Review Note

Last Update: 09/11/2023 07:51 PM

Current Deck: L34 NS Path 4 ( Demylinating Disease & Brain tumors)

Published

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Text

Multiple sclerosis is an {{c2::autoimmune}} destruction of CNS myelin and {{c1::oligodendrocytes}}

Extra

Type 4 HSR, particularly against myelin basic protein

- destruction is mediated by CD8 CTLs, Th17 cells, and Th1 cells that release IFN-y to activate MO that help cause damage

-Because there is loss of Myelin, both the conduction velocity and space (length) constant of nerves decrease; this also induces a conduction block (which over time can restore to some point)

- (space constant = length at which a nerve depolarization can travel until it decays to about 1/3 of its original potential)

Lecture Notes

Missed Questions

Pathoma

Boards and Beyond

First Aid

Sketchy

Pixorize

Physeo

OME

Additional Resources

Atlas:

Tags:

#AK_Step1_v10::#B&B::15_Neuro::01_Intro::01_Cells_of_the_Nervous_System #AK_Step1_v10::#B&B::15_Neuro::07_Other::05_Demyelinating_Diseases #AK_Step1_v10::#FirstAid::12_Neuro_&_Special_Senses::03_Pathology::17_Multiple_Sclerosis

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