Review Note
Last Update: 11/04/2023 04:50 PM
Current Deck: PHYL 2041 (Exam 2)
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Front
Illustrate how stereocilia deflections lead to membrane depolarization and hyperpolarization of hair cells. Which ion current causes the depolarization (and the subsequent rapid hyperpolarization)? How do graded receptor potentials in hair cells lead to action potentials in primary sensory neurons?
Back
- Stereocilia contain mechanically gated cation channels connected by tip links
- Bending of stereocilia opens or closes cation channels, modifying influx of K+, depolarizing the membrane (endolymph has high K+ conc.)
- Membrane depol. causes opening of VG-Ca2+ channels
- Ca2+ influx triggers release of NT glutamate, causing depol. of sensory neurons
- APs generated in sensory neurons
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