Review Note
Last Update: 08/30/2023 12:42 AM
Current Deck: ACMS Study Guide Deck::A. Cancers
PublishedCurrently Published Content
Front

Describe the Sonic Hedgehog pathway under normal conditions
Back
Normal conditions -
PTCH inhibits Smoothened signaling
Sonic Hedgehog (SHH) binds to extracellular receptor PTCH1 --> relieves PTCH1 inhibition of SMO (smoothened) --> activiate Gli -->Proliferation
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