Review Note
Last Update: 06/07/2023 07:24 PM
Current Deck: Coag
Published
Fields:
Front
Endothelial Influences on Clotting
Back
Intact layer of endothelial cells prevent binding of vWF
Endothelial cells release nitric oxide (NO)
NO is an inhibitor of platelet activation & aggregation
Endothelial cells metabolize arachidonic acid to prostacyclin
Prostacyclin is an inhibitor of platelet activation & aggregation
Endothelial cell membranes display thrombomodulin
Thrombomodulin binds thrombin & activates protein C
Protein C binds to protein S => inactivates cofactors VIII and V
Endothelial cells release nitric oxide (NO)
NO is an inhibitor of platelet activation & aggregation
Endothelial cells metabolize arachidonic acid to prostacyclin
Prostacyclin is an inhibitor of platelet activation & aggregation
Endothelial cell membranes display thrombomodulin
Thrombomodulin binds thrombin & activates protein C
Protein C binds to protein S => inactivates cofactors VIII and V
Fun fact
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