Review Note

{{c1::Bupropion}} is a {{c2::norepinephrine}} and {{c2::dopamine}} reuptake inhibitor w/ {{c2::nicotinic receptor}} activity.

Buproprion is often used as an ALT antidepressant to {{c3::SSRIs}}, or {{c3::SNRIs}} due to its lower risk for {{c4::sexual dysfunction}} or {{c4::wt gain}}, as well as second-line therapy for {{c5::smoking cessation}}.

Note 1: It enhances smoking cessation, but is less effective than varenicline and equivalent to single NRT; hence a third-line option
Note 2: Varenicline OR combo NRT (long- and short-acting) are first-line options for nicotine dependence therapy; improved outcomes w/ behavioral counseling
Note 3: Buproprion should be avoided in Pts w/ Hx of SZ or at increased risk of SZ e.g. anorexia or bulemia