Review Note

Last Update: 09/11/2023 07:51 PM

Current Deck: L34 NS Path 4 ( Demylinating Disease & Brain tumors)

Published

Fields:

Text

Bilateral {{c2::vestibular}} schwannomas are seen in {{c1::neurofibromatosis 2 (NF-2)}}

Extra

other symptoms of NF-2 include juvenile cataracts, meningiomas, and ependymomas

Lecture Notes

Missed Questions

Pathoma

Boards and Beyond

First Aid

Sketchy

Pixorize

Physeo

OME

Additional Resources

Ependymal pseudorosette

Photomicrograph of brain tissue (H&E stain)

Tumor cells (cylindrical epithelium) are arranged in a radial manner around several vessels. This pattern is called a perivascular pseudorosette.

Perivascular pseudorosettes are a hallmark of ependymoma.

Ependymoma

Photomicrograph of ependymal tissue (H&E stain)

There is an abnormally high number of cells with round nuclei and abundant cytoplasms. Some cells are arranged in a spoke-and-wheel pattern, surrounding an empty central lumen. Such patterns are called ependymal rosettes (example indicated by green overlay).
Other cells are arranged concentrically around vessels, producing a similar appearance (perivascular pseudorosettes; example indicated yellow overlay).

Ependymoma

Cranial MRI (FLAIR-sequence, sagittal view)

A hyperintense, heterogeneous, extended mass is visible on the roof of the 4th ventricle (white outline). At the superior aspect of the tumor, multiple cysts are present (white arrows). As a result of an obstructed circulation of the cerebrospinal fluid, the 3rd ventricle appears widened.

This is a typical radiologic presentation and location of ependymoma.

Atlas:

Tags:

#AK_Step1_v10::!FLAG_THESE_CARDS::Delete #AK_Step1_v10::#B&B::07_Derm::11_Neurocutaneous_Disorders #AK_Step1_v10::#B&B::15_Neuro::07_Other::07_Brain_Tumors

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