Review Note

Last Update: 09/11/2023 07:51 PM

Current Deck: L34 NS Path 4 ( Demylinating Disease & Brain tumors)

Published

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Text

Multiple sclerosis is characterized histologically by {{c1::perivenular}} inflammatory infiltrates

Extra

Composed primarily of autoreactive T lymphocytes and macrophages direct against myelin components; results in patchy demyelination and macrophages containing myelin debris

additionally, recruitment of B lymphocytes to the perivascular space leads to the formation of myelin specific antibodies

Lecture Notes

Autoimmune → episodes of diseases activity separated in time producing white matter lesions separated in space

Autoimmune response directed against myelin sheath components

Most common Th1 & Th17 reactive against myelin ages & secrete cytokine —> WBC recruitment & activation —> demyelination

Missed Questions

Pathoma

Boards and Beyond

First Aid

Sketchy

Pixorize

Physeo

OME

Additional Resources

Tags:

#AK_Step1_v10::#B&B::15_Neuro::07_Other::05_Demyelinating_Diseases #AK_Step1_v10::#FirstAid::12_Neuro_&_Special_Senses::03_Pathology::17_Multiple_Sclerosis #AK_Step1_v10::#OME_banner

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