Review Note
Last Update: 09/11/2023 08:56 PM
Current Deck: L38 Bone and Joints Path II
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What MSK pathology is characterized histologically by a mosaic pattern of woven and lamellar bone?
{{c1::Paget disease of bone}}
Extra
osteocytes within lacunae in chaotic juxtapositions; "puzzle piece pattern"
Lecture Notes
LN
Osteolytic phase (Osteitis Deformans)
Predominant osteoclastic activity → > 100 nuclei lytic lesions ↑ Bone resorption markers
Mixed Phase Osteoclastic + osteoblastic activity
LCT with osteoprogenitor cells & many blood vessels
New woven bone formation → thin & thick bony trabeculae
Blastic/ Osteosclerotic/ Burnout Phase
Predominant osteoblastic activity Jigsaw/ Mosaic pattern of lamellar bone with coarsely thickened trabeculae & irregular cement lines Lack structural ability → bones prone to fx
Osteolytic phase (Osteitis Deformans)
Predominant osteoclastic activity → > 100 nuclei lytic lesions ↑ Bone resorption markers
Mixed Phase Osteoclastic + osteoblastic activity
LCT with osteoprogenitor cells & many blood vessels
New woven bone formation → thin & thick bony trabeculae
Blastic/ Osteosclerotic/ Burnout Phase
Predominant osteoblastic activity Jigsaw/ Mosaic pattern of lamellar bone with coarsely thickened trabeculae & irregular cement lines Lack structural ability → bones prone to fx
Missed Questions
Pathoma
Boards and Beyond
First Aid
Sketchy
Pixorize
Physeo
OME
Additional Resources
Paget, Remodeling, Mosaic, Hat: Imagine a model with a hat walking down the pageant runway, which is a mosaic.
Atlas:
normal = straight lines, paget = mosaic, cement lines
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