::Ethionamide/Prothionamide}}2nd is {{c1::Aminosalicyclic acid (PAS)}}
Published 07/30/2024 Ethionamide/Prothionamide MOA: {{c1::Mycolic acid synthesis inhibitor}}
Published 07/30/2024 Ethionamide/Prothionamide MOR: {{c1::inhA}} mutation
Published 07/30/2024 Ethionamide/Prothionamide MOA: Activated by {{c1::enzyme FA or monooxygenase}}
Published 07/30/2024 Ethionamide/Prothionamide is excreted through the {{c1::urine}}
Published 07/30/2024 Ethionamide/Prothionamide ADE:{{c1::PsychosesGastric IrritationMetallic TasteHypothyroidismPeripheral Neuropathy::5}}
Published 07/30/2024 Aminosalicyclic Acid (PAS) is structurally similar to {{c1::p-aminobenzoic}} acid
Published 07/30/2024 Aminosalicyclic Acid (PAS) MOA: Competitive inhibitor of {{c1::dihydropteroate synthase}}
Published 07/30/2024 Can Aminosalicylic acid cross the BBB?{{c1::N::Y/N}}
Published 07/30/2024 Aminosalicylic acid is excreted through the {{c1::urine}}
Published 07/30/2024 Aminosalicylic acid ADE:{{c1::GI ulcers and hemorrhageHypothyroidismHepatitis::3}}
Published 07/30/2024 Rifapentine & Rifabutin MOA: Inhibits {{c1::RNA Polymerase}}
Published 07/30/2024 Rifapentine & Rifabutin MOR: Same as {{c1::rifampicin}}
Published 07/30/2024 Aside from MDR-TB and XDR-TB, rifapentine and rifabutin are also indication for {{c1::MAC, LTBI, and HIV px::3}}
Published 07/30/2024 [QC] Inducer of CYP4501. Rifabutin2. Rifapentine{{c1::B}}
Published 07/30/2024 Rifapentine & Rifabutin ADE:{{c1::LeukopeniaThrombocytopeniaAnterior uveitisArthralgiasHepatotoxicity::5}}
Published 07/30/2024 If giving Anti-TB Drugs to Pregnant and Breastfeeding px, always remember to give {{c1::Vit B6}} prophylaxis
Published 07/30/2024 Do not give {{c1::Injectable}} 2nd Line Anti-TB drugs to pregnant px
Published 07/30/2024 Interrupt Anti-TB Tx ifALT >{{c1::3}}x ULN w/ symptomsALT >{{c1::5}}x ULN w/o symptomsthen reintroduce when ALT <{{c1::2}}x
Published 07/30/2024 When treating px w/ TB meningitis and TB pericarditis, also give {{c1::steroids}} in a tapering dose for 6-8 weeks
Published 07/30/2024 In px w/ TB/HIV co-infection, take note of the onset of {{c1::immune reconstitution inflammatory syndrome}}
Published 07/30/2024 If a patient undergoing Anti-TB Regimen developed drug-induced liver injury, {{c1::PZA}} should NOT be reintroduced.Extend HRE for {{c2::9}} months OR…
Published 07/30/2024 Adult LTBI Regimen:{{c1::6H or4R::2}}
Published 07/30/2024 Pediatric LTBI Regimen:{{c1::3HP or4HR::2}}
Published 07/30/2024 Weekly dosing for LTBI:{{c1::3HP}}Contraindicated for {{c1::pregnant px and px <2 y/o}}Indicated for {{c1::px w/ HIV}}
Published 07/30/2024 Drugs for Atypical TB: {{c1::Macrolides, Doxycycline/Minocycline, Clotrimoxazolem, TMP-SMX::4}}
Published 07/30/2024 The most potent macrolide for px w/ atypical TB is {{c1::clarithromycin}}
Published 07/30/2024 The most potent macrolide for px w/ atypical TB INTRACELLULARLY is {{c1::Azithromycin}}
Published 07/30/2024 Macrolide MOR: {{c1::Drug efflux pump and production of methylase::2}}
Published 07/30/2024 Atypical TB Species Indicated under Macrolides:M. {{c1::avium}}M. {{c1::kansasii}}
Published 07/30/2024 Atypical TB Species Indicated under Clotrimoxazole and TMP-SMX:M. {{c1::marinum}}M. {{c1::kansasii}}M. {{c1::fortuitum}}
Published 07/30/2024 Macrolides DI: CYP3A4 in{{c1::hibitor}}
Published 07/30/2024 Macrolides ADE:{{c1::GI DisturbancesQTc Prolongation w/ ventricular tachycardiaHepatotoxicityHypoglycemia::4}}
Published 07/30/2024 Clotrimoxazole & TMP-SMX ADE:{{c1::Megaloblastic Anemia}}
Published 07/30/2024 Tx for paucibacillary leprosy lasts {{c1::6}} months
Published 07/30/2024 Tx for multibacillary leprosy lasts {{c1::12-24}} months
Published 07/30/2024 Paucibacillary Leprosy Regimen:AdultRifampin {{c1::600}} mg once a monthDapsone {{c1::100}} mg OD dailyChildrenR: {{c1::450}} mgD: {{c1::50}} mg
Published 07/30/2024 Multibacillary Leprosy Regimen:Paucibacillary Leprosy Regimen + {{c1::Clofazimine}} {{c2::300}} mg (adults) or {{c2::150}} mg (pediatric) once a month…
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