Review Note
Last Update: 10/21/2023 10:11 PM
Current Deck: All Exams P1::Pharm116 Exam#2::Handout 2
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Glycerophosphate Shuttle (brain + skeletal muscle)
- NAD+ needs to be regenerated for glycolysis since {{c1::GAP → 1,3BPG needs NAD+ }}
- Pyruvate not used to regenerate NAD+ because {{c2::it can get across inner membrane of mitochondria to make lots of ATP using oxygen}}
- {{c3::3-phosphoglycerol Dehydrogenase}} enzyme uses {{c4::NADH + DHAP → NAD+ and 3-Phosphoglycerol}}
- {{c5::3-Phosphoglycerol}} is substrate for {{c6::Flavoprotein Dehydrogenase inner mitochondrial membrane enzyme}}
- FAD cofactor {{c7::covalently attached to Flavoprotein Dehydrogenase active site}}
- Hydrogen Atom Transfer to {{c8::FAD from 3-Phosphoglycerol → FADH2 (different from NAD+ → NADH using Hydride Ion Transfer) }} and 3-Phosphoglycerol → DHAP in active site.
- FADH2 forms {{c9::1.5}} ATP using oxygen in ETC
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