Review Note
Last Update: 06/22/2023 10:14 PM
Current Deck: Rutgers::CIHP::L04 Avoidable Toxicological Disasters in History: Prohibition
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MPTP outbreak occurred when injection drug users were attempting to use a meperidine analog, {{c1::MPPP (1-methyl-4-phenyl-4-propionocy-piperidine)}}
Metabolism of MPTP to MPP+ resulted in a
toxic compound that selectively destroyed
cells in the substantia nigra, depleting
dopamine stores or products and causing
severe and {{c1::irreversible parkinsonism }}
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