Review Note

pathophysiology of asthma:

- {{c1::early}} phase: Ig{{c2::E}} antibodies are sensitized and released by {{c3::plasma}} cells → respond to certain triggers in environment → bind to high-affinity mast cells and basophils
→ when a pollutant gets inhaled, {{c4::mast cells}} release cytokines and eventually de-granulate → release {{c5::histamine}}, prostaglandins, and leukotrienes → contract smooth muscle and cause airway tightening

- within the next several hours, {{c6::late}} phase occurs → eosinophils, basophils, neutrophils, and helper and memory T-cells all localize to {{c7::lungs}} → broncho{{c8::constriction::dilation/constriction?}} and cause inflammation